BP-lowering effects of atorvastatin were consistent in both daytime and nighttime periods. This study shows a mild, but consistent throughout the 24-h period BP-lowering effect of atorvastatin in patients with mild hypertension and hypercholesterolaemia.
Conclusion: Statins lower blood pressure by cholesterol-independent mechanisms, and the reduction is larger in individuals with higher blood pressure and those with low HDL-C. Statins may be beneficial in preventing hypertension and may contribute to better blood pressure control in hypertensive patients.
Statins work by slowing your body's production of cholesterol, which affects plaque accumulation in your arteries. Lower cholesterol means lower blood pressure, resulting in reducing your risk of a heart attack or stroke.
Take atorvastatin once a day. You can choose to take it at any time, as long as you stick to the same time every day. This prevents your blood levels from becoming too high or too low. Sometimes doctors may recommend taking it in the evening.
This is because the enzyme which makes the cholesterol is more active at night. Also, the half-life, or the amount of time it takes for half the dose to leave your body, of some statins is short.
Avoid eating foods high in fat or cholesterol, or atorvastatin will not be as effective. Avoid drinking alcohol. It can raise triglyceride levels and may increase your risk of liver damage. Grapefruit may interact with atorvastatin and lead to unwanted side effects.
Some medicines can affect the way atorvastatin works and can increase the chances of you having serious side effects, such as muscle damage. Tell your doctor or pharmacist if you are taking any of the following medicines: antibiotics such as erythromycin, clarithromycin, rifampicin or fusidic acid.
The top-selling statins are atorvastatin (Lipitor), lovastatin (Mevacor), rosuvastatin (Crestor) and simvastatin (Zocor). How they can cause insomnia: The most common side effect of all types of statins is muscle pain, which can keep people who take them awake at night and unable to rest.
Remember that this medicine will not cure your high blood pressure but it does help control it. Therefore, you must continue to take it as directed if you expect to lower your blood pressure and keep it down.
Conclusions: Atorvastatin increases HRV, decreases QTV, and shortens QTc interval, and may thereby reduce the risk of arrhythmias in patients with advanced heart failure.
Statins are the most widely prescribed and effective medication for reducing low density lipoprotein cholesterol. Statins may also lower resting blood pressure (BP); however, results are inconsistent.
If you've made lifestyle changes through diet and exercise that have lowered your cholesterol levels, you may not need to continue taking a statin. These changes can help reduce your risk of heart attack, stroke, or blocked arteries while allowing you to take one less medication.
Clinical studies revealed Lipitor can damage liver function, and the FDA has received rare post-marketing reports of both fatal and nonfatal liver failure. Other reported liver problems include jaundice, hepatitis, chronic liver damage and fatty changes to the liver.
Atorvastatin competitively inhibits 3-hydroxy-3-methylglutaryl-coenzyme A (HMG-CoA) reductase. By preventing the conversion of HMG-CoA to mevalonate, statin medications decrease cholesterol production in the liver.
Background: Adenosine receptor activation is essential for mediating the IS-limiting effects of statins. Caffeine is a nonspecific adenosine receptor blocker, and thus drinking CC may block the myocardial protective effects of statins.
Grapefruit juice can affect some statins and increase your risk of side effects. A doctor may advise you to avoid it completely or only consume small quantities. The doctor will also ask you how much alcohol you drink before prescribing statins.
Cholesterol-Lowering Drugs
The ones that can cause sun sensitivity include: simvastatin (Zocor) atorvastatin (Lipitor) lovastatin (Mevacor)
Research indicates that statins may reduce the supply of energy to the cells in the muscles, which could cause people to feel tired.
Reports of increased daytime urination were similarly higher. The odds of a statin-user reporting nocturia appeared to be greatest among those taking lovastatin (Mevacor), followed by rosuvastatin (Crestor), simvastatin (Zocor), pravastatin (Pravachol), and lastly, atorvastatin (Lipitor).
Statin use is associated with increased calorie intake and consequent weight gain. It is speculated that statin‐dependent improvements in lipid profile may undermine the perceived need to follow lipid‐lowering and other dietary recommendations leading consequently to increased calorie intake.