After five to 10 years, low-grade disorders begin to progress rapidly to become aggressive or high-grade and produce more severe symptoms. This type progresses fairly rapidly without treatment.
Non-Hodgkin lymphoma grows and spreads at different rates and can be indolent or aggressive. Indolent lymphoma tends to grow and spread slowly, and has few signs and symptoms. Aggressive lymphoma grows and spreads quickly, and has signs and symptoms that can be severe.
Burkitt lymphoma grows very rapidly, which means that symptoms usually develop quickly, over just a few days or weeks. The most common symptom is one or more lumps, which often develop in several parts of your body.
With lymphoma, the lymph nodes often grow slowly and may be there for months or years before they're noticed. But sometimes they grow very quickly. Usually, the swollen nodes don't hurt.
Burkitt lymphoma is considered the most aggressive form of lymphoma and is one of the fastest growing of all cancers.
you develop 'B symptoms' (night sweats, weight loss and fevers) your lymph nodes or spleen start to grow quickly or you develop swollen lymph nodes in new places. your blood tests or other test results show that lymphoma is affecting your major organs or is growing in your bone marrow.
In a few people, lymphoma might transform within months of diagnosis. In others, lymphoma might transform many years later. Some research suggests that the risk of lymphoma transforming becomes lower around 15 to 20 years after diagnosis. Your medical team check for signs of transformation at all your appointments.
Signs and Symptoms
NHL is a disease that usually comes on suddenly and gets worse quickly. Symptoms vary depending on where tumor(s) are. These are the most common locations and their symptoms: Abdomen – pain, swelling, fever, anemia, tiredness, weight loss, vomiting, diarrhea, constipation, and irregular periods.
If you have an aggressive (fast-growing) lymphoma, you will likely notice your symptoms as they develop over a short period of time, such as days to weeks. Because lymphoma can grow in any part of your body, there are many different symptoms you may experience.
You should have an urgent referral if you have swollen lymph nodes and your GP can't explain the cause. Your GP will also take into account any other symptoms you might have such as: high temperatures (fevers) night sweats.
Stage III-IV: There is cancer in lymph node areas on both sides of the diaphragm (stage III), or the cancer has spread throughout the body beyond the lymph nodes (stage IV). Lymphoma most often spreads to the liver, bone marrow, or lungs.
Lymph nodes can swell for a variety of reasons and are considered to be enlarged if they are bigger than 1.5 centimeters in diameter, or slightly larger than a pea. Typically, lymph nodes that are enlarged due to lymphoma are much bigger and can grow to be the size of a grape (or larger).
Hodgkin lymphoma is a relatively aggressive cancer and can quickly spread through the body. Despite this, it's also one of the most easily treated types of cancer. Your recommended treatment plan will depend on your general health and age, because many of the treatments can put a tremendous strain on the body.
For stage I NHL, the 5-year relative survival rate is more than 86%. For stage II the 5-year relative survival rate is 78%, and for stage III it is more than 72%. For stage IV NHL, the 5-year relative survival rate is almost 64%.
A lymphoma lump also tends to be movable under the skin versus hard and unmovable. Lumps can appear in multiple locations on the body at once and in groups. These can show up throughout several years or can occur within just a few days.
Cancer-related fatigue is exhaustion that's at a much higher level than would usually be expected – you might feel tired very quickly after doing quite little. It can be physical, emotional or mental exhaustion.
Lymphoma is cancer that starts in the lymph nodes. For example, if breast cancer spreads to the lymph nodes in the armpits it does not become lymphoma. The cancer cells that have spread to the lymph nodes are still breast cancer cells.
Stage 1 lymphoma – Cancer is found in one lymph node, a lymphoid organ such as the thymus or one area of a single organ outside of the lymphatic system. Stage 2 lymphoma – Cancer is found in two lymph nodes (both on the same side of the diaphragm) or extends from one lymph node into a nearby organ.
NHL is a serious condition but commonly has a relatively promising outlook. Most people with NHL survive at least 5 years after a diagnosis. However, older people are more likely to die from the condition. Other factors that affect the outlook include the stage and spread of the cancer.
Blood Tests for Lymphoma
Blood tests are essential to accurately diagnosing this complex disease. These tests can show whether you have lymphoma cells or abnormal levels of normal cells: Blood smear: We take a drop of blood and look at it under a microscope.
Common symptoms of having lymphoma include swelling of lymph nodes in your neck, in your armpits or your groin. This is often but not always painless and often could be associated with fevers, or unexplained weight loss, or drenching night sweats, sometimes chills, persistent fatigue.
feeling uncomfortably full or feeling sick caused by a swelling in your stomach area. itching either widespread or in one place. bone pain if the lymphoma affects the bone marrow inside your bones. skin rashes or lumps.
Because follicular lymphoma typically grows slowly and might not cause any symptoms, it is often advanced (stage 3 or 4) by the time it is diagnosed. There are treatments for all stages of follicular lymphoma, which can usually keep the lymphoma under control for many years.