Background: Schizophrenia patients are typically found to have low IQ both pre- and post-onset, in comparison to the general population. However, a subgroup of patients displays above average IQ pre-onset. The nature of these patients' illness and its relationship to typical schizophrenia is not well understood.
Background: Schizophrenia is consistently associated with lower IQ compared to the IQ of control groups, or estimated premorbid IQ.
We have recently shown the distribution of ID in a large cohort of schizophrenia patients. Consistent with previous studies, approximately 30% of schizophrenia patients had a decline of less than 10 points, i.e., normal intellectual performance. In contrast, approximately 70% of patients showed deterioration of IQ.
Recently, neuropsychological findings were reported from a group of individuals with schizophrenia who had a mean estimated pre-morbid IQ of 120 [Reference MacCabe, Brébion, Reichenberg, Ganguly, McKenna and Murray21].
Of 129 individuals with first-episode schizophrenia or schizoaffective disorder, 25% showed stable low IQ, 31% showed stable IQ in the average/high range, and 44% demonstrated intellectual deterioration by 10 points or more.
So while treatment with some antipsychotics seems to increase intelligence, others reduce symptoms without that effect. Other medications that are known to cause improved cognitive functioning had no effect when combined with those antipsychotics.
While schizophrenia typically causes hallucinations and delusions, many people with the disorder also have cognitive deficits, including problems with short- and long-term memory.
People with schizophrenia generally live about 15 to 20 years less than those without the condition. Schizophrenia is a complex disease. There are many ways it can result in serious complications.
Schizophrenia is a serious mental disorder in which people interpret reality abnormally. Schizophrenia may result in some combination of hallucinations, delusions, and extremely disordered thinking and behavior that impairs daily functioning, and can be disabling. People with schizophrenia require lifelong treatment.
Even highly creative people with schizophrenia tend to be incapacitated during active phases of the illness while being much more productive before its onset and during later phases of remission. Many more highly creative people, while not themselves suffering from schizophrenia, have close relatives who do or did.
Compared to controls, patients with schizophrenia had significantly smaller gray matter intracranium and total brain volumes, increased 4th ventricle volumes, and greater temporal and occipital ADCs.
Most studies of schizophrenia show a life expectancy reduction of 10–20 years. A 2017 systematic review and meta-analysis found that schizophrenia correlated with an average of 14.5 years of potential life lost per person.
Although in general IQ tests have only limited diagnostic value in schizophrenia, the finding of a substantial decline in IQ score from the estimated premorbid level may be helpful in supporting a provisional diagnosis of early schizophrenia in cases without organic signs in which the clinical picture is unclear or ...
Schizophrenia affects the way you think and cope with daily life. Someone living with schizophrenia may experience hallucinations, delusions, disorganised thinking and lack motivation for daily activities.
What are the causes of mental subnormality? Mental retardation could occur due to genetic causes such as metabolic disorders, deficiency of metabolic enzymes, hypothyroidism, syndromes such as Down's syndrome, Fragile-X syndrome, Prader-Willi syndrome.
People with schizophrenia tend to have cognitive impairments related to thinking and learning; these symptoms of the illness have a great impact on social functioning.
Patients may be more aggressive and violent during acute episodes. Schizophrenic patients have less insight, experience greater thought disorder, and have poorer control of their aggressive impulses. Comorbidity with alcohol or other substances of abuse is frequent and complicates the agitation and the impulsivity.
Schizophrenia does not mean split personality or multiple-personality. Most people with schizophrenia are not any more dangerous or violent than people in the general population.
Results: In most countries, the standardized mortality rate in schizophrenia is about 2.5, leading to a reduction in life expectancy between 15 and 20 years. A major contributor of the increased mortality is due to CVD, with CVD mortality ranging from 40 to 50% in most studies.
Schizophrenia itself isn't life-threatening. But people who have it are more likely to have other health conditions that raise their chances of death. The 2015 study found that heart disease was the top cause of death in people with schizophrenia, accounting for about a quarter of all cases.
Having schizophrenia could affect your ability to drive. If you've had or currently suffer from a medical condition or disability that may affect your driving you must tell the Driver & Vehicle Agency (DVA).
The Brain In Schizophrenia
The fluid-filled spaces (the ventricles) in the interior of the temporal lobes are often enlarged and the temporal lobe tissue diminished. The greater the observed changes the greater the severity of the person's thought disorder and his or her auditory hallucinations.
Schizophrenia has been described as the “worst disease” to afflict mankind. It causes psychosis, which is an abnormal state of mind marked by hyperarousal, overactivation of brain circuits, and emotional distress. An untreated episode of psychosis can result in structural brain damage due to neurotoxicity.
Schizophrenia (SZ) is a severe psychiatric illness associated with an elevated risk for developing Alzheimer's disease (AD). Both SZ and AD have white matter abnormalities and cognitive deficits as core disease features.