Just like the Hulk,
The only character to have stopped Juggernaut while he was in motion as an act of pure physical strength was the Hulk while he was War, a horseman of Apocalypse and empowered with Celestial technology. When Marko gains complete access to the Gem's powers during the Trion saga, it increases his power a thousandfold.
Thanks to his magical powers, Juggernaut is capable of creating powerful forcefields. In this case, he was able to slow down Thor's hammer. If that wasn't enough, Juggernaut grabs onto Mjolnir as it returns to Thor and launches himself directly into the Avenger.
In their normal states, Juggernaut and Thor are pretty evenly matched in terms of brute strength. However, Juggernaut has a definitive advantage with his virtually unlimited stamina. As mighty as Thor is, battling Juggernaut would surely be taxing, so he wouldn't be able to fend Cain off indefinitely.
In reality, Juggernaut is virtually unstoppable without magic, but the Hulk is stronger than Juggernaut. So, it makes for an exciting fight. And while it is always going to be a close battle, Hulk beats Juggernaut.
Juggernaut Barely Defeated the Hulk
The Immortal Hulk was able to effortlessly throw around Juggernaut like a ragdoll.
Other than Thor and Odin, certain other individuals have proven worthy of lifting Mjolnir in the primary continuity: Roger "Red" Norvell (a deliberate ruse by Odin) Beta Ray Bill. Buri (also known as Tiwaz, Thor's great-grandfather)
Hela Was Worthy Enough to Destroy Mjolnir
Many people other than Thor have wielded Mjolnir, including his sister Hela. But the impactful scene in Thor: Ragnarok depicts Hela catching Mjolnir in mid-air before then crushing it to pieces. Odin previously told Thor the power of the Uru metal had no equal.
Forged by dwarves in the heart of a dying star, the weapon is enchanted so that it can only be lifted and wielded by those who are worthy of its powers. Both in the comics and the MCU films, many characters other than Thor himself, both heroes and villains, have been able to lift Mjolnir.
Juggernaut is one of Marvel's toughest characters, but everyone has a weakness. Achilles had his heel, while Juggernaut has...bees? Warning! Spoilers ahead for Juggernaut #5. Cain Marko may be known as the unstoppable Juggernaut, but the name isn't exactly accurate.
Cain Marko, AKA Juggernaut
As a child, Cain was abused by his father and, in turn, bullied Xavier. During that period, Charles accidentally read Cain's mind following an incident of abuse. The former came to hate the latter for using his powers on him, and their relationship is often tense.
While Juggernaut cannot be harmed by any physical weapon, he can be harmed by mystical weapons from beings of immense power. Once he is injured by the attack, the gem immediately heals his wounds.
While it is true that the hammer would have been an incredible asset for the player, it cannot be wielded or even picked up by Kratos (nor Atreus) for several reasons.
All the heroes try to take him down, but at the end of it all, it all comes down to the most unlikely of heroes going up against the King In Black: Eddie Brock, Venom. And just to give himself that extra leg up, he grabs Mjolnir from Thor and uses it to clobber Knull.
Why is this such a big deal? Well, for starters, the hammer in question, Mjolnir, can only be wielded by those who are considered “worthy,” a little mystical insurance policy put on it by Thor's dad, Odin. It's pretty cool to see the Avenger who is the purest of heart officially deemed “worthy” of the weapon of a god.
And Mathaudhu can cite documentary sources to back him up. For example, Marvel – which publishes the Thor comics – issued a “Thor's Hammer” trading card in 1991 that states Mjolnir is made of Uru and weighs precisely 42.3 pounds. That's lighter than a herd of 300 billion mice, much less a herd of 300 billion elephants.
Mjolnir is a hammer, and was enchanted by Thor's father, Odin, so that only those the hammer deemed "worthy" are capable of wielding or even lifting it. Stormbreaker is an axe, and although it does not have such a worthiness enchantment, its power is such that a mere mortal attempting to wield it would be driven mad.
Interestingly, according to comics, one of Moon Knight's abilities even allows him to control Thor's hammer (Mjolnir) which otherwise only Captain America and Hela could do in previous MCU films.
Thor has been defined by his weapon and whether or not he can lift it. While losing Mjolnir undoubtedly makes Thor a weaker fighter, but a much stronger character; now, the question of worthiness is up to him, and he cannot rely on a weapon to tell him if he's doing the right thing.
Thanos didn't lift Mjolnir, Captain America did
With Mjolnir's worthiness enchantment resulted in Thor being able to lift the hammer only if he is considered to be worthy, but likewise, the enchantment is not discriminatory in nature, and anyone who is deemed worthy is able to lift the hammer.
It's also notable that Hulk has only ever been shown to lift Mjolnir through brute force, and it's highly unlikely the hulking beast will ever be considered truly worthy.
So while Juggernaut is much more powerful, and would normally be able to win in a fight, Colossus could convince Cyttorak to transfer his power, or even cut off Cain Marko's connection to Cyttorak. Cain Marko would be left as a normal human. Colossus would still be a powerful mutant.
A character that can transmute practically anything into nearly anything else, Firestorm could beat Juggernaut by effectively taking away his ability to build momentum — an important element to Cain's unstoppable and highly destructive wrath.
Before he can defeat him, the Immortal Hulk is stopped by the Savage Hulk, who is being emotionally manipulated by the Leader. The Immortal Hulk is beheaded by a monstrous Leader and his heart is ripped out. His corpse, alongside Banner, is taken to the Below-Place by the Leader.
And the comic claim that Mjölnir is made out of Uru, a metal that only comes from Asgard. Make-believe metal is kind of hard to weigh. But then, in 1991, Marvel released a "Thor's Hammer" trading card that claims that Mjolnir weighs precisely 42.3 pounds.