In the brain, they inhibit activity in the memory and learning centers. Alternatives: Newer-generation antihistamines such as loratadine (Claritin) and cetirizine (Zyrtec) are better tolerated by older patients and do not present the same risks to memory and cognition.
This Is Your Brain on Drugs
The medicines you take can have a surprising effect on memory, but it's not just the ones your doctor prescribes. Over-the-counter medications such as Benadryl and other antihistamine allergy medications also can lead to temporary brain fog and forgetfulness.
Common anticholinergic drugs like Benadryl linked to increased dementia risk. A report published in JAMA Internal Medicine several years ago highlighted a link between long-term use of anticholinergic medications like Benadryl and dementia.
Taken together, it is likely that antihistamines primarily affect the speed of information processing, but not the integrity of information processing in working memory. The role of histamine in memory functioning remains unclear.
One study has reported a more serious long-term effect, a 3.5-fold increase in the risk of gliomas, a common type of brain tumor in patients with long-term antihistamine use for allergic conditions.
For people with year-round symptoms, taking allergy medications every day may be necessary and it's safe, according to Yul D. Ejnes, MD, MACP, a board-certified internal medicine specialist and chair of the American Board of Internal Medicine.
Official answer. Yes, most people can take antihistamines every day, if they have daily symptoms of their allergies. The number of times you take an antihistamine each day depends on the type of antihistamine.
There are some potential side effects and there are some cases where long-term antihistamine use can worsen urinary retention or narrow angle glaucoma.
Though it isn't an official clinical diagnosis that would end up in a medical chart, brain fog can arise after several sleepless nights, while taking certain medications like antihistamines, or as a result of jet lag — among many other scenarios.
Introduction: The five-word test (5WT) is a serial verbal memory test with semantic cuing. It is proposed to rapidly evaluate memory of aging people and has previously shown its sensitivity and its specificity in identifying patients with AD.
Allergy Medications
First generation antihistamines, while very effective at controlling symptoms, are often associated with symptoms in older adults such as anxiety, confusion, sedation, blurred vision, reduced mental alertness, urinary retention and constipation.
Many people using this medication do not have serious side effects. Tell your doctor right away if you have any serious side effects, including: difficulty urinating, fast/irregular/pounding heartbeat, shaking (tremor), mental/mood changes (such as anxiety, confusion, nervousness, restlessness), weakness.
Cetirizine and levocetirizine have been linked to rare, isolated instances of clinically apparent acute liver injury.
Long term use of some antihistamines may increase your risk of dementia. Diphenhydramine (Benadryl®) blocks the effects of a neurotransmitter called acetylcholine. This neurotransmitter is vital for memory and learning.
Cetirizine can be taken at any time of the day. In most people it is non-sedating, so they take it in the morning. However, a percentage of people do find it to be sedating so if it does make you drowsy it is best to take it in the evening. Cetirizine can be taken with or without food.
Is it okay to take ZYRTEC® over a long period of time? The ZYRTEC® package label doesn't state a limit on how long you can take ZYRTEC®. Talk to your doctor if you have any questions, especially if you're taking other medicines or being treated for any other conditions.
Common causes
Lyndsay shared some: Depression, anxiety and stress – “These are common causes of forgetfulness,” Lyndsay said. “Stress and mood disturbances can act as a distraction and make it difficult to focus, which can lead to memory problems.”
Health care providers often use a brief test such as the Short Test of Mental Status, the Montreal Cognitive Assessment (MoCA) or the Mini-Mental State Examination (MMSE). More detailed testing may help determine the degree memory is impaired.
Sandoz issued a voluntary recall of 1,023,430 units of Zyrtec (10 mg) capsules as a result of failed impurities and a specification being reported for impurity at the 21-month stability time point, according to an FDA Enforcement Report.
Dr Grant confirms that many people can suffer withdrawal symptoms if they stop taking antihistamines suddenly. Dr Grant recommends the patient resume taking the antihistamines and then slowly reduce the dose to wean off slowly.
However, Zyrtec does occasionally have some side effects, the most common of which are drowsiness, dizziness, fatigue, and headaches. There have been reports, through few studies, of withdrawal symptoms in people attempting to stop taking Zyrtec. These people report unbearable pruritus (itching) and/or hives.