While most people tolerate coenzyme Q10 well, it can cause some mild side effects including stomach upset, loss of appetite, nausea, vomiting, and diarrhea. It can cause allergic skin rashes in some people. It also might lower blood pressure, so check your blood pressure carefully if you have very low blood pressure.
Several clinical studies involving small numbers of people suggest that CoQ10 may lower blood pressure. However, it may take 4 to 12 weeks to see any change.
CoQ10 has been shown to improve symptoms of congestive heart failure. Although findings are mixed, CoQ10 might help reduce blood pressure. Some research also suggests that when combined with other nutrients, CoQ10 might aid recovery in people who've had bypass and heart valve surgeries. Diabetes.
Due to it's antioxidative effects, research has found that CoQ10 reduces inflammation in the body. This is significant because so many diseases are caused by inflammation. We are realizing that inflammation is often due to our poor health habits, insufficient sleep, and… you guessed it – lack of nutrients!
CoQ10 stimulates the cell's powerhouse, an organelle called the mitochondria, to produce more energy in the form of Adenosine Triphosphate (ATP). More specifically, it speeds up the process called the electron transport chain which produces 95% of the cell's ATP.
CoQ10 works slowly, so you may not see any therapeutic benefit for up to eight weeks. Before starting any supplement, of course, you should consult your healthcare provider.
As has already been mentioned, CoQ10 is sometimes associated with fatigue.
A 12-week study in 50 people with diabetes found that those who received 100 mg of CoQ10 per day had significant reductions in blood sugar, markers of oxidative stress and insulin resistance, compared to the control group ( 27 ). Doses of 100–300 mg of CoQ10 per day appear to improve diabetes symptoms ( 28 ).
Coenzyme Q10 (CoQ10) is a popular nutritional supplement, an antioxidant and an essential component of the mitochondrial electron transport chain. Several clinical studies have suggested that fatigue can be reduced by antioxidant supplementation.
CoQ10 as an Antidepressant
Most research on CoQ10 and antidepressants have looked at the likelihood that antidepressants may deplete CoQ10 levels, but new research suggests that CoQ10 might also act in the other direction, e.g., as a natural antidepressant.
Side effects from CoQ10 seem to be rare and mild. They include diarrhea, nausea, and heartburn. Risks. People with chronic diseases such as heart failure, liver problems, or diabetes should be wary of using this supplement.
What drugs and food should I avoid while taking Coq10 (Ubiquinone (Coenzyme Q-10))? Avoid using ubiquinone together with other herbal/health supplements that can also lower blood pressure. This includes andrographis, casein peptides, cat's claw, fish oil, L-arginine, lycium, stinging nettle, or theanine.
Preclinical and clinical studies have shown that CoQ10 has anti-inflammatory and antioxidant effects, and effects on mitochondrial dysfunction, which have been linked to the inflammatory response.
As with other supplements that boost energy levels, CoQ10 users have reported side effects such as slight stomach upset, headaches, feeling jittery or “wired,” and experiencing mild insomnia. Other side effects reported less often include palpitations, anxiety, dizziness, irritability, and rarely, rashes.
What are the symptoms of CoQ10 deficiency? Whilst everyone is different, people who have a deficiency in CoQ10 levels often experience physical fatigue and muscle weakness, even while undertaking relatively non-strenuous physical activities such as walking.
Improved Brain Health
One study published in the Journal of Clinical Psychopharmacology found that in 18 people with depression found that 400 to 800 mg/day CoQ10 for a month decreased the severity of depression symptoms and significantly improved symptoms of fatigue, sadness, and difficulty concentrating or brain fog.
There's no standard guideline for the best time to take CoQ10. However, the general rec is to take CoQ10 in the morning with a meal, due to its potential energizing effects. * But like all supplements, CoQ10 isn't one-size-fits-all—so it's possible that a later-in-the-day dose might work for you.
So if you are going to try CoQ10 for fatigue, try about 300 mg a day because this is the level that has been shown to improve physical and mental fatigue in otherwise healthy people.
CoQ10, or Coenzyme Q10, is full of antioxidant properties that protect the skin from environmental stressors, energizes the skin, and helps your skin retain moisture. In addition to its ability to help even out skin tone, it helps reduce dullness and tightens up the skin.
In a study of people with high cholesterol, high triglycerides, and a history of heart attack, those taking 200 mg of CoQ10 daily for 12 weeks experienced improvements in blood pressure and serum HDL (“good”) cholesterol, as well as lower LDL (“bad”) cholesterol levels, thereby decreasing the risk of a subsequent heart ...
Answer: Yes, it is possible that CoQ10 is making it harder for you to fall asleep. Fortunately, there are ways to minimize this effect. Learn more in the Concerns and Cautions section of the CoQ10 and Ubiquinol Supplements Review.
These results show that oral administration of coenzyme Q10 increases both brain and brain mitochondrial concentrations. They provide further evidence that coenzyme Q10 can exert neuroprotective effects that might be useful in the treatment of neurodegenerative diseases.
Research has shown that CoQ10 can improve experimental arthritis, decreasing joint inflammation and Th17 cell differentiation. The properties of zinc have been studied in clinical trials where there was a decrease of zinc among patients with RA compared to healthy subjects.
In some cases, doses may be gradually increased to 3000 mg per day. For heart failure and fluid build up in the body (congestive heart failure or CHF): 30 mg once daily, or up to 300 mg per day divided into two or three doses for up to 2 years. Also, 2 mg/kg daily for up to one year has been used.
Reduced CoQ10 levels can lead to mitochondrial dysfunction, which can cause muscle pain , or myopathy. CoQ10 supplements may help relieve muscle pain related to statin use. A 2019 randomized controlled trial investigated the effect of CoQ10 on statin-related muscle pain.