Denosumab decreases bone resorption and bone loss by inhibiting RANKL, a protein essential for the activation and function of osteoclasts. Patients should continue taking prescribed calcium and vitamin D supplements.
People undergoing Prolia therapy need to receive calcium 1000mg daily and at least 400 IU of vitamin D daily.
Monitoring of calcium levels should be conducted: - Prior to each dose of Prolia. - Within two weeks after the initial dose in patients predisposed to hypocalcaemia (e.g. patients with severe renal impairment, creatinine clearance <30ml/min).
Pain, specifically musculoskeletal pain, is one of the most common side effects of Prolia. Musculoskeletal pain refers to pain in your bones, muscles, tendons, and ligaments. Bone pain from Prolia may be most noticeable in your arms and legs.
Dental side effect of receiving Prolia
Prolia has a side effect in patients who have to have tooth extractions performed. The trauma of the extraction on the bone surrounding the tooth may lead to a condition where the bone dies off, and following the extraction fragments of dead bone are lost from the extraction site.
Denosumab (brand name Prolia) is a medication used to treat severe osteoporosis. It works by turning off the natural process of breaking down and reabsorbing bones. It is administered through a shot twice per year for up to 10 years.
How long can I stay on Prolia for? For Prolia to work well at reducing fractures it needs to be taken long term and in one phase 2 clinical trial it has been used safely for up to 8 years with substantial increase in bone density, although most clinical trials are for 3 or 4 years.
High-risk individuals should continue or switch therapy after 5 to 10 years of use. Non-high-risk individuals may stop denosumab if they have no history of prior fractures, a T-score >–2.5, and low Fracture Risk Assessment Tool (FRAX) scores.
The most common side effects of Prolia are fatigue (45%), body weakness and lack of energy (45%), back pain (35%), low phosphate levels (32%), nausea (31%) and diarrhea (20%).
Once Prolia has been stopped, BMD returned to approximately baseline levels within 12 months. Prolia is a targeted treatment that is given by injection under the skin (subcutaneously) once every six months.
Skin problems such as inflammation of your skin (dermatitis), rash, and eczema have been reported. Bone, joint, or muscle pain. Some people who take Prolia® develop severe bone, joint, or muscle pain.
If you are on Prolia and are otherwise in good health, you can have a dental surgery provided the surgeon does what is called an atraumatic surgery, where they are extra cautious about traumatizing or heating the bone.
Denosumab may lower the calcium levels in the blood. If blood calcium levels are low before receiving denosumab, the low calcium level must be corrected before giving the medicine or it will get worse. Patients need to have a blood test after each dose to confirm that blood calcium level is not abnormally low.
And in trials of people taking cancer treatments that affect certain hormones (such as testosterone and estrogen), 6% of people who took Prolia had muscle or bone pain. In comparison, 3.8% of people who took a placebo had this type of pain. * Sex and gender exist on spectrums.
It is possible for people to treat or prevent osteoporosis without medication in some cases. If a person's osteoporosis has not caused too much bone loss, lifestyle changes can help prevent osteoporosis bone breaks. These changes include exercise, nutrition, and stopping smoking and drinking.
Prolia is a medicine that may affect your immune system. People who have weakened immune system or take medicines that affect the immune system may have an increased risk for developing serious infections.
The most common side effects of Prolia® in patients with glucocorticoid-induced osteoporosis are back pain, high blood pressure, lung infection (bronchitis), and headache.
Bisphosphonates are usually the first choice for osteoporosis treatment. These include: Alendronate (Fosamax), a weekly pill. Risedronate (Actonel), a weekly or monthly pill.
If you receive a Prolia injection you can't have any serious dental work done until 6 months after your injection.
Prolia has an average rating of 2.7 out of 10 from a total of 321 reviews for the treatment of Osteoporosis. 14% of reviewers reported a positive experience, while 79% reported a negative experience.