The scientific evidence is mixed when it comes to using magnesium during brain injury recovery. Some studies show mild benefits in early TBI treatments, but most do not display any positive effects. However, there is also no evidence that magnesium is harmful, if you are not taking certain medications.
Magnesium is one of the most essential nutrients in the human body. It plays a vital role in nerve regeneration and functional recovery by reducing the inflammation and causing Schwann cell proliferation at the injury site, which increases axonal recovery.
As it is similar to Ca2+, this element can also act as a cell signaling molecule and play multiple important roles in the nervous, muscle, and immune systems. Recent studies have associated Mg-deficiency with many neurological disorders, such as cerebral vasospasm, Alzheimer's disease, stroke, and migraine.
The study of more than 6,000 cognitively healthy participants in the United Kingdom aged 40 to 73 found people who consume more than 550 milligrams of magnesium each day have a brain age that is approximately one year younger by the time they reach 55 compared with someone with a normal magnesium intake of about 350 ...
Stress And Anxiety Relief
Magnesium may be the “chill pill” you need. Magnesium plays a role in regulating the hypothalamic-pituitary-adrenal axis (HPA axis), our stress response system, and deficiencies in the mineral have been shown to induce anxiety and HPA axis dysregulation in an animal model.
Some animal studies have found that magnesium threonate is more effective at increasing magnesium ions in the brain and improving cognitive function than magnesium sulfate. Therefore, doctors may recommend magnesium L-threonate to normalize an individual's magnesium levels and for potential benefits to the brain.
The fourth most abundant mineral in your body, magnesium is essential for hundreds of enzyme reactions that affect everything from bones and blood sugar to nerves and brain cells.
In conclusion, Mg supplementation may significantly reduce different human inflammatory markers, in particular serum CRP and NO levels.
Magnesium deficiency is diagnosed via a blood test and sometimes a urine test. Your doctor may order the blood test if you have symptoms such as weakness, irritability, abnormal heart rhythm, nausea and/or diarrhoea, or if you have abnormal calcium or potassium levels.
Generally speaking, you will find that magnesium supplements start to work after one week of using them. After one week of regular magnesium supplementation, individuals may experience benefits such as improved energy levels, reduced muscle cramps, better sleep quality, and reduced anxiety.
B vitamins are known for their ability to support healthy nervous system function. Vitamins B-1, B-6, and B-12 have been found to be especially beneficial for treating neuropathy. Vitamin B-1, also known as thiamine, helps to reduce pain and inflammation and vitamin B-6 preserves the covering on nerve endings.
Consuming more magnesium, on the other hand, helps relieve inflammation and promote faster regeneration of injured tissues.
How long does it take for magnesium to reduce anxiety? In most cases, magnesium starts working within a week, since it's a fast-acting nutrient. You need to take it consistently to reduce anxiety and help you relax.
One study. View Source of older adults with insomnia found that magnesium supplementation at a dose of 500 milligrams daily for eight weeks helped them fall asleep fast, stay asleep longer, reduced nighttime awakenings, and increased their levels of naturally circulating melatonin.
Magnesium is able to cross the BBB (Sacco et al., 2007), and it is transported via the barrier with a net flux from the blood into the parenchyma.
Magnesium is involved in several physiological processes in the psychoneuroendrocrine system and modulates the hypothalamic pituitary adrenal (HPA) axis, along with blocking the calcium influx of NMDA glutamatergic receptors, all of which help prevent feelings of stress and anxiety [72].
In addition, there is some evidence magnesium can potentially benefit mental health by acting as a mood booster, muscle relaxer, stress reducer, and sleep aid.
Magnesium is an important mineral that helps maintain a healthy mood. Low levels of magnesium are associated with fatigue, anxiety, and depression. Research shows that adults, as well as children, don't get enough magnesium and that this may be linked to climbing rates of mood and mental health problems.
Mg2+ may decrease intensity of addiction by many mechanisms. Mg2+ decreases synaptic delivery of all catecholamines including dopamine (essential for molecular mechanism of morphine-induced addiction), with dopamine release being stimulated by excitatory amino acids. A low brain magnesium level favors dopamine release.
Magnesium can directly reduce dopamine release at the presynaptic level and can also reduce the stimulatory effect of glutamate on dopamine release.
"Serotonin and melatonin are crucial in determining your mood. Magnesium works as an important co-factor required for conversion of tryptophan (from proteins we get from food) to serotonin and melatonin, both of which help in falling asleep."