Does zoledronic acid weaken the immune system?

It has been reported that there was a long-lasting significant decrease not only of γδT cells, but also of total WBC, lymphocytes, CD4+ T cells, and eosinophils 1 year after the first infusion of zoledronic acid.

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Does zoledronic acid lower your immune system?

3.5. Effects of ZOL on anti-cancer immunity. In addition to its effects on bone cells, ZOL has profound effects on the immune system, including a plethora of immune cell subsets expressing the mevalonate pathway enzymes, leading to a general increase in anti-tumour immunity [65].

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Do bisphosphonates lower your immune system?

Bisphosphonates are well tolerated with chronic administration and have very few adverse effects. Research suggests that these medications can stimulate the immune system.

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What does zoledronic acid do to the body?

Zoledronic acid is in a class of medications called bisphosphonates. It works by slowing bone breakdown, increasing bone density (thickness), and decreasing the amount of calcium released from the bones into the blood.

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What are the long term side effects of zoledronic acid?

According to a list of zoledronic acid side-effects, dangerous side-effects such as coma, confusion, convulsions, difficult breathing, hypotension, atrial fibrillation, and cardiac arrhythmia secondary to hypocalcemia are possible [16].

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22 related questions found

Is zoledronic acid worth having?

User Reviews for Zoledronic acid to treat Prevention of Osteoporosis. Zoledronic acid has an average rating of 4.4 out of 10 from a total of 42 ratings for the treatment of Prevention of Osteoporosis. 31% of reviewers reported a positive experience, while 55% reported a negative experience.

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How long does zoledronic acid stay in your body?

Zoledronic acid medication is a long-acting drug. As such, it stays in your body longer than 12 months (probably more than 24 months). Therefore, delaying your treatment for a number of months will not put you at a higher risk of sustaining fragility fracture nor cause significant decline in your bone mineral density.

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Does zoledronic acid make you tired?

Zoledronic acid can cause flu-like symptoms such as joint and muscle pain, fatigue, shivering and fever. These can last for a few days. Your treatment team can advise you about taking mild pain relief to help.

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What happens when you stop taking zoledronic acid?

Discontinuation of therapy should be considered by doctors after 3 to 5 years in patients with osteoporosis at low risk of fracture. Patients who discontinue therapy should have their risk for fracture re-evaluated periodically.

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Who should not take zoledronic acid?

You should not be treated with zoledronic acid if you are allergic to it. You also should not receive Reclast if you have: low levels of calcium in your blood (hypocalcemia); or. severe kidney disease.

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Do osteoporosis drugs suppress immune system?

Official answer. Yes, Prolia (denosumab) does appear to weaken your immune system. Research has shown people who take Prolia are at an increased risk of serious infections leading to hospitalizations, including serious infections of the skin, abdominal, urinary tract, and ear.

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Why does zoledronic acid cause flu like symptoms?

Fever after zoledronic acid administration is due to increase in TNF-alpha and IL-6. J Interferon Cytokine Res.

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Why do we stop bisphosphonates after 5 years?

Long-term bisphosphonate therapy has been linked to a rare type of thigh fracture. This injury, known as atypical femoral fracture, is similar to a stress fracture, causing pain that begins subtly and can gradually worsen. If not identified early on, a complete fracture of the thighbone can occur.

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What can I take instead of zoledronic acid?

Alternatives to Zoledronate for Paget's Disease
  • Risedronate (oral) Bisphosphonates can also be given as tablets; these are slightly less effective than an infusion of zoledronic acid, at reducing bone remodelling, and the effect doesn't last quite as long. ...
  • Pamidronate (infusion) ...
  • Calcitonin (injection)

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Which is better prolia or zoledronic acid?

In one comparative study of zoledronic acid and denosumab, denosumab showed a greater increase in spinal bone mass density (BMD) compared to zoledronic acid. Zoledronic acid also showed a greater incidence of flu-like symptoms. Based on this study, Prolia may be more effective for certain people.

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Can zoledronic acid make you gain weight?

Tell your doctor right away if you have agitation, blood in the urine, confusion, decreased urine output, depression, dizziness, headache, irritability, lethargy, muscle twitching, nausea, rapid weight gain, seizures, stupor, swelling of the face, ankles, or hands, or unusual tiredness or weakness.

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How many zoledronic acid infusions can you have?

The usual dose is 5 mg given as one infusion per year into a vein by your doctor or nurse. The infusion will take at least 15 minutes. In case you recently broke your hip, it is recommended that Zoledronic acid 5 mg is administered two or more weeks after your hip repair surgery.

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Why is zoledronic acid given once a year?

The results of this trial indicate that a once-yearly infusion of zoledronic acid during a 3-year period significantly reduces the risk of vertebral, hip, and other fractures in patients with postmenopausal osteoporosis.

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Does zoledronic acid strengthen bones?

Zoledronate (zoledronic acid) Zoledronate is an osteoporosis medication that can help strengthen your bones and reduce your risk of breaking a bone. It is available as an annual intravenous infusion (drip). Zoledronate is a 'bisphosphonate' – a group of drugs that work by slowing down the cells that break down bone.

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Can you drink alcohol with zoledronic acid?

Check with your doctor or pharmacist before you start or stop taking any other drugs. The drinking of alcohol (in small amounts) does not appear to affect the safety or usefulness of zoledronic acid. pregnancy. It is best to use birth control while being treated with zoledronic acid.

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Can zoledronic acid cause hair loss?

Hair loss can occur with Zometa use. Hair loss can also occur with cancer treatments that you may have with Zometa. These treatments include chemotherapy or radiation therapy.

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Does zoledronic acid affect arthritis?

Abstract. Zoledronic acid is effective for osteoporosis at a single annual intravenous dose. It usually causes few adverse effects; the most common are related to acute phase reactions. We reported the case of a 64-year-old woman who presented flare-up of hand osteoarthritis after zoledronic acid infusions.

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Is zoledronic acid a hazardous drug?

CONSIDERED A HAZARDOUS SUBSTANCE ACCORDING TO OSHA 29 CFR 1910.1200. Possible risk of impaired fertility. Possible risk of harm to the unborn child. Harmful: danger of serious damage to health by prolonged exposure through inhalation.

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How effective is zoledronic acid for osteoporosis?

One death (from any cause) is prevented for every 27 patients who received zoledronic acid instead of placebo (NNT = 27; 95% CI, 15.4 to 96.3).

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Is zoledronic acid toxic?

Administration of Zoledronic Acid Injection 4 mg given as a 5-minute intravenous infusion has been shown to result in an increased risk of renal toxicity, as measured by increases in serum creatinine, which can progress to renal failure.

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