Can you have Huntington's without a parent having it?

An affected person usually inherits the altered gene from one affected parent. In rare cases, an individual with Huntington disease does not have a parent with the disorder. As the altered HTT gene is passed from one generation to the next, the size of the CAG trinucleotide repeat often increases in size.

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Can I get Huntington's disease if my parents don't have it?

Huntington's disease is caused by a faulty gene that results in parts of the brain becoming gradually damaged over time. You're usually only at risk of developing it if one of your parents has or had it. Both men and women can get it.

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Who is most likely to inherit Huntington's disease?

Each child of a parent with HD has a 50 percent chance of inheriting the HD gene. A child who does not inherit the HD gene will not develop the disease, and generally, they cannot pass it on to their children or other future generations.

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Can anyone develop Huntington's disease?

Huntington's disease is a progressive brain disorder caused by a single defective gene on chromosome 4 — one of the 23 human chromosomes that carry a person's entire genetic code. This defect is "dominant," meaning that anyone who inherits it from a parent with Huntington's will eventually develop the disease.

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Do both parents have to carry the gene for Huntington's disease?

Some facts about genetics and Huntington's

Every child conceived naturally to a parent who has the faulty gene has a 50 % chance of inheriting it and the disease. If both parents have the faulty gene the child has a 75 % chance of inheriting it.

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Parents face choice of having children with Huntington's Disease

25 related questions found

Will I get Huntington's disease if my father has it?

Huntington's disease is autosomal dominant, meaning inheritance of just a single copy of an abnormal chromosome from a biological parent is enough to cause it. If one parent carries the abnormal gene, each of their biological children has a 50 percent chance of Huntington's disease inheritance.

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What age does Huntington's disease start?

The symptoms usually start at 30 to 50 years of age, but can begin earlier than this (juvenile Huntington's disease) or much later. Once they start, the symptoms usually get gradually worse.

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What are 4 main symptoms of Huntington's disease?

Signs and symptoms may include:
  • Feelings of irritability, sadness or apathy.
  • Social withdrawal.
  • Insomnia.
  • Fatigue and loss of energy.
  • Frequent thoughts of death, dying or suicide.

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Can you have Huntington's and not know?

Lots of people at risk of Huntington's disease decide they'd rather not know until any symptoms appear. If you do want to know, ask your GP for a referral to a genetic counsellor. You'll have several appointments with the counsellor.

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What is the early stage of Huntington's disease?

In early stage HD, individuals are largely functional and may continue to work, drive, handle money, and live independently. Symptoms may include minor involuntary movements, subtle loss of coordination, difficulty thinking through complex problems, and perhaps some depression, irritability, or disinhibition.

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How fast does Huntington's disease progress?

Huntington's disease (HD) is an autosomal dominant neurodegenerative disorder that usually starts in mid-adult life. The clinical disease progresses to death over an average of 20 years.

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What celebrities have Huntington's disease?

Famous People with Huntington's Disease
  • Woody Guthrie. Woodrow Wilson Guthrie (July 14, 1912– October 3, 1967) was an American musician and songwriter whose legacy involves hundreds of children's songs, traditional songs, ballads as well as improvised works. ...
  • Charles Sabine.

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What gender is Huntington's disease most common in?

In the United States, Huntington's disease occurs in about one of every 10,000 to 20,000 people. It affects males and females equally and crosses all ethnic and racial boundaries. Typically, symptoms begin between age 30 and 55.

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Does Huntington's disease show on MRI?

On neuroimaging atrophy of the corpus striatum involving the caudate and putamen is seen. This change generally proceeds from medial to lateral and dorsal to ventral. These changes are better appreciated on MRI than on CT.

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What are the symptoms of late stage Huntington's disease?

Noticeable changes in personality. Involuntary movements (chorea) and unsteady gait. Slurred speech. Difficulty swallowing and significant weight loss.

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What triggers Huntington disease?

Huntington's disease is caused by a faulty gene. Cells in parts of the brain are very sensitive to the effects of the faulty gene. This makes them function poorly and eventually die. A parent with the Huntington's disease gene has one good copy of the gene and one faulty copy.

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Is motor neurone disease similar to Huntington's?

While ALS, Huntington's disease, and SMA can have very different prognoses, they share a similar method of attack against the body – they all cause the deterioration and death of motor neurons.

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What is the difference between Huntington's and MS?

chronic, progressive, neurodegenerative diseases of the central nervous system. HD is a genetic disorder caused by expanded CAG trinucleotide repeats in the huntingtin (HTT) gene [1]. Conversely, the cause of MS is unknown, and possibly a result of an environ- mental trigger in a genetically susceptible host [2].

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Can you find out if you have Huntington's disease before symptoms occur?

For individuals who are at risk of carrying the HD gene, testing can be performed before symptoms occur. Information from brain scans such as computed tomography (CT), electroencephalography (EEG) and magnetic resonance imaging (MRI) may be reviewed as part of the diagnosis.

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How do people with Huntington's disease behave?

Huntington's disease impairs the functioning of the brain, which can result in apathy, trouble organizing, impulsivity, irritability and anger, unawareness, disinhibition, preservation, and other psychiatric symptoms. These emotional and behavioral symptoms can further complicate the caregiver's role.

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What are the symptoms of Huntington's disease in the eye?

Eye symptoms associated with Huntington's disease include ocular motility problems, like different characteristics of saccades, pursuit and fixation abnormalities, as well as retinal thinning.

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Is Huntington's disease Painful?

The most painful conditions in Huntington's, said Achterberg, are limb pain, headache, abdominal pain and fractures. “I think we should do more work in validation of pain tools, including observational pain instruments,” he said. “And for clinicians, I suggest you be especially aware of abdominal pain.”

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Which parent carries the gene for Huntington's disease?

There have been reports that juvenile onset Huntington's chorea is almost always inherited from the father, and that late-onset Huntington's chorea is inherited more often from the mother than from the father.

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