You may feel tired and weak. High amounts of vitamin B12 can also cause you to feel like your hands and feet are tingling. Some studies suggest that taking 25 mcg or more per day might increase your risk of bone fractures. Vitamin B12 injections should only be used to treat severe deficiencies.
The most common cause of high B12 in the blood is due to recent ingestion or injection of supplemental vitamin B12.
Alcohol. Research has suggested that the consumption of alcohol may reduce vitamin B12 levels. An older study indicated that moderate alcohol intake diminished vitamin B12 by 5% among “healthy, well-nourished, postmenopausal women.”
What Abnormal Results Mean. Values of less than 160 pg/mL (118 pmol/L) are a possible sign of a vitamin B12 deficiency. People with this deficiency are likely to have or develop symptoms. Older adults with a vitamin B12 level less than 100 pg/mL (74 pmol/L) may also have symptoms.
There is no upper limit for vitamin B-12 intake because consuming high levels does not cause problems. However, having naturally high levels of vitamin B-12 in the body may be a cause for concern, as it suggests a severe underlying condition.
Elevated levels of serum cobalamin may be a sign of a serious, even life-threatening, disease. Hematologic disorders like chronic myelogeneous leukemia, promyelocytic leukemia, polycythemia vera and also the hypereosinophilic syndrome can result in elevated levels of cobalamin.
"As you intake more water you can begin to flush water soluble vitamins and minerals," Dr. Kinney told INSIDER. "Water soluble vitamins, such as the B Vitamins (B1, B2, B3, B6 & B12) & vitamin C, are not stored long term and may be excreted with excess water intake if you're not taking in proper supplementation, too.
People who eat a vegan diet and do not take vitamin B12 supplements or eat foods fortified with vitamin B12, are also at risk. Stores of vitamin B12 in the body can last around 2 to 5 years without being replenished, so it can take a long time for any problems to develop after a dietary change.
The body will typically excrete excess vitamin B-12 that a person gets from the diet or via supplements. The body does not absorb vitamin B-12 supplements very effectively. This means that even if a person takes very high amounts of vitamin B-12, their body still does not absorb a significant amount.
What is the relationship between vitamin B12 and stress? The fact is, high levels of stress can deplete your body of B vitamins, which are essential for the nervous and circulatory systems. It can also reduce the absorption of nutrients in your system from the foods you eat and the supplements you take.
Other studies focusing on specific cancers have shown a strong association between elevated B12 levels and liver cancers (OR 3.3 [95%CI: 1.1–10.4] for hepatocellular carcinomas and OR 4.7 [95%CI: 1.2–17.9] for other liver cancers) [16], a moderate association with prostate cancer (OR 1.1 [95%CI: 1.0–1.2]) [17], and no ...
Elevated Vitamin B12 Levels in Autoimmune Lymphoproliferative Syndrome Attributable to Elevated Haptocorrin in Lymphocytes.
Vitamin B12 plays a critical role in the production of dopamine and serotonin, neurotransmitters that help regulate your mood. When you don't get enough B12 in your diet, or your body doesn't process it correctly, it can lead to mental health symptoms, such as depression, irritability, or anxiety.
There are certain foods that also need a cut-down in case of vitamin B12 deficiency. “Some foods and drinks can interfere with vitamin B complex intake like alcohol, caffeine and processed foods, etc should be avoided completely,” Shah added.
Fast heart rate
A fast heart rate may be a symptom of vitamin B-12 deficiency. The heart may start to beat faster to make up for the reduced number of red blood cells in the body. Anemia puts pressure on the heart to push a higher volume of blood around the body and to do it more quickly.
Around 50% to 98% of vitamin B12 is excreted from the body 48 hours after injection. Research shows that vitamin B12 has a half-life of 6 days in the blood, making it six days before the administered amount gets excreted from your body.
In severe liver disease, liver tissue B12 binding and storage by TC is disrupted and causes B12 to leak out of the liver into the circulation. Eventually liver disease could produce enough severe tissue B12 deficits to cause metabolic dysfunction despite elevated plasma total B12.
Deficiency of Vitamin B12 can result in hematological changes, neurological and psychiatric problems, which can manifest as irritability, changes in personality, depression, and memory loss [9]. It is also known to worsen depression by excitotoxic reactions caused by the accumulation of homocysteine [10].
There are other studies that found coffee drinkers tend to have higher homocysteine levels which is a surrogate marker for b12 (and folate) deficiency. Overall it seems clear that coffee and caffeine increase excretion of B vitamins, including B 12.
Taking certain medications: Certain medications can cause low levels of vitamin B12 in your body, including metformin (a drug used to manage diabetes), proton pump inhibitors (PPIs are used to treat GERD and peptic ulcers), histamine H2 blockers (a medicine used to reduce the amount of acid your stomach makes) and oral ...
A serum vitamin B12 level between 200 pg/mL and 900 pg/mL is considered normal, but a threshold of 300 to 350 pg/mL is recognized as a marker for a desirable status in the elderly. The laboratory diagnosis is usually based on low serum vitamin B12 levels or elevated serum methylmalonic acid and homocysteine levels.
Elevated serum B12 levels may also be associated with a functional deficiency of the vitamin. Functional deficiency has been described despite high B12 concentrations and is due to a failure of cellular uptake or intracellular processing, trafficking or utilization.
Vitamin deficiencies are a common cause of paresthesias. The B vitamins — vitamin B12 and vitamin B6 — are the most common ones. Deficiencies in copper, calcium, and magnesium can also lead to tingling in your hands and feet. Most of the time, correcting the deficiency can help reverse the symptoms.
After exclusion of metformin users, diabetic subjects still had significantly higher serum vitamin B12 levels than NGT and AGT individuals (498±15, 456±6, and 445±8 pmol/L, respectively, P=0.006).