Sanemi's sheer power and speed will be able to overwhelm Nezuko even in her final form. Nezuko's Blood Demon Art would not work against Sanemi since he's a human, and he has the ability to decapitate her head if he wanted to.
Unfortunately, even if Nezuko were to fight back against Sanemi's cruelty, she'd probably find herself outmatched. Much like Giyu, Sanemi has encountered and defeated far stronger demons than Nezuko to make his way to the top of the Demon Slayer Corp.
Sanemi also has great enough control over his muscles to manipulate them into forcing wounds closed and such, a great feat indeed. Finally, his strength and skills are said by Kokushibo to be at their absolute peak, further solidifying Tanjiro's hopeless chances against Sanemi in a fight.
She was ranked in 3rd place in the first Demon Slayer character popularity poll with 3,319 votes. IGN regarded Nezuko as one of the series's most popular characters and noted how her design elaborates the way she sees humans as good people as a result of hypnosis.
Gyomei's raw power and his long-range weapon would be more than enough to keep Nezuko at bay, and he could defeat her without struggling too much.
4) Kokushibo
The Upper Moon 1 is a swordsman and is capable of causing a ton of destruction from any range. Nezuko will have to give her all to just keep up with someone like him. Kokushibo would easily be able to defeat her in a 1v1 combat.
Nezuko is easily one of the most powerful demons in the Demon Slayer series, possibly due to the large quantity of blood she was given by Muzan. But what makes her a truly terrifying opponent is her willpower, being the only other demon after Tamayo to escape Muzan's control.
Nezuko Kamado is one of the youngest characters in Demon Slayer as she is only 12 years old at the start of the story when she is turned into a demon.
Nezuko is physically 12, and chronologically 14 since she became a demon in age of 12, and it already past 2 years after that time.
Nezuko's inability to speak is one of her character defining traits. However, one theory suggests a deeper meaning behind the silence. Nezuko is one of Demon Slayer's most popular characters, adored by fans for her cuteness. However, despite being so renowned, Nezuko rarely ever speaks.
It affects even the strongest of the Upper Rank demons. This would be effective against Akaza because the only people he refuses to eat are women, since that goes against his morals. Sanemi also has excellent control of his muscles, saving himself from fatal injuries by closing them up himself.
Despite his performance against the Upper Moon 6 and Muzan, Sanemi would easily defeat Inosuke due to his superior strength and speed. To add to this, the latter has also accrued way more battle experience which would certainly aid in a face-off against Inosuke.
3) Sanemi Shinazugawa
After awakening his demon slayer mark, his agility and strength increased, and in conjunction with Gyomei, he decapitated the demon eventually. Doma would be a tough opponent of Sanemi however, with his ridiculous speed, he can turn the tides in a fight against him.
Which Hashira can beat Nezuko? The Wind Hashira is one of the strongest Hashiras in the Demon Slayer series. He played a significant role in defeating Kokushibo and was able to inflict damage on Muzan. Sanemi's sheer power and speed will be able to overwhelm Nezuko even in her final form.
1/10 Muzan (Demon Slayer)
Without that antidote, it would have been impossible to kill him. So despite all her strength and humanity, Nezuko would have easily lost to Muzan.
Physical ability
Nezuko would be far stronger than Tanjiro in the base form in terms of pure physical abilities. But Tanjiro gained superhuman strength and speed owing to the activation of the Demon Slayer Mark. Comparing the two in these forms, Nezuko might still outperform in terms of speed and strength.
Nezuko survives without eating humans because unlike other demons who need human flesh to get back their energy , nezuko gets back her energy sleeping . As we see in the anime she sleeps in the box Tanjiro carries on his back .
Zenitsu Agatsuma
Upon seeing her for the first time, Zenitsu falls in love with Nezuko at first sight. She apparently views Zenitsu as a "weird dandelion" and did not initially seem to reciprocate his feelings. Although the two are rarely seen interacting together, Zenitsu treats her with affection and care.
The now-iconic bamboo muzzle serves as a way of stopping Nezuko from using her teeth, and also keeps her from tasting human blood, which would cause her to lose control of herself.
Akaza's appearance as a human at the age of 18.
For someone only 21 years of age, Sanemi has a lot of pent-up anger, but his hatred for demons is justified. Despite his age, one could mistake Sanemi for a teenager with too foul of a mouth and too short a temper.
As for the "first ever Hashira"...that is unknown. As for the "last ever Hashira"...that would be Shinazugawa-san as well as Tomioka-san.
However, she wasn't immune to the sunlight initially, as she got burned badly at first. So, in conclusion, her coming from a Sun Breathing user's lineage and not relying on human substance are perhaps the reasons for her immunity.
Apart from Tanjiro, the show centers on his younger sister Nezuko Kamado, turned into a demon by Muzan Kibutsuji. Demons are incapable of walking out in broad daylight because the sunlight will burn them into the ashes. However, Nezuko has immunity against the sun, so she was given the name “The Chosen Demon”.
Another way sakura wins is that she literally beats her up so hard that nezuko begins to flee since demons also have a sense of fear (a lot of demons fear hashira) just because there's no way sakura can kill her doesn't mean there's no way sakura can defeat her. Sakura wins from a K.O or nezuko flees.