For flea or tick infestations, one treatment with Simparica Trio is effective for up to 5 weeks. Further flea or tick treatment should be continued using a different veterinary medicine with a narrower range of action.
It starts working fast* and goes strong for 35 days. Simparica is FDA-approved to block infections that may cause Lyme disease by killing deer ticks.
For those of us that don't always remember to give our preventatives on day 30, Simparica's effects will last until day 35 without tapering off, providing continuous protection. This allows owners a 5 day margin of error should they forget to give their preventatives on time.
This small, chewable tablet kills fleas and ticks for up to 35 days to help prevent illnesses in your dog and eliminate and prevent home infestations.
SIMPARICA TRIO should be administered year‑round at monthly intervals or started at least one month before fleas become active. To minimize the likelihood of flea re‑infestation, it is important to treat all dogs and cats within a household with a flea control product.
If a dose is missed, give SIMPARICA TRIO immediately and resume monthly dosing. When replacing a monthly heartworm preventive product, SIMPARICA TRIO should be given within one month of the last dose of the former medication.
If you miss a dose of Simparica Trio, give it immediately and resume monthly dosing. Contact your vet if your dog misses a month or more of heartworm prevention—your dog might have become infected with heartworm larvae.
As you can see, both Nexgard and Simparica are extremely good and effective flea and tick treatment and they do not have a major difference between them. But that being said, Simparica does kill an additional tick specie and is relatively faster in eliminating fleas and ticks.
Simparica Trio provides broad protection against some of the biggest threats to dogs including: Adult fleas. Brown Dog Ticks & Paralysis Ticks. Heartworm.
How does Simparica Trio work? Simparica contains three active substances: sarolaner, moxidectin and pyrantel. Sarolaner acts as an 'ectoparasiticide'. This means that it kills parasites present on the skin or in the fur of animals, such as fleas and ticks.
Simparica kills adult fleas so fast they don't get a chance to lay eggs and reproduce. Why can I still see fleas on my dog after giving Simparica? Fleas can live in a variety of areas outside of your home as well as on other dogs that your dog may encounter.
If you're hoping to find a broad-spectrum product that protects against fleas and ticks while it defends against internal parasites, Simparica Trio is the clear winner. However, if your dog is already taking a flea and tick preventative, your vet might suggest concomitant use of Heartgard Plus.
Simparica Trio has not demonstrated efficacy against whipworms or tapeworms in dogs or puppies.
The terminal half-lives were similar after oral and IV dosing for both sarolaner (12 days) and moxidectin (11 days). The primary route of elimination of both sarolaner and moxidectin is biliary excretion with minimal metabolism.
Simparica protects against more varieties of ticks than Bravecto does and also offers a variation that protects against worms. Bravecto is effective for three times longer (12 weeks), while Simparica must be reapplied monthly. Each medication will require a prescription from your vet.
The police dog in question who was given Simparica Trio eventually recovered. It is important to help the animal detox, giving a twice-daily dose of 250-500 mg milk thistle for three to four weeks, plus a few drops of fish oil and a teaspoon of coconut oil daily.
Simparica may cause neurologic signs such as tremors, unsteadiness and/or seizures in dogs with or without a history of neurologic disorders. Simparica has not been evaluated in pregnant, breeding or lactating dogs. The most common adverse reactions in clinical trials were vomiting and diarrhea.
The cumulative deaths reported to April 2021 ranged from a high of 2,627 (24%) for fluralaner (Bravecto®) to 726 (2.8%) for afoxolaner (NexGard®) and 412 (12.7%) for sarolaner (Simparica®).
The main differences between the two are the strength and speed at which the products work, with Simparica killing fleas in little as 3 hours and ticks within 8. Nexgard offers a 4 hour time frame for killing fleas while killing ticks in 24 hours.
Both products are safe for dogs when following directions and have been approved by the FDA to treat and prevent flea and tick infestations. However, unlike Bravecto, Simparica has yet to be approved for use in breeding, pregnant, or lactating dogs.
Killing Fleas: Simparica
From the moment your dog ingests Simparica Trio, any fleas they may unknowingly be harboring will be killed in four hours. As for Simparica, any adult fleas who thought they had more time to tie up loose ends will be killed in three hours.
Simparica may cause neurologic signs such as tremors, unsteadiness and/or seizures in dogs with or without a history of neurologic disorders.
If you forget a month of preventative, make sure to give the next 2 doses on time to "catch up" for that missed month. If you miss several months in a row, you should give your vet a call for advice on when to plan for the next heartworm test and how to get started back on preventatives.
You can give it at any time of the day and you can give it with or without food. After you give your dog his Simparica chew the ingredient sarolaner travels in your dog's blood and quickly reaches tissue fluids just under your dog's skin.
That same information showed 720 reported seizures for Bravecto in four years and 557 for Simparica in three years. For Credelio, six seizures were reported in the first six months after its approval.