Progesterone can help increase your mood. Progesterone acts as a natural antidepressant to lower anxiety, help with mood swings, and can even aid in relieving postpartum depression. Progesterone can relieve menopause symptoms.
For most women, progesterone is good for mood because it converts to a neurosteroid called allopregnanolone which calms GABA receptors. Progesterone's calming neurosteroid effect is why progesterone capsules are usually tranquillizing and why times of high progesterone (luteal phase and pregnancy) can cause sleepiness.
Progesterone also stimulates GABA, the feel-good/stay-relaxed neurotransmitter that's also affected by the thyroid. When progesterone levels drop, GABA levels can drop too leading to feelings of both anxiety and depression.
A 2012 study showed that increased levels of progesterone you experience in the luteal phase of your menstrual cycle is usually accompanied by lower levels of aggression, irritability and fatigue (1).
With natural progesterone, you may notice some changes and symptoms like breast tenderness, headaches, and depression. But these symptoms are generally more associated with synthetic progesterone. If you do experience these symptoms, they generally go away as you continue taking natural progesterone.
Progesterone acts as a natural antidepressant, enhances mood and relieves anxiety. It has a calming effect on the brain. It stimulates the brain's GABA receptors, the feel-good, calming neurotransmitters. So it is easy to understand why anxiety can surface when your progesterone levels are low.
Women take progesterone by mouth for inducing menstrual periods; and treating abnormal uterine bleeding associated with hormonal imbalance, and severe symptoms of premenstrual syndrome (PMS). Progesterone is also used in combination with the hormone estrogen to "oppose estrogen" as part of hormone replacement therapy.
There is evidence that some women experience unpleasant mood symptoms (such as irritability, depressed mood and anxiety) while receiving hormone replacement therapy (HRT) while taking the progestin / progesterone component of the HRT.
Emerging data indicate that progesterone has multiple non-reproductive functions in the central nervous system to regulate cognition, mood, inflammation, mitochondrial function, neurogenesis and regeneration, myelination and recovery from traumatic brain injury.
Common effects of oral contraceptive pills on mood
There is evidence to suggest that both oestrogen and progesterone influence brain function, which may be responsible for the negative mood changes and depression commonly reported in women taking oral contraceptive pills.
When balanced with estrogen, progesterone has a calming effect on the brain. An imbalance of progesterone—either high or low—can cause mood swings and memory loss associated with brain fog.
Increases in estradiol and progesterone lead to enhanced motivation for access to a mate but decrease motivation for food (Cummings and Becker, 2012; Richard et al., 2017).
If you still have your uterus:
Progesterone is used along with estrogen. Taking estrogen without progesterone increases your risk for cancer of the endometrium (the lining of the uterus). During your reproductive years, cells from your endometrium are shed during menstruation.
Progesterone has been suggested to increase serotonergic neurotransmission via the regulation of the expression of serotonin-related genes and proteins (Bethea et al., 2002; Smith et al., 2004; Sanchez et al., 2005).
Progesterone has been found to stimulate dopamine release, while oestrogen has been found to inhibit dopamine actions. So clinically, these opposing actions help to regulate dopamine release, if the woman's hormones are in check.
Estrogen and progesterone have many characteristics that aid in preventing aging signs on your skin. For example, they naturally increase hyaluronic acid (HA) and prevent the loss of collagen and elastin.
Potential adverse effects of long-term use of progestin with estrogen include invasive breast cancer, heart disease-related events, dementia (including Alzheimer's disease), stroke and blood clots. Talk to your health care professional if you experience side effects.
Low levels of progesterone decrease serotonin, which can result in poor sleep and depression. Also, diminished amounts of progesterone prevent the balancing of the stimulating effects of estrogen and can lead to anxiety..
Small, short-term clinical trials of progesterone show no meaningful effect on cognition. The quality of evidence is low, but overall findings do not reveal consistent, clinically important effects of progesterone on cognitive function in women.
The drop in estrogen and progesterone that occurs at the end of a women's menstrual cycle may cause anxiety and other mood symptoms. This is similar to the drop experienced during perimenopause, the time during which your body makes the natural transition to menopause.
Progesterone's role in breast development has yet to be proven. Reported increases in breast size seem most likely due to general weight gain and fat deposition in the breasts as caused by pro- gesterone and estrogen, and not the direct effect of progesterone on the breast tissue itself.
The most noticeable manifestation of low progesterone levels is irregular periods and short cycles, but sometimes symptoms like premenstrual spotting may appear. Other symptoms may include mood changes, sleep disturbances, anxiety, and depression. Progesterone affects the regulation of fluid levels in the body.
Note that taking progesterone can cause side effects, including the following: Headaches. Breast tenderness or pain. Vomiting.
Using large doses of this medicine over a long period of time and using it with an estrogen medicine may increase your risk of heart attack, stroke, blood clots, or dementia. Talk with your doctor about these risks. Your risk of heart disease or stroke from this medicine is higher if you smoke.
Estrogen and Progesterone
These hormones also help with hair growth. Estrogen and progesterone can help keep your hair in the growing (anagen) phase. Therefore, these hormones can help your hair stay on your head longer and may even help your hair grow faster.