The simple answer is no. Claire and Jamie don't have any more children after Brianna. Claire heads through the stones while pregnant with Brianna at the end of the second season/book. She spends 20 years in the 20th century, and she and Frank don't have any children together.
Jamie marries Claire to keep her from falling into the hands of the evil Captain "Black Jack" Randall. They have one child, Faith, who doesn't survive birth; an adopted son named Fergus; and a daughter, Brianna.
Claire and Jamie only have two biological children together: Faith and Brianna. Faith was the stillborn baby in France.
The Fiery Cross
Claire and Jamie care for her and give her goat's milk, keeping her warm as they bring her into Brownsville. Once in Brownsville, they find a nursing mother to feed the child, and Richard Brown makes the executive decision to take her in and raise her as his.
Outlander series
He is a dwarf and some of the residents of Fraser's Ridge believe he is a punishment for his parents' sins. Henri-Christian is placed in a basket and put into a stream by some boys. Roger saves him and baptized him.
The simple answer is no. Claire and Jamie don't have any more children after Brianna. Claire heads through the stones while pregnant with Brianna at the end of the second season/book. She spends 20 years in the 20th century, and she and Frank don't have any children together.
Claire Meets Jamie's Son and Saves Lord John Grey on Outlander - Outlander Season 4 Episode 6.
Just as she begins to worry that Jamie might be capable of lying to her, Jamie quells her fear by revealing to her his indiscretion with Mary MacNab, a woman who worked at Lallybroch, while Claire was back in 1968 with Frank and Brianna. This confession soothes Claire, and the two find themselves realigned once again.
Outlander fans were left devastated after couple Jamie and Claire were forced apart by historical events at the end of season two. Claire went back through the stones and to the 20th century where she was reunited with her first husband Frank Randall (Tobias Menzies).
After the dust has settled, and with assistance from Ned Gowan, Jamie's marriage to Laoghaire is declared invalid – as Claire was clearly still alive – and he agrees to pay her a yearly fee and provide a dowry for each of her two daughters.
Because yes, Claire and Lord John end up married in book seven, and yes, they drunkenly (and full of grief for the loss of Jamie, whom they both love with all of their heart) consummate that marriage. And then Jamie shows up alive and well!
Brianna and Roger grow their family in Go Tell the Bees That I Am Gone. It turns out that they do have another baby.
When Claire returns to the past, she and Jamie reconnect and begin to live as man and wife once again. But some might be wondering what the legal implications of Jamie's marriage to Laoghaire might mean. Given he remarried after Claire, it seems possible their marriage might be void after all.
For instance, Lord John Grey learns the truth about Claire, Brianna, and Roger... though he has a hard time believing it. And speaking of Roger and Brianna, they get into their own time-travel trouble — Roger with his ancestor Buck and Brianna with Rob Cameron.
Claire Fraser was born on October 20, 1918.
That would make her 27-and-a-half at the time she and Jamie meet in the books, while Jamie's barely 22. This would make Claire five and a half years older than Jamie.
Jamie does admit he's slept with someone else, telling her about his one-night tryst with Mary MacNab (Emma Campbell-Jones) before he turned himself in to authorities following the Battle of Culloden nearly 20 years prior.
Some think Jamie's spirit (but not his body) traveled to through time to guide Claire to him; others suggest Jamie had a near-death experience after the Battle of Culloden, and that's why his ghost is 25 when he appears to Frank.
Jamie doesn't really help matters by choosing this moment to confess that he has cheated – but not with Malva. Instead, he spent one night with someone else before going to prison, long ago (and when separated from Claire by 200 years).
Since the age of six, William has been raised by Lord John Grey, his legal guardian and husband of Geneva's younger sister, Isobel Dunsany.
While Brianna knows who William is, William does not yet know that Jamie is his father and that Brianna is his sister. He doesn't discover the connection until late in book seven, when he finds himself in Jamie's company and finally sees the resemblance between them.
Grey falls in love with Jamie, who rejects his advances. Still, Grey cannot dismiss his feelings.
When Brianna travels to 18th-century Scotland, she marries Roger MacKenzie. They have a son, Jeremiah "Jemmy" Fraser MacKenzie, and a daughter, Amanda MacKenzie.
He may never have called Jamie “Dad,” but Jamie has been the only father figure he's ever known. He's always looked up to Jamie, and this moment shows that Jamie continues to respect Fergus and call him family.
Claire technically has three husbands when you read all eight current Outlander books.