This study showed that vitamin D administration is associated with an increase in adiponectin and a decrease in leptin level in ESRD patients.
Moreover, Vitamin D is known as a major cellular and molecular factor in leptin gene expression in the adipose tissue, which can also affect energy homeostasis (34). Increasing leptin is one of the factors regulating appetite, followed by weight loss in obese and overweight people (34).
Vitamin A was positively associated with leptin (p < 0.05). When stratifying by BMI, % body fat and waist circumference, high leptin concentrations were associated with lower zinc and lower vitamin C concentrations in women with obesity (p < 0.05) and higher vitamin A concentrations in women without obesity (p < 0.01).
In other words, the less body fat, the less leptin you have, and the more body fat, the more leptin you have. Leptin levels increase if your fat mass increases over time, and they decrease your fat mass decreases over time.
You don't get usable leptin from food, and there's no evidence that specific foods help boost the hormone. But a poor diet or extra pounds may make the hormone less effective (leptin resistance). A healthy, balanced diet and regular exercise may help keep this problem at bay.
High protein intake: A diet that's high in protein may increase leptin sensitivity, increase feelings of fullness, and lower body weight (Weigle, 2005). Avoiding triglycerides: A type of fat called triglycerides, found in foods like butter and oil, can block leptin signals and lead to leptin resistance (Banks, 2004).
Leptin receptor deficiency is a condition that causes severe obesity beginning in the first few months of life. Affected individuals are of normal weight at birth, but they are constantly hungry and quickly gain weight. The extreme hunger leads to chronic excessive eating (hyperphagia) and obesity.
Leptin resistance not only contributes to the body's ability to absorb more food, but also signals to the brain that the body needs to conserve energy, which in turn limits calorie burning. Therefore, supplementing with blood leptin levels does not actually lead to weight loss.
The liver and kidneys convert vitamin D (produced in the skin and taken up in the diet), into the active hormone, which is called calcitriol(1,25-dihydroxyvitamin D).
Vitamin D, a secosteroid (pro)-hormone, has been traditionally considered as a key regulator of bone metabolism, and calcium and phosphorous homeostasis through a negative feedback with the parathyroid hormone.
The reduction in sex hormones among the women with the highest levels of vitamin D was observed even after taking into account how much weight the women lost, showing that the vitamin D had an independent effect on hormone levels, regardless of pounds shed.
Sulforaphane reduces obesity by reversing leptin resistance.
Various studies have shown that a person's blood leptin level drops after a low-kilojoule diet. Lower leptin levels may increase a person's appetite and slow down their metabolism.
Leptin isn't a vitamin or mineral. You can't absorb it from a pill. In fact, “leptin supplements” don't contain any actual leptin. If they did, your stomach would simply digest them before they could have any effect on your body.
Fasting and energy-restricted diets elicit significant reductions in serum leptin concentrations. Increases in adiponectin may also be observed when energy intake is ≤50% of normal requirements, although limited data preclude definitive conclusions on this point.
Leptin is a hormone released from fat cells in adipose tissue. Leptin signals to the brain, in particular to an area called the hypothalamus. Leptin does not affect food intake from meal to meal but, instead, acts to alter food intake and control energy expenditure over the long term.
Exercise training-induced reductions in leptin levels have been attributed to alterations in energy balance, improvements in insulin sensitivity, alterations in lipid metabolism, and unknown factors. Hormone replacement does not seem to affect leptin adaptations to training.
However, taking too much vitamin D in the form of supplements can be harmful. Children age 9 years and older, adults, and pregnant and breastfeeding women who take more than 4,000 IU a day of vitamin D might experience: Nausea and vomiting. Poor appetite and weight loss.
The team found a “positive correlation” between vitamin D and estradiol. In other words, women with lower levels of vitamin D tended also to have lower levels of estradiol, and women with higher levels of vitamin D tended also to have higher levels of estradiol.