If you mean an omnipotent, omniscient creator, then no, Saitama cannot defeat him.
Saitama is by far the strongest character in the series. From the very first episode, it has been established that no entity can match Saitama's power.
After receiving what seem-to-be a fraction of power from "God", Garou mutated, gained various powerful abilities, and became capable enough to fight against and even force Saitama to get serious before ultimately being defeated.
Saitama takes on God in One-Punch Man: The Fight of Gods, a passion project for one fan artist. In an effort to save the universe, Saitama punches God in the face in the non-canonical One-Punch Man: The Fight of Gods, a fan-made comic based on the popular anime, manga and webcomic.
Goku is an extraterrestrial being who has to lose a fight in order to get stronger. Saitama is a man that can defeat any foe with a single punch. If the two of them were to face off in a one-on-one battle, Saitama would easily win.
Saitama (1000 IQ) VS 1.000. 000 Colossal Titans: 1.000 IQ, 100 IQ, 10 IQ!
Many fans consider Jiren to be stronger than Goku based on the exceptional abilities and feats that he demonstrated in the Tournament of Power arc. He possesses an overwhelming amount of power and strength.
This reference was then overshadowed by the incredibly epic battle between Saitama and Garou, but the manga has now confirmed that, in fact, God is aware of Saitama's existence and is attracted to him for unknown reasons.
The origin of Saitama's immeasurable power remains mysterious and unclear. Although he tells everyone he got his incredible power through mere physical training, no one believes him at all.
God finally appeared to Saitama, the S-Class hero Flashy Flash and the monster Oculette, when they touched a strange, cube-shaped object, and were able to hear God's voice in their heads. He offered them to make a "fervent wish", to see if they were "worthy vessels to bestow my power upon".
God is the overarching antagonist of the Monster Association arc in the manga One Punch Man and possibly the entire series. It is a mysterious entity that desires the eradication of all humanity. However, it chooses to remain hidden for the time being and instead grants powers to others who share its thoughts.
Saitama vs cat
[ Still trying to do the math on how, the only thing to ever actually damage Saitama in the series is a cat scratching his face.
The only event that came close to becoming a God-level Disaster Threat was the meteor in the first season, which Saitama managed to stop easily. Otherwise, for now, it seems like the only God-level threat that the universe might face is from God himself, who has made himself known numerous times in the manga.
The Tournament of Power shows that Zeno can erase an entire universe, so whichever approach he takes against Saitama is still going to end in his end.
Secondly, some people claim that the writer of OPM(One) has said that the limit of Saitama's power is that he can destroy half a universe with one full-powered punch. This isn't true. One has never said anything like that, and it is only a rumor.
Blast is widely known as the S-Class rank 1 hero and the Hero Association's most powerful asset—as Saitama's strength is not yet widely recognized. Full details about his abilities and whereabouts were unknown for most of the series.
According to Saitama, he achieved immense strength by performing 100 push-ups, 100 squats, 100 sit-ups, and running 10 kilometers daily for about a year.
“Nobody knows who he is.” Saitama's lack of a surname makes him fade out into the crowd and makes him forgotten. This is then carried over to the second season where King takes all the credit for Saitama's win without anyone actually knowing it was actually Saitama.
Despite having received God's powers, there wasn't anything Garou could do to defeat the Caped Baldy. Suffice to say, Saitama hasn't lost a single fight in the One Punch Man manga so far.
That is, God's height is approximately 84% of the Moon's diameter. If the Moon in the One Punch Man universe has the same dimension as the Moon in our universe, that is, considering it a perfect sphere 3,474.8 km in diameter, we have that the height of God is approximately 2,921.4 km.
The origin of Saitama's power is beyond human comprehension, leading some to theorize that he could be anything but. One-Punch Man's Saitama is unrivaled, his power absolute. With one punch, Saitama can end the career of a god-tier villain without breaking a sweat.
YES! Saitama is stronger than goku in latest mangga Saitama is limitless! he will never reach his maximum power because he does not have a maximum he is limitless, he will just keep increasing his power infinitely.
Zeus is king of the gods and has the strength, power, and durability to prove it, but the gods introduced in Blood ofZeus pale in comparison to Beerus. Though Goku is still unable to defeat the god of destruction, he would certainly defeat Zeus.
In the early days of Dragon Ball, there existed a being strong enough to beat the God of Destruction Lord Beerus, but Goku accidentally killed him.