Our study concludes that both 5 mg and 10 mg of rosuvastatin exhibit the antihyperlipidemic effect. The patients treated with 10 mg rosuvastatin showed more reduction in lipid levels and reported more side effects.
In addition, rosuvastatin 5 mg effectively lowers triglycerides (-16%), total cholesterol (-30%), non-high-density lipoprotein cholesterol (non-HDL-C; -38%) and apolipoprotein (apo) B levels (-33%) and increases HDL-C (+8.2-13%) in a wide range of patients with hypercholesterolaemia, including the elderly, obese ...
If you have very high cholesterol and are at high risk of heart attacks or strokes, a specialist may prescribe 40mg a day. This dose is not suitable for everyone. high cholesterol – 5mg to 10mg, taken once a day. Your doctor may increase your dose every 4 weeks up to 20mg a day.
Many people using this medication do not have serious side effects. A very small number of people taking rosuvastatin may have mild memory problems or confusion. If these rare effects occur, talk to your doctor. Rarely, statins may cause or worsen diabetes.
Our study reported that both 5 mg and 10 mg rosuvastatin significantly decreases blood cholesterol, triglycerides, and LDL levels.
Avoid eating foods high in fat or cholesterol, or rosuvastatin will not be as effective. Avoid drinking alcohol. It can raise triglyceride levels and may increase your risk of liver damage. Some antacids can make it harder for your body to absorb rosuvastatin.
Weight gain and weight loss are not known side effects of rosuvastatin. People taking the drug in clinical trials did not report weight changes. Sometimes, your doctor may recommend taking rosuvastatin along with changes in diet, such as limiting saturated fat.
Background: Statins are generally well tolerated, but some patients discontinue therapy secondary to adverse effects. Dosing a statin (rosuvastatin) every other day (EOD) may provide significant lipoprotein changes while avoiding common adverse effects in this statin-intolerant population.
The bottom line
The usual rosuvastatin dosage ranges from 5 mg to 40 mg by mouth once daily. Your specific rosuvastatin dosage may depend on your age, why you're taking it, and your medical history. You can take rosuvastatin with or without food, at any time of day.
Rosuvastatin starts to work within a week to reduce cholesterol, but it can take up to a month to achieve its full effect.
Certain statins work better when taken with a meal. Others work best when they're taken at night. This is because the cholesterol-making enzyme is more active at night. Also, the half-life, or the amount of time it takes for half the dose to leave your body, of some statins is short.
Rosuvastatin is also associated with frank, clinically apparent hepatic injury but this is rare, occurring in less than 1:10,000 patients. The onset is typically after 2 to 4 months ,and the pattern of serum enzyme elevations is usually hepatocellular, although cholestatic cases have also been reported.
Recommended Dosage in Adult Patients
The dosage range for CRESTOR is 5 to 40 mg orally once daily. The recommended dose of CRESTOR depends on a patient's indication for usage, LDL-C, and individual risk for cardiovascular events.
The elimination half-life (t1/2) of rosuvastatin is approximately 19 hours. After an intravenous dose, approximately 28% of total body clearance was via the renal route, and 72% by the hepatic route.
It's important to know that stopping statins cold turkey, or even gradually, can cause serious health problems and you should talk to your doctor before doing so.
If you miss a dose, take it as soon as you can. If your next dose is to be taken in less than 12 hours, then do not take the missed dose. Take the next dose at your regular time. Do not take double or extra doses.
If you quit cold turkey, your body can go into shock. It is not recommended that you stop statins suddenly if you have a history of heart attack or stroke, as it can put you at a higher risk of recurrent heart attack. You should speak with your doctor before stopping the medicine under any circumstance.
Will I have hair loss from rosuvastatin? It's very unlikely. Hair loss isn't a known side effect of taking rosuvastatin. However, hair loss is a side effect of another cholesterol-lowering drug called pravastatin.
These statins, including atorvastatin (Lipitor®), simvastatin (Zocor®) and fluvastatin (Lescol®), are more likely to cause muscle aches. The hydrophilic statins, including rosuvastatin (Crestor®) and pravastatin (Pravachol®), have to be actively transported and cause fewer muscle aches.
Interactions between your drugs
No interactions were found between rosuvastatin and Vitamin D3. However, this does not necessarily mean no interactions exist. Always consult your healthcare provider.
Niacin (Niacor) is a B vitamin — also known as vitamin B3 — that's sometimes taken to help lower cholesterol. However, it can interact with rosuvastatin. This is especially true if you're taking more than 1,000 mg of niacin daily. Taking these medications together can raise your risk of muscle pain or weakness.
If you need to take an antacid that contains aluminum and magnesium (eg, Maalox®), take the antacid at least 2 hours after using rosuvastatin. Do not drink large amounts of alcohol while using rosuvastatin. This could cause side effects on the liver.