No blood test can definitively prove or rule out a diagnosis of rheumatoid arthritis, but several tests can show indications of the condition. Some of the main blood tests used include: erythrocyte sedimentation rate (ESR) – which can help assess levels of inflammation in the body.
Anti-cyclic citrullinated peptide antibody (anti-CCP).
This blood test checks for anti-CCP antibodies, which appear in many people with rheumatoid arthritis. In addition, anti-CCP can appear before RA symptoms develop, which can help doctors diagnose the disease early.
A person with RA may feel intense pain in their joints during flares. This can feel like sustained pressure, a burning sensation, or a sharp pain. However, people with RA may also experience periods of remission when they feel few to no symptoms. In addition to causing joint pain, RA can affect the whole body.
If your GP thinks you have rheumatoid arthritis, they will refer you to a specialist (rheumatologist). Your GP may arrange blood tests to help confirm the diagnosis after conducting a physical examination and consulting your medical history, or they may refer you at the same time as requesting tests.
The symptoms of rheumatoid arthritis often develop gradually over several weeks, but some cases can progress quickly over a number of days. The symptoms vary from person to person. They may come and go, or change over time. You may experience flares when your condition deteriorates and your symptoms become worse.
Lupus and Scleroderma
The autoimmune diseases systemic lupus erythematosus and scleroderma are two separate conditions but often present with joint involvement that mimics rheumatoid arthritis.
What's the age of onset for rheumatoid arthritis? RA usually starts to develop between the ages of 30 and 60. But anyone can develop rheumatoid arthritis. In children and young adults — usually between the ages of 16 and 40 — it's called young-onset rheumatoid arthritis (YORA).
Rheumatoid Arthritis and Lifespan
In the study, the median survival rate for healthy adults was approximately 82 years while the median survival rate for people with RA was approximately 77 years.
People with rheumatoid arthritis typically have several permanently inflamed joints. The inflammation inside the body can lead to general physical weakness, drowsiness and exhaustion. This feeling of extreme tiredness is also called "fatigue." Some people find this to be the worst symptom of the disease.
At-home rheumatoid factor (RF) testing: At-home rheumatoid factor testing detects levels of rheumatoid factor in the blood. Testing kits allow patients to obtain a sample of blood using a finger stick. Once a sample of blood is collected in a test vial, it's sent to a laboratory for analysis.
Anti-CCP antibody test (ACCP or CCP). This test is for a type of autoantibody called cyclic citrullinated peptide (CCP) antibodies, which can be found in the blood of 60% to 80% of people with rheumatoid arthritis. The test is often conducted along with an RF test.
Multiple sclerosis and rheumatoid arthritis share similar symptoms, so one condition can be mistaken for the other. However, this is rare because diagnostic testing methods vary between two conditions.
Key Points about Rheumatoid Arthritis
The joints most often affected by RA are in the hands, wrists, feet, ankles, knees, shoulders, and elbows. Symptoms may include joint pain, stiffness, and swelling; decreased and painful movement; bumps over small joints; and fatigue or fever.
If rheumatoid arthritis is not treated early or is not well controlled, the inflammation in your joints could lead to significant and permanent damage. Problems that can affect the joints include: damage to nearby bone and cartilage (a tough, flexible material that covers the surface of joints)
Rheumatoid arthritis can be difficult to diagnose because many conditions cause joint stiffness and inflammation and there's no definitive test for the condition. See a GP if you have these symptoms so they can try to determine the cause.
Rheumatoid arthritis can be one of the most painful types of arthritis; it affects joints as well as other surrounding tissues, including organs. This inflammatory, autoimmune disease attacks healthy cells by mistake, causing painful swelling in the joints, like hands, wrists and knees.
Doctors usually diagnose arthritis using the patient's medical history, physical examination, X-rays, and blood tests. It is possible to have more than one form of arthritis at the same time. There are many forms of arthritis, and diagnosing the specific type you have can help your doctor determine the best treatment.
OA usually affects fewer joints, and its symptoms are generally limited to the joints. The progression of RA is more difficult to predict, and it can cause more widespread symptoms. The outlook for people with RA has greatly improved due to advances in research and therapies.
Although there's no cure for rheumatoid arthritis, early treatment and support (including medicine, lifestyle changes, supportive treatments and surgery) can reduce the risk of joint damage and limit the impact of the condition. Your treatment will usually involve care from your GP and several different specialists.
In the early stages, people with RA may not see redness or swelling in the joints, but they may experience tenderness and pain. These symptoms are clues to RA: Joint pain, tenderness, swelling or stiffness that lasts for six weeks or longer. Morning stiffness that lasts for 30 minutes or longer.