Leukaemias are grouped in two ways: the type of white blood cell affected - lymphoid or myeloid; and how quickly the disease develops and gets worse. Acute leukaemia appears suddenly and grows quickly while chronic leukaemia appears gradually and develops slowly over months to years.
Acute leukemia may cause signs and symptoms that are similar to the flu. They come on suddenly within days or weeks. Chronic leukemia often causes only a few symptoms or none at all. Signs and symptoms usually develop gradually.
Leukemia occurs when the bone marrow makes abnormal blood cells, usually white blood cells, which do not function as they should. The abnormal cells survive longer, build up in large numbers, and enter the bloodstream.
In CLL, the leukemia cells grow out of control and crowd out normal blood cells. These cells often build up slowly over time. Many people don't have any symptoms for at least a few years. In time, the cells can spread to other parts of the body, including the lymph nodes, liver, and spleen.
Stage 1 – A patient has high levels of white blood cells and enlarged lymph nodes. Stage 2 – A patient has high levels of white blood cells and is anemic. He or she may also have enlarged lymph nodes. Stage 3 – A patient has high levels of white blood cells and is anemic.
Early indicators of acute leukemia can be difficult to recognize because they often mimic the symptoms of influenza and other less serious conditions. Furthermore, with chronic myeloid or lymphocytic leukemia, the abnormal leukemia cells can function almost as well as normal white blood cells.
Some signs of leukemia, like night sweats, fever, fatigue and achiness, resemble flu-like symptoms. Unlike symptoms of the flu, which generally subside as patients get better, leukemia symptoms generally last longer than two weeks, and may include sudden weight loss, bone and joint pain and easy bleeding or bruising.
6. Is leukemia curable if caught early? If caught early, leukemia can be cured by undergoing several cancer treatments.
Your doctor will conduct a complete blood count (CBC) to determine if you have leukemia. This test may reveal if you have leukemic cells. Abnormal levels of white blood cells and abnormally low red blood cell or platelet counts can also indicate leukemia.
Age – Generally speaking, individuals over the age of 65 are more at risk for leukemia. Demographics – While anyone can conceivably develop leukemia, white males are statistically most susceptible.
The median age of a patient diagnosed with acute myeloid leukemia (AML), chronic lymphocytic leukemia (CLL) or chronic myeloid leukemia (CML) is 65 years and older. However, most cases of acute lymphocytic leukemia (ALL) occur in people under 20 years old. The median age of an ALL patient at diagnosis is 15.
How is leukemia diagnosed? A diagnosis of leukemia is usually made by analyzing a patient's blood sample through a complete blood count (CBC) or microscopic evaluation of the blood, or by using flow cytometry.
ALL usually develops quickly over days or weeks. It is the most common type of leukaemia to affect children but can also affect adults.
In the United States, overall, 5-year survival among people diagnosed with leukemia is 65%. However, these statistics vary greatly according to the specific subtype of disease: Chronic lymphocytic leukemia (CLL) 5-year survival rate is 88%. Acute lymphocytic leukemia (ALL) 5-year survival rate is 71.3%.
People in stages 0 to II may live for 5 to 20 years without treatment. CLL has a very high incidence rate in people older than 60 years. CLL affects men more than women. If the disease has affected the B cells, the person's life expectancy can range from 10 to 20 years.
Chronic leukemia usually gets worse slowly, over months to years, while acute leukemia develops quickly and progresses over days to weeks.
During the progression of leukemia, white blood cells (neoplastic leukocytes) found in bone marrow may begin to filter into the layers of the skin, resulting in skin lesions. “It looks like red-brown to purple firm bumps or nodules and represents the leukemia cells depositing in the skin,” Forrestel says.
Slower growing leukaemias such as chronic lymphocytic leukaemia (CLL) and chronic myeloid leukaemia (CML) may cause no symptoms in the early stages. They may be discovered by chance after a routine blood test. If you do have symptoms, these may be mild and develop gradually.
Bone marrow test.
The bone marrow is removed using a long, thin needle. The sample is sent to a laboratory to look for leukemia cells. Specialized tests of your leukemia cells may reveal certain characteristics that are used to determine your treatment options.
Leukemia is a serious condition that requires diagnosis and treatment from a healthcare professional. There are currently no at-home tests that a person may use to aid leukemia diagnosis. If an individual has concerns about their health, they should contact a doctor as soon as possible.