Leukaemias are grouped in two ways: the type of white blood cell affected - lymphoid or myeloid; and how quickly the disease develops and gets worse. Acute leukaemia appears suddenly and grows quickly while chronic leukaemia appears gradually and develops slowly over months to years.
Chronic leukemia usually gets worse slowly, over months to years, while acute leukemia develops quickly and progresses over days to weeks. The two main types of leukemia can be further organized into groups that are based on the type of white blood cell that is affected — lymphoid or myeloid.
Acute leukemia symptoms can often appear suddenly
With acute leukemia, symptoms tend to develop very quickly. You may suddenly spike a fever that won't go away, develop an infection for no apparent reason, or start bleeding spontaneously from your nose or gums and not be able to stop it.
Persistent fatigue, weakness. Frequent or severe infections. Losing weight without trying. Swollen lymph nodes, enlarged liver or spleen.
Acute lymphocytic leukemia occurs when a bone marrow cell develops changes (mutations) in its genetic material or DNA. A cell's DNA contains the instructions that tell a cell what to do. Normally, the DNA tells the cell to grow at a set rate and to die at a set time.
Leukemia starts in the soft, inner part of the bones (bone marrow), but often moves quickly into the blood. It can then spread to other parts of the body, such as the lymph nodes, spleen, liver, central nervous system and other organs.
Acute leukemias — which are incredibly rare — are the most rapidly progressing cancer we know of. The white cells in the blood grow very quickly, over a matter of days to weeks. Sometimes a patient with acute leukemia has no symptoms or has normal blood work even a few weeks or months before the diagnosis.
"A patient may be tested for leukemia if he or she has unexplained weight loss, night sweats or fatigue, or if he or she bruises or bleeds easily," Dr. Siddon says. "Sometimes routine blood work shows an unexplained elevated number of white blood cells."
Leukemia is commonly misdiagnosed as the following conditions: Influenza. Fever. Pathological fracture.
Chronic leukemia often causes only a few symptoms or none at all. Signs and symptoms usually develop gradually. People with a chronic leukemia often complain that they just do not feel well. The disease is often found during a routine blood test.
In CLL, the leukemia cells grow out of control and crowd out normal blood cells. These cells often build up slowly over time. Many people don't have any symptoms for at least a few years. In time, the cells can spread to other parts of the body, including the lymph nodes, liver, and spleen.
By looking at a sample of your blood, your doctor can determine if you have abnormal levels of red or white blood cells or platelets — which may suggest leukemia. A blood test may also show the presence of leukemia cells, though not all types of leukemia cause the leukemia cells to circulate in the blood.
Many types of leukemia produce no obvious symptoms in the early stages. Eventually, symptoms may include any of the following: Anemia and related symptoms, such as fatigue, pallor, and a general feeling of illness.
Acute leukaemia develops very quickly. Chronic leukaemia tends to develop slowly. Usually over months or years without causing many symptoms.
Age-specific incidence rates fall gradually from age 0-4 and remain stable throughout childhood and early adulthood, rates rise sharply from around age 55-59. The highest rates are in in the 85 to 89 age group for females and males. Incidence rates are significantly lower in females than males in most age groups.
Leukemia occurs when one type of immature blood cell mutates and begins growing uncontrollably. The overgrowth of one type of blood cell crowds out the others, causing a range of symptoms. Leukemia can develop at any age.
Some symptoms, like night sweats, fever, fatigue and achiness, resemble flu-like symptoms. Unlike symptoms of the flu, which generally subside as you get better, leukemia symptoms generally last longer than two weeks, and may include sudden weight loss, bone and joint pain and easy bleeding or bruising.
Myelodysplastic syndrome (MDS) used to be known as “pre-leukemia,” or sometimes “smoldering leukemia.” MDS is a group of blood disorders that can cause you to have low levels of: red blood cells. white blood cells. platelets.
If caught early, leukemia can be cured by undergoing several cancer treatments.
If you have leukemia, your blood cells count will likely show higher than usual levels of white blood cells, which include leukemic cells. You may also have lower than usual red blood cell and platelet cell counts. If all three types are low, this is known as pancytopenia.
Bone pain can occur in leukemia patients when the bone marrow expands from the accumulation of abnormal white blood cells and may manifest as a sharp pain or a dull pain, depending on the location. The long bones of the legs and arms are the most common location to experience this pain.
While the exact cause of leukemia—or any cancer, for that matter—is unknown, there are several risk factors that have been identified, such as radiation exposure, previous cancer treatment and being over the age of 65.
If a person appears pale, has enlarged lymph nodes, swollen gums, an enlarged liver or spleen, significant bruising, bleeding, fever, persistent infections, fatigue, or a small pinpoint rash, the doctor should suspect leukemia. A blood test showing an abnormal white cell count may suggest the diagnosis.