Results: Outpatients who received cetirizine and hydroxyzine treatments reported higher scores on the depression, anxiety, and fatigue sub-scales than those who received desloratadine, levocetirizine, and rupatadine.
Histamine H1 receptor antagonist cetirizine impairs working memory processing speed, but not episodic memory - PMC.
One study of 92 people with chronic itchiness saw that patients who took the antihistamines cetirizine and hydroxyzine reported an increase in depression and anxiety. The effects of all antihistamines on mood disorders have yet to be studied.
One study also suggests cetirizine and hydroxyzine have a greater chance of causing anxiety and mood changes than other antihistamines.
Certain allergy and asthma medications. The over-the-counter allergy medication cetirizine (Zyrtec and generic) has been linked to depression, as has another type of drug, montelukast (Singulair), which is often used to treat people with allergic asthma.
A headache, sore throat, abdominal pain, fatigue, drowsiness, or coughing. Other side effects are uncommon. Generally does not cause drowsiness, although more likely to do so at higher dosages. Caution should be exercised before driving or operating machinery until the full effects of cetirizine are known.
Cetirizine led to a significant reduction of all histamine-induced parameters and abolished serotonin-induced wheals. Conclusions: Serotonin has an own pruritic potency and does not only act over histamine containing mast cells.
Antihistamines may make young children sleepy or may stimulate the nervous system, causing hyperactivity. Don't give antihistamines to your child unless you've checked with the doctor first.
Hydroxyzine's unique effect on serotonin is likely why it's the only antihistamine used for anxiety. While hydroxyzine can be used to treat many different types of anxiety disorders, it is used most often for generalized anxiety disorder (GAD), especially when it is associated with insomnia.
You should not use this medication if you are allergic to or had an adverse reaction to cetirizine. Before taking cetirizine, tell your doctor about all of your medical conditions or if you have ever had kidney or liver disease. Cetirizine is not expected to be harmful to an unborn baby.
People who take antihistamines regularly may build up a tolerance to the drug, which means they need to take higher and higher doses to get the same effect. This can lead to addiction. Antihistamines are often addictive because they work by blocking histamine receptors.
This Is Your Brain on Drugs
The medicines you take can have a surprising effect on memory, but it's not just the ones your doctor prescribes. Over-the-counter medications such as Benadryl and other antihistamine allergy medications also can lead to temporary brain fog and forgetfulness.
About 50 or 60% of cetirizine eliminated in the urine is unchanged. It is eliminated in the urine via an active transport mechanism. The elimination half-life of cetirizine ranges from 6.5 to 10 hours in healthy adults, with a mean across studies of approximately 8.3 hours. Its duration of action is at least 24 hours.
And oral corticosteroids like prednisone, which are commonly used to treat severe allergies, can cause irritability and can increase the risk of developing symptoms of anxiety or depression. Nasal decongestants like the ones found in Sudafed and Sudafed PE can cause anxiety, nervousness and insomnia.
Claritin and Zyrtec are popular over-the-counter antihistamines. Doctors consider them safe and effective treatments for minor allergies. Both are second-generation antihistamines. These cause less drowsiness than first-generation antihistamines.
Results: Outpatients who received cetirizine and hydroxyzine treatments reported higher scores on the depression, anxiety, and fatigue sub-scales than those who received desloratadine, levocetirizine, and rupatadine.
Antihistamine Risks and Anticholinergic Syndrome
This leads to significant central nervous system side effects, including sedation, drowsiness, somnolence, fatigue, cognitive decline, psychomotor effects, and loss of coordination.
Although second-generation antihistamines have minimal anticholnergic activity compared with first-generations, they may cause central nervous system effects, including psychosis.
Cetirizine is an antihistamine medication that treats allergy symptoms like itchy eyes, sneezing, a stuffy nose or hives. A common brand name for this medication is Zyrtec®.
Dystonic movements are thought to be due to imbalances in cholinergic stimulation. Cetirizine is a piperazine derivative and the authors postulated that the dystonia may have been due to its dopamine receptor blocking properties.
Official answer. Yes, most people can take antihistamines every day, if they have daily symptoms of their allergies.
Common Zyrtec side effects may include:
feeling hot, sweating; numbness, tingling, burning pain; altered sense of taste; upset stomach, constipation; or.
by Drugs.com
Cetirizine can be taken at any time of the day. In most people it is non-sedating, so they take it in the morning. However, a percentage of people do find it to be sedating so if it does make you drowsy it is best to take it in the evening. Cetirizine can be taken with or without food.
It's generally safe to take the newer generation of antihistamines daily if you have year-round allergy symptoms. But make sure to avoid anything that has a "D" in its brand name, which stands for decongestants. Long-term use of decongestants will worsen your allergy symptoms.