Macrocytosis associated with vitamin B12 deficiency is also associated with fatal and non-fatal coronary disease, myocardial infarction, stroke, and other circulatory health problems.
Other side effects of vitamin B12 injections are more serious. Early on in treatment, these injections can cause pulmonary embolism (a blood clot that travels to one of your lungs from somewhere else in your body and blocks blood flow in the affected lung) and congestive heart failure.
Symptoms of Vitamin B12 Deficiency
A mild deficiency may cause no symptoms. But if untreated, it may lead to symptoms such as: Weakness, tiredness, or lightheadedness. Heart palpitations and shortness of breath.
Vitamin B12 is involved in the breakdown of a protein called homocysteine. High homocysteine levels are associated with an increased risk of heart disease and stroke as it may promote the formation of blood clots and excess free radical cells, and may impair normal blood vessel function.
Safety and side effects
Your body absorbs only as much as it needs, and any excess passes through your urine. High doses of vitamin B-12, such as those used to treat a deficiency, might cause: Headache. Nausea and vomiting.
If you have any of the following health problems, consult your doctor or pharmacist before using this medication: a certain eye disease (Leber's optic neuropathy), a certain blood disorder (polycythemia vera), gout, iron or folic acid deficiency anemia, low potassium blood levels (hypokalemia).
High. An abnormally high vitamin B-12 status is anything over 900 pg/mL. This result may suggest liver or kidney problems, diabetes, or certain forms of leukemia.
B12 (also known as cobalamin) is essential for keeping your brain and nerves healthy and for making DNA and red blood cells. B12 also helps lower levels of homocysteine, an amino acid linked (in high levels) to dementia, heart disease, stroke, and osteoporosis.
Vitamin B12 has a major influence on the function of neurons and also on the ability of the bone marrow to make red blood cells. B12 Causes Psychiatric Symptoms: B12 deficiency can cause almost any psychiatric symptom, from anxiety, and panic to depression and hallucinations.
But one thing that is clear is that severe vitamin B12 deficiency can cause neuropsychiatric symptoms—including anxiety.
Foods high in vitamin B12
Vitamin B12 deficiency can cause anemia which is one of the most common causes of low blood pressure. Adding more vitamin B 12 can help you fight several health issues as well as low blood pressure.
Vitamins B6, B9, and B12 May Lower Risk of Heart Disease and Stroke. Medical experts at Mt. Sinai say that B6, along with B12 and B9, may boost heart health. B vitamins help your body produce new red blood cells that deliver oxygen to your tissues and organs, benefiting your circulation.
Specifically, we have demonstrated that low vitamin B12 (a) is associated and independently predicted higher total cholesterol, LDL cholesterol, and cholesterol-to-HDL ratio in serum; (b) induced cholesterol biosynthesis and homocysteine in adipocytes; (c) increased expression of SREBPs and genes responsible for ...
Healthcare professionals have not identified an upper limit blood level of vitamin B-12. The body will typically excrete excess vitamin B-12 that a person gets from the diet or via supplements. The body does not absorb vitamin B-12 supplements very effectively.
What Abnormal Results Mean. Values of less than 160 pg/mL (118 pmol/L) are a possible sign of a vitamin B12 deficiency. People with this deficiency are likely to have or develop symptoms. Older adults with a vitamin B12 level less than 100 pg/mL (74 pmol/L) may also have symptoms.
A serum B12 above 300 pg/mL is interpreted as normal. Patients with B12 levels between 200 and 300 pg/mL are considered borderline, and further enzymatic testing may be helpful in diagnosis. Patients with B12 levels below 200 pg/mL are considered deficient.
Vitamin B12 is an essential vitamin that you can get from your diet. When needed, you can also take it as a dietary supplement or prescription medication. Vitamin B12 is a water-soluble vitamin, and the risks of dose-related side effects are low. Your body can usually get rid of excess vitamin B12 through your urine.
Vitamin B-12 is a water-soluble vitamin that plays an important role in the health of older adults. Vitamin B-12 is involved in making DNA, red blood cell formation, and proper nerve function1. While more research is needed, low vitamin B-12 levels have also been linked to increased bone fracture risk2.
Alcohol. Research has suggested that the consumption of alcohol may reduce vitamin B12 levels. An older study indicated that moderate alcohol intake diminished vitamin B12 by 5% among “healthy, well-nourished, postmenopausal women.”
Some combinations should be avoided, even if they aren't inherently problematic. For example, although it's safe to take vitamin D with vitamin B12, it's not advisable, says Virgilio Sanchez, MD, a board certified family medicine physician at Conviva Care Center in Miami, Florida.
Yes, taking vitamin B12 supplements can make you fall asleep and stay asleep due to the production of melatonin. Melatonin is responsible for inducing sleep as it works on the pineal gland.
Around 50% to 98% of vitamin B12 is excreted from the body 48 hours after injection. Research shows that vitamin B12 has a half-life of 6 days in the blood, making it six days before the administered amount gets excreted from your body.