The zinc chelator N,N,N′,N′-tetrakis(2-pyridylmethyl)ethylenediamine (TPEN) inhibits the release of histamine, the production of cytokines, and the secretion of lipid mediators in mast cells, and zinc supplementation rescues these inhibitory effects.
Vitamin B6 and Vitamin C, in particular, have been shown to reduce symptoms of seasickness and histamine intolerance.
ZINC AS A STABILIZING AGENT ON MAST CELLS
The role of zinc on the release of histamine from mast cells in vivo [Cho and Ogle, 1977; Ogle and Cho, 1977a, b] and in vitro [Kazimierczak and Maslinski, 19741 is established. However, its function in the storage of histamine is not clear.
These findings suggest that zinc deficiency participates in increased histamine levels in dialysis patients, and subsequently in the development of uremic pruritus.
Aside from dietary changes, there is no set treatment for people with histamine intolerance. However, one or more of the following approaches may help: taking antihistamines. taking DAO enzyme supplements.
Zinc has shown to play an important role in histamine intolerance, as it impacts how your body stores histamine. Zinc deficiency has shown to allow a higher release of histamine. Concentrated zinc has actually shown the capacity to prevent histamine release from mast cells and normalize immune responses.
Zinc is another mineral you should ensure you're getting enough of because it is important in appropriate mast cell signalling. Stress reduction is also important in stabilising mast cells.
Natural antihistamines may help you control your seasonal allergies. Common ones are stinging nettle, vitamin C, quercetin, butterbur, bromelain, and probiotics. Some alternative practices—such as acupuncture, nasal irrigation, and exercise—may also help you manage symptoms.
Magnesium is also needed to make the enzyme, DAO, which mops up histamine when it's been released, if you can't make DAO, histamine levels in the blood increase 16. Histamine release from immune cells causes many of the symptoms of allergic responses to, for example, pollen and insect bites.
Studies suggest that vitamin B12 can trigger histamine release in the body. Certain bacteria or yeasts can convert histidine into histamine in the body, triggering an allergic reaction. Fermented foods high in certain types of microorganisms can trigger a histamine allergy in the body.
Vitamin C is a natural antihistamine, which means it can lower histamine levels and mitigate allergic reactions and symptoms. Consume plenty of Vitamin C rich foods, like tropical fruits, citrus fruits, broccoli and cauliflower, and berries.
Block and reduce nighttime histamine release
You can block nighttime histamine release and get a better night's sleep by taking 0.25 -1 mg of ketotifen or zaditen at night.
Zinc maintains healthy nervous system function, especially looking after the vagus nerve, which connects the brain to the body, through which messages of 'calm' are transported. A healthy nervous system connection can support the easing of anxiety.
Zinc is an Antioxidant and Anti-Inflammatory Agent: Its Role in Human Health.
Zinc is very calming and sedating, as it enhances GABA activity in the brain. A number of studies also show that zinc deficiency causes depression-like and anxiety-like behaviors, and supplementation has successfully been used as a treatment (48-53).
Your body doesn't need a large amount of zinc. The recommended daily allowance for adults is 8 - 11 mg. It's common to have slightly low levels of zinc, but taking a multivitamin, plus eating a healthy diet, should give you all the zinc you need.
What are the symptoms of zinc deficiency? Zinc deficiency can result in skin changes that look like eczema at first. There may be cracks and a glazed appearance on the skin, often found around the mouth, nappy area and hands. The rash doesn't get better with moisturisers or steroid creams or lotions.
Some experts believe that a deficiency in vitamin B6 and C is linked with histamine intolerance; these vitamins have been shown to relieve histamine intolerance symptoms.
Boswellia, also known as frankincense, is a potent anti-inflammatory herbal medicine that can help to stabalise mast cells and reduce histamine load in the body.
Histamine intolerance (HIT) is assumed to be due to a deficiency of the gastrointestinal (GI) enzyme diamine oxidase (DAO) and, therefore, the food component histamine not being degraded and/or absorbed properly within the GI tract.
For these people, histamine builds up in the body and is not broken down correctly. This can trigger an immune system response resulting in symptoms such as diarrhea, shortness of breath, headaches, or skin irritation.
Greg Panico, a spokesman for Janssen Pharmaceutica, which is owned by Johnson and Johnson, said that the withdrawal was a voluntary business decision. “The decision to voluntarily discontinue it recognises that the allergy marketplace is crowded with a number of other drugs,” Mr Panico said.