Vitamins B6 and B12 have also been proven to boost melanin production. Goddard says that vitamin B6, also known as pyridoxine, has been found to trigger the production of enzymes and chemical reactions that boost the metabolism of the hair proteins (keratin and melanin) in the hair follicles.
It is suggested that deficiency of vitamin B12 causes decrease in intracellular reduction potential that leads to oxidation of the reduced glutathione and decrease in GSH/GSSG ratio. The epidermal melanocytes are then stimulated to produce melanin as the tyrosinase inhibiting effect of GSH has been diminished.
Brightens skin
Vitamin B12 (cobalamin): B12 encourages cells to reproduce, evening skin tone, and brightening dull and dark spots. It also helps reduce inflammation, acne and can treat skin conditions like eczema.
Vitamin C is a naturally occurring substance and an essential nutrient. It has various biological and pharmaceutical functions. It inhibits melanin synthesis through downregulation of tyrosinase enzyme activity.
Subsequently, the patient had been receiving a MVI tablet daily containing Vitamin B12 (1 mg) and showed improvement in his presentation [Figure 4]. Usually, hyperpigmentation resolves within 3 months of initiation of treatment, in about 87% of such patients.
Dermatologists consider products with hydroquinone, alone or combined with other lighteners, to be the gold standard for fading dark spots because it slows the production of pigment.
Use of strong oxidizing agents, such as permanganate, chlorate, chromic acid, peroxide, and peracetic acid, will bleach melanin, although the process is slow, taking 16 hours. The blacker the melanin, the longer the bleach takes to decolorize the pigment.
Vitamin C-based skin care products may lighten patches that are darker than the rest of your skin, called hyperpigmentation. In one study, vitamin C applied to the skin for 16 weeks significantly cut down on these spots.
Vitamin C is an effective skin lightener that has been described as a melanogenesis inhibitor due to its inhibition of tyrosinase and reduction of melanin and melanin intermediates, such as dopaquinone.
What it does: B12 is necessary for cell reproduction and can be applied topically for skin benefits because it reduces inflammation, dryness, and acne. It is sometimes used to treat conditions like psoriasis and eczema.
Vitamin B-12 deficiency is one of the most common causes of prematurely graying hair. Researchers have noted that vitamin B-12 deficiencies are often concurrent with folic acid and biotin deficiencies in people whose hair has started to turn gray early.
Vitamin B Complex can work to improve overall skin health and even reduce acne and breakouts. Increasing the amount of Vitamin B complex in your body can improve energy, amino acid metabolism, and facilitate steps required for cell division.
If your body makes too little melanin, your skin gets lighter. Vitiligo is a condition that causes patches of light skin. Albinism is a genetic condition affecting a person's skin. A person with albinism may have no color, lighter than normal skin color, or patchy missing skin color.
Vitamin D is then taken up by your liver and kidneys and transported throughout the body to help create healthy cells. This includes the skin, where vitamin D plays an important role in skin tone.
Vitamin A. Studies suggest vitamin A is important to melanin production and is essential to having healthy skin. You get vitamin A from the food you eat, especially vegetables that contain beta carotene, such as carrots, sweet potatoes, spinach, and peas.
Autoimmune conditions
If you have non-segmental vitiligo, your immune system destroys the melanocyte skin cells that make melanin. Vitiligo is also associated with other autoimmune conditions, such as hyperthyroidism (an overactive thyroid gland), but not everyone with vitiligo will develop these conditions.
Melanin can be extracted as such by alkali or water, but cleavage from protein moiety renders the melanin insoluble in all solvents [130]. They are insoluble in common organic solvents, aqueous acids, and water.
It is possible to lighten your skin with lemon juice. It is due to the high concentration of vitamin C, a powerful antioxidant. Lemon juice contains vitamin C that reduces melanin, resulting in lighter skin. A 2017 study found that vitamin C can reduce tyrosinase activity, which prevents the formation of melanin.
Urban Skin Rx's Even Tone Cleansing Bar is our best overall pick for its dermatologist recommended formula that contains azelaic acid, kojic acid, and niacinamide—all actives that have been proven to fade spots.
exfoliate. This is the first step to speed up cell turnover and remove the damaged, overly pigmented and dead skin cells. Using a gentle yet effective chemical exfoliator like with Quick Refiner every night will also help your skin to absorb the key ingredients of the brightening products much better.
When those skin cells are damaged or unhealthy, they can produce too much melanin. The melanin can clump, causing that area to appear darker. Many things can lead to hyperpigmentation: Adrenal disorders such as Addison's disease, when the body doesn't make enough of a hormone called cortisol.
Vitamin B12 deficiency may be associated with a number of pigment changes. Typically, these involve hyperpigmentation, mostly localized in the dorsum of the hands, fingers and feet and sometimes in skin folds and mucosal surfaces.
Cutaneous manifestations associated with vitamin B12 deficiency are skin hyperpigmentation, vitiligo, angular stomatitis, and hair changes.