Zinc is another mineral you should ensure you're getting enough of because it is important in appropriate mast cell signalling. Stress reduction is also important in stabilising mast cells.
Zn is essential for FcεRI-mediated cytokine production in mast cell and transcription of IL-6 and TNF-α mRNA4. Zn is also known to function as an antioxidant and stabilize cell membranes3.
Studies have found that zinc can actually inhibit the release of histamine from our immune system. Zinc also plays a major role in storing histamine in the body. So, when there's a zinc deficiency, the body releases more histamine into the surrounding tissues.
Vitamin D contributes to mast cell stabilization.
Incorporate functional foods with mast cell-stabilizing properties, such as pomegranate, onion, capers, moringa, nettle, and Thai ginger (galangal).
In vitro studies have shown that quercetin stabilizes the membranes of mast cells and reduces the release of preformed histamine.
In this study, we hypothesized that magnesium, as a known calcium channel blocker, can stabilize the mast cell membrane and reduce mast cell degranulation, which could be one of the mechanisms of its effect on neuroinflammation and its analgesic effect.
Vitamin C is a powerful antioxidant and anti-inflammatory that helps reduce histamine levels by acting as a natural antihistamine and stabilizing mast cells. This can help alleviate allergy symptoms such as runny nose, itchy eyes, and wheezing.
Vitamin C has many immune boosting properties, but is distinctively beneficial for individuals with seasonal discomfort because of its ability to deactivate histamine.
Zinc is an Antioxidant and Anti-Inflammatory Agent: Its Role in Human Health.
Zinc in human plays an important role in cell mediated immunity and is also an antioxidant and anti-inflammatory agent.
Vitamin D is required to maintain the stability of mast cells, and Vitamin D deficiency results in mast cell activation.
Zinc acutely and temporarily inhibits adrenal cortisol secretion in humans.
Zinc supplementation can relieve the allergic state.
This study provided in vitro evidence for the first time that cetirizine more potently inhibited the process of exocytosis in mast cells than diphenhydramine, indicating its higher potency as a mast cell-stabilizer.
Antihistamines are the first line of treatment in MCAD. Non-sedating H1 antihistamines, eg cetirizine, loratadine, fexofenadine, are often preferred.
The findings indicate that by stabilizing mast cells and helping to block the release of histamine, vitamin B12 can help protect against inflammation-induced skin barrier damage and relieve skin sensitivity and irritations cause by environmental stress factors.
Magnesium helps your body regulate its zinc levels, while zinc enables it to absorb magnesium more efficiently. Zinc will only hinder absorption when taken in abnormally high doses (around 142 mg of zinc per day).
Magnesium is also needed to make the enzyme, DAO, which mops up histamine when it's been released, if you can't make DAO, histamine levels in the blood increase 16. Histamine release from immune cells causes many of the symptoms of allergic responses to, for example, pollen and insect bites.
Curcumin inhibits Syk kinase–dependent signaling events in mast cells and might thus contribute to its antiallergic activity. Therefore curcumin might be useful for the treatment of mast cell–related immediate and delayed allergic diseases.
Quercetin – 2000 mg daily, dose divided. Green tea (EGCG, L-Theanine) – 2 to 3 cups daily. Supplement with 500 mg (175 mg of ECGC) twice daily.
There is no cure for the condition. You will need to avoid triggers and use medications. If you have anaphylactic reactions, your doctor might also give you an auto-injector epinephrine pen to use in emergencies.