Treatment with fluoxetine was associated with a reversal of high Neuroticism scores and low Extraversion scores in the whole sample and in a subgroup of responders but not in non-responders. Among the FFI personality domains, Agreeableness was a better predictor of treatment outcome than baseline HAMD-17 scores.
People taking Prozac or other anti-depressants may experience personality changes for a range of reasons: The stress of waiting for improvement may worsen their mental state or the anti-depressant may produce symptoms of a different, undiagnosed mental illness.
This medication may improve your mood, sleep, appetite, and energy level and may help restore your interest in daily living. It may decrease fear, anxiety, unwanted thoughts, and the number of panic attacks.
Fluoxetine may cause some teenagers and young adults to be agitated, irritable, or display other abnormal behaviors. It may also cause some people to have suicidal thoughts and tendencies or to become more depressed.
Chronic fluoxetine treatment impairs motivation and reward learning by affecting neuronal plasticity in the central amygdala.
One of the widely-reported side effects of SSRIs is 'blunting', where patients report feeling emotionally dull and no longer finding things as pleasurable as they used to.
Taking fluoxetine may affect your ability to do things that need a lot of focus, like exams. You should talk to your doctor about any future exams if you are starting fluoxetine.
Prozac (fluoxetine) was most commonly linked to aggression, increasing violent behavior 10.9 times.
Long-term side effects
Sexual side effects, such as problems getting an erection or a lower sex drive, have been reported after taking fluoxetine for a long time. In some cases, these can continue even after stopping the medicine.
61%) (Padala et al., Reference Padala, Padala, Majagi, Garner, Dennis and Sullivan2020). Antidepressant-induced apathy was observed in all psychiatric disorders, especially in patients with dementia, and with all the SSRIs administered (citalopram, escitalopram, paroxetine, fluoxetine, sertraline).
As an SSRI, Prozac works by preventing the brain from reabsorbing naturally occurring serotonin. Serotonin is involved in mood regulation. In this way, Prozac helps the brain to maintain enough serotonin so that you have a feeling of well-being, resulting from improved communication between brain cells.
As an SSRI, Prozac helps anxiety by keeping serotonin in your system, helping your mood, energy levels, and more. So while Prozac may, technically calm you, it is more of a long-term medication than one that provides immediate relief.
They may also dial down feelings of happiness and joy. This flattening of feelings, called “emotional blunting" or “reduced affect,” is a potential side effect of antidepressants, especially selective serotonin reuptake inhibitors (SSRIs).
Soon more of my patients said the medication made them feel more confident. Most considered the change unreservedly for the good. Others found it eerie and came off the drug. I wrote about effect, first in essays for colleagues and then in my 1993 book, Listening to Prozac.
Conclusion: Fluoxetine treatment has an antiaggressive effect on impulsive aggressive individuals with DSM-III-R personality disorder.
sexual problems in males; decreased sex drive, inability to get or keep an erection, or delayed or absent ejaculation. sexual problems in females; decreased sex drive, or delayed orgasm or unable to have an orgasm. excessive sweating. headache, confusion, weakness, difficulty concentrating, or memory problems.
Although some people may experience some negative fluoxetine side effects such anxiety, agitation, nausea and drowsiness, most people who take it don't experience serious side effects.
For most people, fluoxetine is safe to take for a long time. A few people may get sexual side effects, such as problems getting an erection or a lower sex drive. In some cases, these can continue even after stopping the medicine. Speak to your doctor if you are worried.
You may have flu-like symptoms including headache, muscle pain, weakness, and tiredness. Mood. You may have extreme anxiety, agitation, panic, suicidal ideation, depression, irritability, anger, mania, or mood swings.
Most antidepressants boost mood and reduce depression symptoms by elevating serotonin levels in the brain. Although this is beneficial for someone who's depressed, for someone who does not have depression, taking antidepressant medication can cause serotonin to build up in the body, resulting in serotonin syndrome.
Postmarketing studies and isolated case reports, however, suggest that fluoxetine may harm memory in some patients. Some selective serotonin-reuptake inhibitors (SSRIs) appear to cause memory loss more frequently than others.
Fluoxetine affects brain structures involved in the regulation of both emotional and cognitive behaviors, including the hippocampus and cerebral cortex [5], [6]. Therefore, besides positively modulating mood, fluoxetine might affect learning and memory.
In ADHD children, Fluoxetine monotherapy has been shown to significantly improve inattentiveness and hyperactivity in noncomorbid groups (Barrickman et al. 1991), as well as in groups with co-morbid bipolar disorder (Quintana et al. 2007).
On antidepressant medication, it is possible that you might experience a sense of feeling numb and less like yourself. Though the symptoms of depression have decreased, there may be a sense that other emotional responses – laughing or crying, for example – are more difficult to experience.
When first starting antidepressants, you may not feel like yourself. Though your depression symptoms might have improved, feelings of extreme sadness can sometimes be replaced by an emotional numbness in which you are neither able to cry nor enjoy a real belly laugh. If you feel this way, you are definitely not alone.