Having abnormal levels of either dopamine or serotonin can lead to several different medical conditions. Both neurotransmitters can affect mood disorders, such as depression. Imbalances can also result in distinct conditions that affect different bodily functions.
Having too much dopamine — or too much dopamine concentrated in some parts of the brain and not enough in other parts — is linked to being more competitive, aggressive and having poor impulse control. It can lead to conditions that include ADHD, binge eating, addiction and gambling.
High dopamine symptoms include anxiety, excessive energy, insomnia, and hallucinations. Low dopamine levels are associated with brain fog, mood swings, and muscle spasms. This article discusses dopamine and dopamine-related disorders.
The symptoms of depression, whether related to serotonin or dopamine, are very similar. But there are a few distinctions. Dopamine-related depression is characterized by lethargy and apathy, while serotonin-related depression is usually accompanied by feelings of anxiety.
There's evidence that an excess of dopamine can cause vitamin B6 deficiency. This makes sense when you consider that vitamin B6 is a cofactor required for the synthesis of dopamine. So if you feel that you have a high level of dopamine, consider vitamin B6 supplementation.
You can test for low dopamine levels by taking a Dopamine Blood Test. This test measures the dopamine level in your body responsible for some brain functions such as movement, memory, behavior and cognition, pleasurable reward, attention, sleep, mood, and learning.
What hormones cause depression? A drop in estrogen and progesterone may trigger depressive episodes. Increased levels of progesterone, such as through taking a progesterone-only contraceptive, may also increase the risk of depression in some people. Low testosterone levels may also cause depression.
There's no single cause of depression. It can occur for a variety of reasons and it has many different triggers. For some people, an upsetting or stressful life event, such as bereavement, divorce, illness, redundancy and job or money worries, can be the cause. Different causes can often combine to trigger depression.
Dopamine deficiencies are associated with multiple physical and mental disorders, including symptoms of reactive depression and clinical depression.
Some inherited genetic disorders may affect the body's ability to make or metabolize serotonin. Lifestyle and other factors that may also play a role include: Hormonal shifts, such as due to beginning or stopping hormone replacement therapy, menopause, pregnancy, or advancing age. Lack of sunlight.
The most common theory about the cause of schizophrenia is that there are too many dopamine receptors in certain parts of the brain, specifically the mesolimbic pathway. 1 This causes an increase in mesolimbic activity which results in delusions, hallucinations, and other psychotic symptoms.
People with ADHD have at least one defective gene, the DRD2 gene that makes it difficult for neurons to respond to dopamine, the neurotransmitter that is involved in feelings of pleasure and the regulation of attention.
High levels of dopamine caused by drinking, drugs, gambling, playing video games, or using social media can trigger dopamine's excitatory effects. This “excitement” motivates us to continue the activity, which can eventually lead to addiction.
Given that dopamine is a neuromodulator that has been shown to have a variable effect on cognition (i.e., too low or too high levels of dopamine do not improve cognitive functioning), it is likely that it has a similar effect on fatigue. That is, fatigue might result from too much or too little dopamine in the brain.
Research suggests that depression doesn't spring from simply having too much or too little of certain brain chemicals. Rather, there are many possible causes of depression, including faulty mood regulation by the brain, genetic vulnerability, and stressful life events.
The study, which gathered evidence from 361 peer-reviewed scientific studies, found no link between depression and serotonin levels in the blood.
Dopamine: Often called the "happy hormone," dopamine results in feelings of well-being.
Oxytocin modulates anxiety, aggression, and the stress/fear response when one is introduced to different types of stimuli. Anxiety and emotional responsiveness to stress may decrease during periods of high oxytocin activity in the body, such as lactation and sexual activity.
Endorphins – the happiness hormones – that are associated with feeling enchantment. Dopamine, which is produced when we feel satisfied, resulting in feeling happy, excited and stimulated. Oxytocin, which is linked to relationships and helps us to build bonds with other human beings.
Hand tremors or other tremors at rest, loss of balance or coordination, increased muscle/limb stiffness, muscle cramps (symptoms of Parkinson's disease). Restless legs syndrome. Problems with short-term memory, managing daily tasks and solving simple thinking problems (symptoms of cognitive changes).
A number of factors may be responsible for reduced dopamine in the body. These include sleep deprivation, obesity, drug abuse, saturated fat, and stress. Here's a closer look at each.