Hypercalcemia can cause acute pancreatitis, which is the term for inflammation of the pancreas. A 2017 review found that 2 of 19 people with vitamin D toxicity experienced acute pancreatitis as a complication.
It is widely thought that vitamin D plays an important role in the modulation of the inflammation system by regulating the production of inflammatory cytokines and immune cells, which are crucial for the pathogenesis of many immune-related diseases.
The main consequence of vitamin D toxicity is a buildup of calcium in your blood (hypercalcemia), which can cause nausea and vomiting, weakness, and frequent urination. Vitamin D toxicity might progress to bone pain and kidney problems, such as the formation of calcium stones.
Do you know that one of the most vital nutrients that promote bone health is Vitamin D? Yes, multiple studies show that a deficiency of this vitamin can lead to joint pain and swelling.
If you take too much supplemental or prescription vitamin D, it can lead to vitamin D toxicity. The main complication of this is moderate to severe hypercalcemia, which can cause symptoms like vomiting, increased thirst and frequent urination.
What's more, taking too much vitamin D can also negatively impact our health as well as our joint pain because our body simply can't cope! If toxic levels of vitamin D build up in the body it can interfere with your body's absorption of calcium.
If you have too much vitamin D in your blood, it will cause extra calcium absorption. This, in turn, can lead to symptoms like muscle pain, mood disorders, abdominal pain, frequent urination and kidney stones.
Dr Sarah Schenker, a dietitian and author of the British Dietetic Association's food fact-sheet on arthritis, says: “Vitamin D seems to have a role in reducing inflammation and keeping the immune system healthy, making it an important nutrient for different types of arthritis.”
Vitamin D deficiency can cause muscle aches, weakness, and bone pain in people of all ages. Muscle spasms (tetany) may be the first sign of rickets in infants. They are caused by a low calcium level.
One study showed that patients with knee osteoarthritis had low blood levels of vitamin D. Another study found that women who had the high levels of vitamin D were 30 percent less likely to develop rheumatoid arthritis than women with low levels.
There is no simple answer as to the amount of time it takes vitamin D to leave the body. However, with the knowledge that calcidiol provides the best indication of vitamin D levels, it can be asserted that in a time period of 15 days, your body will deplete half of its supply of serum vitamin D.
Therefore, conditions that affect the gut and digestion, like celiac disease, chronic pancreatitis, Crohn's disease, and cystic fibrosis, can reduce vitamin D absorption.
1. Omega-3 fatty acids. Omega-3 fatty acids , which are abundant in fatty fish such as salmon or tuna, are among the most potent anti-inflammatory supplements. These supplements may help fight several types of inflammation, including vascular inflammation.
Vitamin D3 Itself Creates Profound Anti-Inflammatory Effects.
Vitamin D has a key role in modulating immune function with important consequences on health maintenance and disease occurrence, particularly autoimmune disorders. Low serum levels of 25(OH)D have been associated with increased risk of autoimmune disease onset and/or high disease activity.
Fatigue. Bone pain. Muscle weakness, muscle aches or muscle cramps. Mood changes, like depression.
Very high levels of vitamin D can damage the kidneys. It also raises the level of calcium in your blood. High levels of blood calcium (hypercalcemia) can cause confusion, kidney failure, and irregular heartbeat (arrhythmia). Most cases of vitamin D toxicity happen when someone overuses vitamin D supplements.
Following the absorption from the intestines or/and the synthesis by skin, Vitamin D is transferred to the liver where it is metabolically converted into 25(OH)D in the liver, 25 (OH)D has a further metabolic conversion in the kidney.
Glucosamine and chondroitin are two of the most commonly used supplements for arthritis. They're components of cartilage—the substance that cushions the joints. Research on these supplements has been mixed, in part because studies have used varying designs and supplement types.
When vitamin D levels are low and the body isn't able to properly absorb calcium and phosphorus, there is an increased risk of bone pain, bone fractures, muscle pain and muscle weakness.
Scientists have discovered that we wake up stiff and achy because our body's natural ibuprofen has not kicked in yet. As day darkens into night, the circadian clocks in joint tissue suppress inflammation and also the body's production of anti-inflammatory proteins, our natural pain-dampeners.
Too much iron can cause symptoms like fatigue, joint pain and depression. An excess of calcium supplements may cause kidney stones and may increase the risk of prostate cancer and heart disease. And there are other risks, too.
Serious side effects of Vitamin D3
Signs of an allergic reaction, like rash; hives; itching; red, swollen, blistered, or peeling skin with or without fever; wheezing; tightness in the chest or throat; trouble breathing, swallowing, or talking; unusual hoarseness; or swelling of the mouth, face, lips, tongue, or throat.