Brucellosis can be treated with antibiotics – but it can take a long time, and treatment can be difficult. Depending on the severity of the illness – and when treatment is begun – it can take anywhere from a few weeks to a few months to recover.
Possible complications include: Inflammation of the inner lining of the heart chambers (endocarditis). This is one of the most serious complications of brucellosis. Untreated endocarditis can damage or destroy the heart valves and is the leading cause of brucellosis-related deaths.
The symptoms usually improve and are completely gone within about two to six months. However, the prognosis is poor in people who develop organ changes or complications such as heart damage, neurological, or genitourinary problems caused by chronic Brucella infection.
Treatment options include doxycycline 100 mg twice a day for 45 days, plus streptomycin 1 g daily for 15 days. The main alternative therapy is doxycycline at 100 mg, twice a day for 45 days, plus rifampicin at 15mg/kg/day (600-900mg) for 45 days.
Brucellosis affects males and females in equal numbers. The disorder is rare in the United States since pasteurization of milk is routine and cattle are vaccinated against this disease. Fewer than 100 new cases are reported each year in the United States.
People with brucellosis may develop fever, sweats, headaches, back pains, and physical weakness. In severe cases, the central nervous system and the lining of the heart may be affected. One form of the illness may also cause long-lasting symptoms, including recurrent fevers, joint pain, and fatigue.
Brucellosis can be diagnosed in a laboratory by finding bacteria in samples of blood, bone marrow or other bodily fluids. Serological tests can also be done to detect antibodies against the bacteria.
Brucellosis is an infectious disease caused by Brucella species. It is known by many other names, including remitting fever, undulant fever, Mediterranean fever, Maltese fever, Gibraltar fever, Crimean fever, goat fever, and Bang disease.
Symptoms and Signs of Brucellosis
Onset may be sudden, with chills and fever, severe headache, joint and low back pain, malaise, and occasionally diarrhea. Or onset may be insidious, with mild prodromal malaise, muscle pain, headache, and pain in the back of the neck, followed by a rise in evening temperature.
Brucellosis is an infectious disease caused by bacteria. People can get the disease when they are in contact with infected animals or animal products contaminated with the bacteria. Animals that are most commonly infected include sheep, cattle, goats, pigs, and dogs, among others.
For simple infections, doxycycline (100 mg PO twice daily for 6 weeks) may be the most appropriate monotherapy; however, relapse rates with such monotherapy approach 40% and as a result, rifampin (600-900 mg/day) is usually added.
Sexual transmission of brucellosis has rarely been reported in humans. We describe 2 cases of probable sexual transmission of Brucella from husband to wife.
Overall, three (9.38%) patients had known risk factors for tuberculosis, while six (18.75%) had risk factors for brucellosis. Conclusions: There is a clear overlap between brucellosis and tuberculosis both in terms of clinical presentation and laboratory parameters.
Although vaccination of individuals living in brucellosis endemic areas, veterinarians, livestock, and laboratory personnel is essential, human vaccines have not yet been developed (9). Live-attenuated vaccines are the most effective vaccines used to control animal brucellosis (10).
Brucellosis in humans is usually associated with consumption of unpasteurized milk and soft cheeses made from the milk of infected animals—primarily goats, infected with B. melitensis and with occupational exposure of laboratory workers, veterinarians, and slaughterhouse workers.
Brucellosis is a reportable condition in all states and territories. Brucellosis cases must be reported to jurisdictions when identified by a healthcare provider, hospital, or laboratory.
An abnormal (positive) result usually means you have come in contact with the bacteria that causes brucellosis. However, this positive result does not mean that you have an active infection. Your provider will have you repeat the test after a few weeks to see if the test result increases.
Doctors usually confirm a diagnosis of brucellosis by testing blood or bone marrow for the brucella bacteria or by testing blood for antibodies to the bacteria. To help detect complications of brucellosis, your doctor may order additional tests, including: X-rays. X-rays can reveal changes in your bones and joints.
Lethality: Brucellosis has a very low mortality rate, less than 5% of untreated cases, with most deaths caused by endocarditis or meningitis.
Person-to-person spread of brucellosis is extremely rare. Infected mothers who are breast-feeding may transmit the infection to their infants. Sexual transmission has been rarely reported. While uncommon, transmission may also occur via tissue transplantation or blood transfusions.
Brucellosis can spread from dogs to people through contact with an infected dog's birthing fluids and vaginal discharge while birthing puppies. This is why dog breeders and veterinarians are at higher risk.
Myth: Antibiotics do not harm the immune system.
Fact: Although antibiotics do not directly interfere with the immune system, unnecessary antibiotic usage can stop the immune system from working to its full potential.
Doxycycline starts working in as little as 2 hours after taking it. But depending on the infection you have, it may take up to 24 to 48 hours (1 to 2 days) to start seeing its effects. It typically takes 1 to 2 weeks for doxycycline to fully clear an infection, but some infections can take as long as 2 months.
Doxycycline belongs to the class of medicines known as tetracycline antibiotics. It works by killing bacteria or preventing their growth. However, this medicine will not work for colds, flu, or other virus infections.