The hyperpigmentation related to vitamin B12 deficiency is more common in darker-skinned patients. Few other cases of skin hyperpigmentation due to vitamin B12 deficiency have been reported in the literature. The mechanism of hyperpigmentation is due to increased melanin synthesis rather than a defect in melanin.
Vitamin B12 (cobalamin): B12 boosts the radiance of dull and mature skin. This B vitamin also helps to diminish the look of dark spots and uneven skin tone.
Vitamins can be used to lighten your skin and lighten dark spots. Three of the best vitamins for lightening dark spots are vitamin C, vitamin B12, and vitamin E. Vitamin C helps your skin produce more collagen while inhibiting the formation of melanin.
Subsequently, the patient had been receiving a MVI tablet daily containing Vitamin B12 (1 mg) and showed improvement in his presentation [Figure 4]. Usually, hyperpigmentation resolves within 3 months of initiation of treatment, in about 87% of such patients.
It is suggested that deficiency of vitamin B12 causes decrease in intracellular reduction potential that leads to oxidation of the reduced glutathione and decrease in GSH/GSSG ratio. The epidermal melanocytes are then stimulated to produce melanin as the tyrosinase inhibiting effect of GSH has been diminished.
Dermatologists consider products with hydroquinone, alone or combined with other lighteners, to be the gold standard for fading dark spots because it slows the production of pigment.
If you have anaemia caused by a vitamin B12 deficiency, you may have other symptoms, such as: a pale yellow tinge to your skin.
However, supplementing with excessively high levels of B12 has been linked to some negative side effects. Several studies have shown that megadoses of the vitamin can lead to outbreaks of acne and rosacea, a skin condition that causes redness and pus-filled bumps on the face.
It may take a few weeks before your vitamin B12 levels and symptoms (such as extreme tiredness or lack of energy) start to improve. If you have hydroxocobalamin injections to boost your vitamin B12 levels at the start of treatment, the cyanocobalamin tablets may start to work within a few days.
The skin is a multi-layered organ which requires collagen and other fatty acids to maintain its structure. B vitamins assist with fatty acid production. Supplementation can lead to more youthful looking, glowing skin.
Vitamin D is then taken up by your liver and kidneys and transported throughout the body to help create healthy cells. This includes the skin, where vitamin D plays an important role in skin tone.
Vitamin B Complex (Biotin and Niacin) Gives You a Vibrant Look. Vitamin B complex, which includes several types of vitamins, is known to be essential for maintaining healthy skin. One of those vitamins, Vitamin B7 (also known as “biotin”), helps the body break down and process fats and other substances.
Urban Skin Rx's Even Tone Cleansing Bar is our best overall pick for its dermatologist recommended formula that contains azelaic acid, kojic acid, and niacinamide—all actives that have been proven to fade spots.
Melanocytes in the basal epidermis control skin pigmentation through synthesis of melanin, a complex process thought to be primarily regulated by alpha-melanocyte stimulating hormone (αMSH) (Figure 1—figure supplement 1A and B).
Vitamin B-12 deficiency is one of the most common causes of prematurely graying hair. Researchers have noted that vitamin B-12 deficiencies are often concurrent with folic acid and biotin deficiencies in people whose hair has started to turn gray early.