In addition to helping control blood sugar levels, Ozempic lowers glucagon, a hormone that raises sugar levels. As a result, Ozempic may promote weight loss, but it has not been approved for that purpose.
Does Ozempic affect hormones? Ozempic does affect your hormones, mainly by mimicking the natural hormone produced by your gut called GLP-1.
Ozempic works by mimicking a naturally occurring hormone. As those hormone levels rise, the molecules go to your brain, telling it you're full. It also slows digestion by increasing the time it takes for food to leave the body. This is similar to the effect of bariatric surgery.
It helps regulate the hormones insulin and glucagon when blood sugar levels are high. It also slows gastric emptying, so you feel full longer. At higher doses, semiglutide acts on the brain to decrease appetite.
Ozempic is a semaglutide drug used clinically to manage type 2 diabetes. This drug mimics a naturally occurring hormone (gop1) released by the gut that increases insulin secretion and helps regulate appetite. Gop1 is released in the body after eating to make you feel full and signal the brain to stop eating.
The most common side effects of Ozempic, according to the drug's website, are nausea, stomach pain, constipation, diarrhea and vomiting. Novo Nordisk, the maker of Ozempic and Wegovy, told CBS News that the drugs "are a well-established class of medicines, which have demonstrated long-term safety in clinical trials.
We know that Ozempic works to help your body regulate its food, sugar and fat metabolism, but there are other health benefits that were also discovered during the drug trials.
In rare cases, the use of Ozempic may cause anxiety and mood swings, irritability, shakiness, and confusion. However, when you take other medications along with Ozempic, it may escalate anxiety or mood change. Hence, discuss these potential issues with your physician beforehand to avoid any side effects.
On the other hand, some studies suggest that Ozempic could have potential negative effects on fertility by altering hormone levels.
Ozempic and its sister medication, Wegovy — approved for weight loss for people who are obese or overweight with weight-related medical conditions — are considered long-term or lifelong treatments.
You may need a higher dosage of Ozempic
The same holds true for Ozempic's weight loss results. People taking higher doses of Ozempic tend to lose more weight. In the landmark study we cited above, people lost 7% of their body weight, on average, within a year and a half of taking 1mg of semaglutide.
The active ingredient in Ozempic is semaglutide, which works by inducing satiety. This feeling of being satisfied or “full”, suppresses appetite. This is why it works for weight loss. Semaglutide also helps the pancreas produce insulin, which is how it helps manage type 2 diabetes.
Ozempic is a type 2 diabetes medication which is prescribed to manage blood glucose levels. It is not a medication for people who do not have diabetes or are at risk of type 2 diabetes.
The most common side effect with Ozempic is nausea and occurs in about 15% to 20% of people. Others include vomiting (5% to 9%), diarrhea (8%), stomach-area pain (6% to 7%), and constipation (3% to 7%).
You start feeling those usual hunger pangs again, and consequently, you may start eating more to satisfy that hunger. An increase in your consumption can lead to the regaining of weight that was lost. A 2022 study found that most individuals gain weight back a year after stopping the medication.
A person can stay on Ozempic® so long as they are tolerating the medication and it is deemed appropriate by their treating provider. There is no specific time frame when someone should stop taking Ozempic as it is a medication that is intended for chronic (long-term) use.
While Ozempic wasn't developed or approved for treating polycystic ovarian syndrome (PCOS), it and similar drugs may be promising tools to help some people manage PCOS symptoms if prescribed off-label.
It is not known if Ozempic® will cause thyroid tumors or a type of thyroid cancer called medullary thyroid carcinoma (MTC) in people. Do not use Ozempic® if you or any of your family have ever had MTC, or if you have an endocrine system condition called Multiple Endocrine Neoplasia syndrome type 2 (MEN 2).
If you stop taking Ozempic, the weight you lost will likely return, fast. People who ceased use of semaglutide gained back, on average, a full two-thirds of the weight they had lost on the drug within one year, according to an August 2022 study, the Wall Street Journal reports.
If Ozempic wasn't mainstream before, it definitely is now – Jimmy Kimmel joking about A-listers using the drug during the 2023 Oscars proved as much. Elon Musk and Amy Schumer have admitted to taking the weight-loss drug while other celebrities, such as Khloé Kardashian and RHOBH star Kyle Richards, have denied it.
Semaglutide (Ozempic, Wegovy, Rybelsus) can cause side effects that some people are unable to tolerate. Following dosing guidelines can help manage these side effects. Nausea, vomiting, and diarrhea are the most common semaglutide side effects. But they usually subside after a few weeks of using the medication.
Ozempic is used off-label for weight loss and belly fat reduction, as it helps make you feel fuller for longer and can lead to a reduction in calories consumed. Studies have shown that this medication can lead to an average weight loss of 7.5% and a decrease in waist circumference by 5.09 cm.