Over 200 genes might affect your chances of getting MS. But genes are only part of the story. MS can happen more than once in a family, but it's much more likely this will not happen. There's only about a 1.5% chance of a child developing MS when their mother or father has it (that means around one in 67 get it).
your genes – MS isn't directly inherited, but people who are related to someone with the condition are more likely to develop it; the chance of a sibling or child of someone with MS also developing it is estimated to be around 2 to 3 in 100.
The risk of developing MS also increases when other first-degree relatives (parents, siblings and children) have MS, but far less than in identical twins. Research is ongoing to better understand how genetic risk contributes to the development of MS.
The risk of the brother or sister of someone with MS also developing the condition was about seven times higher than in the general population. Previous studies suggested this risk was about nine times higher.
Race. White people, particularly those of Northern European descent, are at highest risk of developing MS . People of Asian, African or Native American descent have the lowest risk. A recent study suggests that the number of Black and Hispanic young adults with multiple sclerosis may be greater than previously thought.
There's only about a 1.5% chance of a child developing MS when their mother or father has it (that means around one in 67 get it). There's only around a 2.7% chance that you'll get MS if your brother or sister has it (around one in 37 get it).
MS can appear at any age but most commonly manifests between the ages of 20 and 40. It affects women two to three times as often as men. Almost one million people in the United States have MS, making it one of the most common causes of neurological disability among young adults in North America.
Here's where MS (typically) starts
You may experience eye pain, blurred vision and headache. It often occurs on one side and can eventually lead to partial or total vision loss. Spinal cord inflammation, or what's called partial transverse myelitis, is the second most common symptom Shoemaker typically sees.
It's most commonly diagnosed in people in their 20s, 30s and 40s although it can develop at any age. It's about 2 to 3 times more common in women than men. MS is one of the most common causes of disability in younger adults.
Changes in the HLA-DRB1 gene are the strongest genetic risk factors for developing multiple sclerosis.
Stress has been linked to a long list of chronic health conditions, including multiple sclerosis (MS). Though evidence is mixed, some research suggests stress could increase the risk of MS and trigger relapses (also called flare-ups ad exacerbations).
Although more people are being diagnosed with MS today than in the past, the reasons for this are not clear. Likely contributors include greater awareness of the disease, better access to medical care and improved diagnostic capabilities. There is no definitive evidence that the rate of MS is generally on the increase.
"If a mom has MS, her children have a 5 percent risk of having MS, and if a dad does, his daughters also have a 5% risk, but his sons have less of a risk," says Dr. Rose. It's usually a combo of factors—genes and environmental triggers—that result in MS, even within families.
Patients are not born with MS, but rather some environmental factor apparently acts on genetically susceptible individuals to produce the disease; but the nature of that factor (such as whether or not it is a virus) remains elusive.
How long can MS go undiagnosed? MS is usually diagnosed between the ages of 20 and 50, but it can go undetected for years. In fact, a 2021 study suggested that many people with MS experience disease symptoms several years before being officially diagnosed with the disease.
Early MS symptoms may include blurred vision, numbness, dizziness, muscle weakness, and coordination issues. MS is progressive and can worsen over time. Eventually, the disease can do damage directly to the nerves, causing permanent disability.
Blood Tests: Currently, there are no definitive blood tests for diagnosing MS, but they can be used to rule out other conditions that may mimic MS symptoms, including Lyme disease, collagen-vascular diseases, rare hereditary disorders and acquired immune deficiency syndrome (AIDS).
Fatigue in MS is not just an ordinary tiredness, like you might get at the end of a hard day's work. People describe it as an overwhelming sense of tiredness with no obvious cause. You may wake up feeling as tired as you did when you went to sleep.
It is also known as neuromyelitis optica (NMO) or Devic's disease. Some of its symptoms are similar to the symptoms of multiple sclerosis, so it may be misdiagnosed as such.
While MS is not contagious or hereditary, MS susceptibility is increased if a family member has MS. The average risk of developing MS in the United States is roughly 3.5 in 1,000, or less than half of one percent. For first-degree relatives (such as a child or sibling), the risk increases to three or four percent.
How to self-assess multiple sclerosis symptoms. A multiple sclerosis (MS) self-assessment cannot diagnose MS, but it may help a person understand their symptoms and know when to contact a doctor. An MS self-assessment may focus on energy levels, physical sensations, vision problems, and more.