Not everyone gains a lot of weight while taking prednisone, but most people gain some. The increases should stop once you're on a lower dosage or off the drug. Then you can focus on a healthy lifestyle that'll help you shed the extra pounds.
Prednisone is one of several medications known to cause weight gain. This is usually more likely to happen with long-term use or higher doses. For example, about 70% of people in one study who took oral corticosteroids (including prednisone) for over 60 days reported weight gain.
The majority of patients who take steroids long-term will experience weight gain, even as early as six months into treatment.
Because corticosteroids, such as prednisone, impact hormones, they can affect men and women differently. Women are more likely to develop osteoporosis, a serious side effect from prednisone use. And women who are pregnant, who want to get pregnant or who are breastfeeding should not take prednisone.
Steroid drugs, such as prednisone, work by lowering the activity of the immune system. The immune system is your body's defense system. Steroids work by slowing your body's response to disease or injury. Prednisone can help lower certain immune-related symptoms, including inflammation and swelling.
Fluid retention is one of prednisone's most famous side effects. “'Moon face' is common, which is swelling in the face that can occur after you've been on steroids for a long time,” Dr. Ford notes. “You can also get swelling in the legs and midsection.”
Common side effects
If you have to take prednisolone for more than a few weeks, it's likely that you'll put on weight. Prednisolone can make you hungrier and also can make you retain more water in your body. Try to eat well without increasing your portion sizes.
A gradual reduction in prednisone dosage gives your adrenal glands time to resume their usual function. The amount of time it takes to taper off prednisone depends on the disease being treated, the dose and duration of use, and other medical considerations. A full recovery can take a week to several months.
As you eat more over time, you gain more weight. Also, your body retains more fluid while taking Prednisone, causing you to experience water retention and swelling. If you have an inflammatory condition that may restrict movement, this can mean you are inactive for a period of time, resulting in added weight gain.
Can steroids make you gain weight? Steroids affect your metabolism and how your body deposits fat. This can increase your appetite, leading to weight gain, and in particular lead to extra deposits of fat in your abdomen.
The drug is highly effective but can cause weight gain, muscle wasting, and other serious side effects. A new study in mice has found that a weekly dose of the same drug may have the opposite effect, building muscle strength and promoting weight loss.
Fluid retention can cause weight gain but as steroids are reduced, fluids will usually reduce as well, along with some of the weight gain. Drinking plenty of water and exercising can help with fluid retention.
“When the patient stops taking the prednisone, fat distribution goes back to normal and moon face disappears after a few weeks,” Dr. Galligan says. And, again, this kind of swelling isn't harmful, so moon face is actually a relatively minor potential side effect of prednisone.
The dose of prednisolone you'll take depends on your health problem and whether you are taking it as a short course or for longer. The usual dose varies between 5mg and 60mg daily but occasionally higher doses may be prescribed. The strength of tablets range from 1mg to 25mg.
Weight gain is a common side effect of prednisone. Prednisone can also cause a redistribution of fat to the face, back of the neck and the abdomen, although these changes vary from person to person.
Moon face may appear within the first two months of steroid therapy, though the risk of developing it depends on dosage and length of treatment.
Mild side effects that have been reported with prednisone include: edema (swelling due to excess fluid) muscle weakness. bloating (swelling due to excess fluid or gas, often in the abdomen)
There's no official definition. But over 30 days is generally considered long-term steroid use. Most often, oral corticosteroids are prescribed for roughly 1 to 2 weeks — and only for very severe symptoms. But for certain chronic health conditions, corticosteroids may be necessary for months or even years.
Things to avoid (or cut back on) while taking prednisone include: Caffeine: Caffeine can add to the unwanted stimulant effects of prednisone. Combining caffeine with steroids can keep you awake at night or make you feel jittery and anxious.
Sodium and Fluids
Although you can add some salt to your dishes, avoid adding too much when you're taking prednisone. This also means reducing your intake of foods that contain high amounts of salt, such as canned foods, pickles, potato chips, crackers, and bacon.
Prednisone affects areas of the brain that manage the regulation of different neurotransmitters, including serotonin and dopamine — the “feel-good” hormones. Feeling happy is a great side effect some people feel with prednisone.
Some products that may interact with this drug include: aldesleukin, mifepristone, drugs that can cause bleeding/bruising (including antiplatelet drugs such as clopidogrel, "blood thinners" such as dabigatran/warfarin, NSAIDs such as aspirin/celecoxib/ibuprofen).