Although more studies are needed, some research suggests that CoQ10 may help reduce low-density lipoprotein (LDL) cholesterol and total cholesterol levels in people with diabetes, lowering their risk of heart disease.
Adult. For adults 19 years and older: The recommended dose for CoQ10 supplementation is 30 to 200 mg daily. Soft gels tend to be better absorbed than capsules or other preparations. Higher doses may be recommended for specific conditions.
Using random-effect model, the pooled results for lipid profiles showed that CoQ10 supplementation significantly decreased total cholesterol (SMD -1.07; 95% CI, − 1.94, − 0.21, P = 0.01; I2 = 94.9%) and increased HDL-cholesterol levels (SMD 1.30; 95% CI, 0.20, 2.41, P = 0.02; I2 = 94.7%).
A 12-week study in 50 people with diabetes found that those who received 100 mg of CoQ10 per day had significant reductions in blood sugar, markers of oxidative stress and insulin resistance, compared to the control group ( 27 ). Doses of 100–300 mg of CoQ10 per day appear to improve diabetes symptoms ( 28 ).
Recent studies show that CoQ10 supplements can significantly increase HDL-C and ApoA1 levels, even in people taking statins, and may help reduce risk for CVD. CoQ10 supplementation also lowers levels of inflammatory biomarkers shown to be risk factors for CVD, such as high-sensitivity C-reactive protein.
CoQ10 supplements appear to be safe and to produce few side effects when taken as directed. Mild side effects might include digestive problems such as: Upper abdominal pain. Loss of appetite.
Risks. People with chronic diseases such as heart failure, liver problems, or diabetes should be wary of using this supplement. CoQ10 may lower blood sugar levels and blood pressure.
In some cases, doses may be gradually increased to 3000 mg per day. For heart failure and fluid build up in the body (congestive heart failure or CHF): 30 mg once daily, or up to 300 mg per day divided into two or three doses for up to 2 years. Also, 2 mg/kg daily for up to one year has been used.
CoQ10 supplements aren't necessary for everyone. “If you have a balanced diet, and if you're young and healthy, you probably have enough CoQ10 in your body,” Peart says.
If you have been taking CoQ10 supplements while trying to conceive or through fertility treatments, we recommend stopping as soon as you are pregnant UNTIL you discuss it with your doctor.
Soluble fiber can reduce the absorption of cholesterol into your bloodstream. Soluble fiber is found in such foods as oatmeal, kidney beans, Brussels sprouts, apples and pears. Add whey protein. Whey protein, which is found in dairy products, may account for many of the health benefits attributed to dairy.
ANSWER: Although a coenzyme Q10 supplement may be helpful for some people who take a statin medication, no research studies have confirmed that it has benefits for everyone who takes statins.
Afterwards researchers tested how well blood flowed through the arteries of people in the study. The results were encouraging. The CoQ10 supplement improved blood vessel health by about 42%, so the researchers thought this meant that the risk of heart disease was lowered by 13%.
If you eat sources of saturated fat, like beef, switching to foods with omega-3 fatty acids, like fatty fish, can help lower your heart disease risk. CoQ10 may offer benefits if you already struggle with cardiovascular disease risk or you've had a heart attack.
There's no standard guideline for the best time to take CoQ10. However, the general rec is to take CoQ10 in the morning with a meal, due to its potential energizing effects. * But like all supplements, CoQ10 isn't one-size-fits-all—so it's possible that a later-in-the-day dose might work for you.
Due to it's antioxidative effects, research has found that CoQ10 reduces inflammation in the body. This is significant because so many diseases are caused by inflammation. We are realizing that inflammation is often due to our poor health habits, insufficient sleep, and… you guessed it – lack of nutrients!
CoQ10 supplementation is associated with increased energy levels. As with other supplements that boost energy levels, CoQ10 users have reported side effects such as slight stomach upset, headaches, feeling jittery or “wired,” and experiencing mild insomnia.
There are no apparent interactions between vitamin D and CoQ10, showing they're safe to supplement together. Some studies show that CoQ10 and vitamin D are beneficial for supporting heart health and exert protective effects on cardiovascular and renal health.
In addition to reducing the risk of cardiovascular problems in patients with liver disease, CoQ10 supplementation may also benefit the disease process within the liver by reducing inflammation and oxidative stress.
Is CoQ10 safe? Taking 100 mg a day or more of CoQ10 has caused mild insomnia in some people. And research has detected elevated levels of liver enzymes in people taking doses of 300 mg per day for long periods of time. Liver toxicity has not been reported.
Plasma CoQ10 levels were significantly increased following 2 weeks of CoQ10 supplementation (p < 0.001); while a trend for higher muscle CoQ10 levels was observed after acute CoQ10 ingestion (p = 0.098).
For our patients, daily supplementation of CoQ10 can lead to doubling their weight loss over several months with the same calorie intake. Also, CoQ10 improves stamina and motivation to exercise, which further helps to achieve an optimal weight.
Similarly, CoQ10 supplementation improves glycaemic control and vascular dysfunction in type II diabetes, improves renal function in patients with chronic kidney disease, and reduces liver inflammation in patients with non-alcoholic fatty liver disease.
Drug Interactions and Additive Effects
On the other hand, some studies have shown that CoQ10 has done the complete opposite to Vitamin K Antagonists and actually enhanced the anti-blood-clotting effect, which leads to excessive bleeding.