At the same time, the serum calcium level displayed a significant positive correlation with the vitamin D level in our study, boosting the likelihood of myocardial infarction in patients with vitiligo, especially in those with autoimmune disease.
Vitiligo is an autoimmune disease. This type of disease develops when your immune system attacks part of your own body. If you have vitiligo, your immune system attacks cells in your body called melanocytes. These are cells that make pigment.
About 15 to 25 percent of people with vitiligo are also affected by at least one other autoimmune disorder, particularly autoimmune thyroid disease, rheumatoid arthritis, type 1 diabetes, psoriasis , pernicious anemia, Addison disease, systemic lupus erythematosus, celiac disease, Crohn disease, or ulcerative colitis.
Psoriasis and hidradenitis suppurativa are commonly associated with CVD, sharing common inflammatory pathways and a higher prevalence of traditional cardiovascular risk factors.
Warning signs and symptoms of heart failure include shortness of breath, chronic coughing or wheezing, swelling, fatigue, loss of appetite, and others. Heart failure means the heart has failed to pump the way it should in order to circulate oxygen-rich blood throughout the body.
In summary, these observations make it pretty clear that vitiligo is an autoimmune disease that is initiated by melanocyte stress, which can be worsened by exposure to chemicals. Genes, inherited from your parents, influence all of these pieces.
Vitiligo is caused by the lack of a pigment called melanin in the skin. Melanin is produced by skin cells called melanocytes, and it gives your skin its colour. In vitiligo, there are not enough working melanocytes to produce enough melanin in your skin. This causes white patches to develop on your skin or hair.
Protect your skin from the sun.
A bad sunburn can worsen vitiligo. If you have a lighter skin tone, there's another advantage to protecting your skin from the sun. Without a tan, the lighter spots and patches are often less noticeable.
The disease does not affect life expectancy. However, it can have a significant impact on quality of life, especially psychologically and be responsible for disorders such as depression and anxiety.
Many people who have vitiligo are often otherwise healthy. Even so, it's important to find a doctor like a dermatologist who knows about vitiligo. People who have vitiligo have a higher risk of getting some other medical conditions. You can also get painful sunburns on the skin that has lost color.
As non-segmental vitiligo is closely associated with other autoimmune conditions, you may be assessed to see whether you have any symptoms that could suggest an autoimmune condition, such as: being tired and lacking energy (signs of Addison's disease) being thirsty and needing to urinate often (signs of diabetes)
Vitiligo is associated with several comorbid autoimmune, systemic, and dermatological diseases, primarily thyroid disease, alopecia areata, diabetes mellitus, pernicious anemia, systemic lupus erythematosus, rheumatoid arthritis, Addison's disease, inflammatory bowel disease, Sjögren's syndrome, dermatomyositis, ...
medwireNews: Patients with the autoimmune disorder vitiligo have a “markedly reduced” risk for developing malignancies of internal organs compared with other individuals, Korean researchers report.
Vitiligo is an autoimmune disease of the skin, which means that someone with vitiligo has an immune system that is malfunctioning in a small way. The normal role of the immune system is to protect you from infections and cancer.
Stress increases the levels of catecholamines, neuropeptides, and cortisol that are higher in vitiligo patients [37–39] suggesting their role in the pathogenesis of vitiligo.
A 2016 study found that 20% of participants with vitiligo had an autoimmune disease. The most common of these was thyroid disease, at 12.9%. The reverse is also true – in a 2009 study, vitiligo was significantly more common in people with a thyroid disease than a control group.
To the best of our knowledge, vitamin D significantly affects melanocytes and keratinocytes. Studies suggest that vitamin D3 increases tyrosinase activity and melanogenesis in vitro [12], which may lead to repigmentation in vitiligo skin lesions.
Complications of vitiligo are social stigmatization and mental stress, eye involvement like iritis, depigmented skin is more prone to sunburn, skin cancer, and hearing loss because of loss of cochlear melanocytes. Other complications are related to medications like skin atrophy after prolonged use of topical steroids.