The findings from this research suggest that vitamin B12 and folic acid may have the potential to positively impact liver health, specifically when it comes to individuals with fatty liver disease. These particular nutrients, in the form of supplements, may even hold the possibility of reversing fatty liver disease.
Using non-human models, they showed clearly that vitamin B12 and folate reduced liver inflammation and liver scarring (fibrosis) in NASH. These agents appear to act by affecting the homocysteine pathway. This is not a well-studied pathway. Homocysteine appears to be raised in NASH with its metabolism reduced in NASH…”
All individuals with renal illness are advised to take vitamin B12 because it is water-soluble. Additionally, most people with chronic liver disease also have hyperhomocysteinemia, which is a sign of vitamin B deficiency and necessitates the use of B12 and B9 supplements.
Methylation–and therefore detoxification–are dependent on the B vitamins to work properly (4). This process helps your liver and other detox organs convert and excrete unwanted toxins from your body. The B vitamins are also necessary to make glutathione, your body's most powerful antioxidant.
If you don't have a vitamin B12 deficiency, most of the vitamin B12 you get through your injection will be absorbed and eliminated quickly through your urine. This accounts for the people in the research that found 98% of their injected vitamin B12 in their urine 48 hours after it was administered.
Look for supplements that contain natural and scientifically proven ingredients that support liver health, such as milk thistle, turmeric, dandelion root, and artichoke extract. These ingredients have been shown to have liver-protective properties, stimulate liver regeneration, and aid in detoxification.
Vitamin B12 is an essential nutrient that helps the body create DNA, nourishes the brain and nervous system, and assists with the formation of healthy red blood cells. The nutrient occurs naturally in meat, fish, and dairy products, and can be created in a laboratory.
Vitamin B12, or cobalamin, is naturally found in animal foods. It can also be added to foods or supplements. Vitamin B12 is needed to form red blood cells and DNA. It is also a key player in the function and development of brain and nerve cells.
We found highly significant positive correlations between vitamin B12 and the hepatocellular enzymes GGT, GLDH, ASAT and ALAT.
Remove Toxic and Inflammatory Foods
Water and diet are the first places to start detoxing your liver. Caffeine, alcohol, processed foods with refined sugar, unhealthy fats, additives, and preservatives do the opposite of detoxing your liver. You should also remove inflammatory foods such as gluten and dairy.
While the recommended daily amount of vitamin B-12 for adults is 2.4 micrograms, higher doses have been found to be safe. Your body absorbs only as much as it needs, and any excess passes through your urine. High doses of vitamin B-12, such as those used to treat a deficiency, might cause: Headache.
The current study showed that supplementation with vitamin B12 (1000 µg cyanocobalamin per day) for 12 weeks among patients with NAFLD improved serum levels of homocysteine. Also, the fasting blood glucose and serum levels of MDA were significantly improved in the trial group who received vitamin B12.
On one hand, a lack of vitamin B12 blocks the synthesis of S-adenosylmethionine (SAM), which results in the production of methionine synthase. However, SAM is the main cellular antioxidant in the liver, and a lack of SAM may cause liver damage and differentiation.
If you're at risk for vitamin B12 deficiency, the following can provide some protection: Supplements. Even the lowest doses in B12 supplements are many times the recommended dietary allowance. Doses up to 1,000 mcg, though unnecessary, aren't harmful.
You may feel tired and weak. High amounts of vitamin B12 can also cause you to feel like your hands and feet are tingling. Some studies suggest that taking 25 mcg or more per day might increase your risk of bone fractures. Vitamin B12 injections should only be used to treat severe deficiencies.
Vitamin C and B12
According to Dr. Airey, some studies have shown that Vitamin C could break down Vitamin B12 in your digestive tract, reducing your B12 absorption. As a result, he says you want to wait at least two hours before taking Vitamin C with your Vitamin B12.
B12 is required as a cofactor by gut microbes for various biological processes, including acetate production via the Wood-Ljungdahl pathway, and for the conversion of succinate to propionate.