Stress reduction is also important in stabilising mast cells. When you're stressed, your body releases corticotropin-releasing hormone (CRH), which is associated with the activation of skin mast cells. Incorporate meditation, yoga, breathing exercises and other stress-reducing techniques into your daily life.
Second generation antihistamines, including loratadine, cetirizine and fexofenadine, are preferable due to fewer side effects. Treatment with histamine type 2 receptor blockers, such as ranitidine or famotidine, can be helpful for abdominal pain and nausea.
Drugs that modulate the symptoms of mast cell activation
Non-sedating H1 antihistamines, eg cetirizine, loratadine, fexofenadine, are often preferred.
This study provided in vitro evidence for the first time that cetirizine more potently inhibited the process of exocytosis in mast cells than diphenhydramine, indicating its higher potency as a mast cell-stabilizer.
Magnesium significantly reduced mast cell degranulation in the acute phase by about 23% and in the second phase by about 40%. Pearson's coefficient did not show a significant correlation between mast cell degranulation and pain under treatment with magnesium.
Incorporate functional foods with mast cell-stabilizing properties, such as pomegranate, onion, capers, moringa, nettle, and Thai ginger (galangal).
Vitamin D contributes to mast cell stabilization.
Vitamin C is a powerful antioxidant and anti-inflammatory that helps reduce histamine levels by acting as a natural antihistamine and stabilizing mast cells. This can help alleviate allergy symptoms such as runny nose, itchy eyes, and wheezing.
This abnormal growth of mast cells causes a range of symptoms, including itchy bumps on the skin, gastrointestinal (GI) issues such as diarrhea, and bone pain. It can increase the risk of anaphylaxis (a severe allergic response) when patients come across certain environmental triggers (such as a bee sting).
There is no cure for the condition. You will need to avoid triggers and use medications.
Avoid drugs that can trigger mast cell release - narcotics, muscle relaxants, certain antibiotics, anti-seizure, local anesthetics, IV dye, and certain blood pressure medicines such as ACE inhibitors and beta-adrenoceptor antagonists.
There are foods that patients with mast cell disease seems to be more reactive to overall. These include but are not limited to: Monosodium Glutamate (MSG), alcohol, shellfish, artificial food dyes and flavorings, food preservatives, pineapples, tomatoes & tomato based products, and chocolate.
The findings indicate that by stabilizing mast cells and helping to block the release of histamine, vitamin B12 can help protect against inflammation-induced skin barrier damage and relieve skin sensitivity and irritations cause by environmental stress factors.
Vitamin D is required to maintain the stability of mast cells, and Vitamin D deficiency results in mast cell activation.
Indeed, mast cells themselves have H4 receptors which when stimulated increased degranulation and cytokine production. Therefore, antihistamines targeting both the H1 and H4 receptor could be an effective treatment for mast cell-mediated allergic diseases (110).
Vitamin C has many immune boosting properties, but is distinctively beneficial for individuals with seasonal discomfort because of its ability to deactivate histamine.
Many antihistamines exhibit inhibition of mediator release from mast cells and basophils, in in vitro studies in addition to H1 antagonism.
"The active component of turmeric is curcumin, which has anti-inflammatory properties, and its anti-allergic properties are due to inhibition of histamine release from mast cells," Dr. Galowitz says.
Curcumin inhibits Syk kinase–dependent signaling events in mast cells and might thus contribute to its antiallergic activity. Therefore curcumin might be useful for the treatment of mast cell–related immediate and delayed allergic diseases.
When mast cells detect a substance that triggers an allergic reaction (an allergen), they release histamine and other chemicals into the bloodstream. Histamine makes the blood vessels expand and the surrounding skin itchy and swollen.
Zn is essential for FcεRI-mediated cytokine production in mast cell and transcription of IL-6 and TNF-α mRNA4. Zn is also known to function as an antioxidant and stabilize cell membranes3.