Interstitial cystitis (IC) is an autoimmune related condition that causes discomfort or pain in the bladder and a need to urinate frequently and urgently. It is far more common in women than in men. The symptoms vary from person to person. Some people may have pain without urgency or frequency.
If you have Sjogren's syndrome, you are also more likely to have a condition called painful bladder syndrome, or interstitial cystitis. This condition causes signs and symptoms similar to those of a urinary tract infection — urinary frequency, urgency and pain — without evidence of infection.
Interstitial cystitis (in-tur-STISH-ul sis-TIE-tis) is a chronic condition causing bladder pressure, bladder pain and sometimes pelvic pain. The pain ranges from mild discomfort to severe pain. The condition is a part of a spectrum of diseases known as painful bladder syndrome.
Interstitial cystitis/bladder pain syndrome (IC/BPS) is a chronic inflammatory disease characterized by recurrent pain, discomfort, or tenderness in the urinary bladder and pelvic region and can be accompanied by various urinary symptoms, such as urinary frequency, persistent urge to void, and nocturia.
In 2002 the Social Security's Policy Interpretation Ruling on interstitial cystitis/bladder pain syndrome (IC/BPS), recognized IC/BPS as a condition that can be a basis for a disability finding, and it guides the agency's evaluation of IC claims.
What is the outlook for interstitial cystitis? IC is a chronic disease. Patients may find some comfort in the fact that it is not life-threatening and it does not lead to cancer. However, because the symptoms are always present, patients need to develop coping skills to deal with them.
One of the greatest challenges to diagnosing IC/BPS is the significant overlap in symptoms between IC/BPS and other conditions such as urinary tract infection, vulvodynia and endometriosis in women, and chronic prostatitis and chronic orchialgia in men.
The cause of interstitial cystitis (IC) is unknown. Researchers are looking at many theories to understand the causes of IC and find the best treatments. Most people with IC find that certain foods make their symptoms worse.
Dimethylsulfoxide — Dimethylsulfoxide (DMSO) is a liquid medication that has been approved by the US Food and Drug Administration (FDA) to treat interstitial cystitis/bladder pain syndrome (IC/BPS). DMSO is put into the bladder through a temporary catheter and is held in place for approximately 20 minutes, if possible.
Most patients need to continue treatment indefinitely or the symptoms return. Some patients have flare-ups of symptoms even while on treatment. In some patients the symptoms gradually improve and even disappear. Some patients do not respond to any IC/BPS therapy.
However, some people with IC find that certain foods or drinks trigger or worsen their symptoms. Coffee, soda, alcohol, tomatoes, hot and spicy foods, chocolate, caffeinated beverages, citrus juices and drinks, MSG, and high-acid foods can trigger IC symptoms or make them worse.
Patients with IC often avoid Vitamin C as it tends to flare symptoms. More sensitive patients avoid multivitamins as it is difficult to find one without vitamin C. Those patients who have their IC more under control can tolerate some specially buffered Vitamin C and benefit from the IC Multi.
In some people, however, certain antidepressants link, sinus medicines, and pain relievers may trigger symptom flares. Talk with your health care professional if these medicines make your IC worse. Long-term use of pain medicines can be dangerous.
Antihistamines such as hydroxyzine (Atarax, Vistaril) interfere with the mast cells' release of histamine, helping to relieve bladder inflammation and pain, urinary frequency, and nighttime voiding.
Though the most widely used antihistamine to treat IC/BPS is hydroxyzine, some people with IC/BPS find relieve from Claritin, Benadryl, and Singulair.
When other treatments have failed to provide adequate relief, doctors may recommend surgery. Surgical treatment of interstitial cystitis includes the removal of ulcers in the bladder and removal (and replacement) of part of the bladder.
Stress does not cause IC, but if you have IC, stress can cause a flare. Physical stress and mental stress can lead to flares. Remember, every flare will settle down and worrying about it only prolongs the discomfort. Understanding stress and how to minimize it is the best way to limit the intensity of your flares.
Interstitial Cystitis Facts
90% of patients with IC are women, and the average age of onset is 40. Interstitial cystitis is not contagious. It does not spread in the body and does not seem to worsen with time. It is not a cause of bladder cancer.
Recently, diffusion-weighted MRI (DW-MRI) or DWI has been used for the diagnosis of IC/BPS, where a high DW-MRI signal was found to be substantially higher in IC patients compared to normal controls [50,51]. They suggested that having a positive DW-MRI signal was suggestive of IC [50].
People with interstitial cystitis (IC) have repeat discomfort, pressure, tenderness or pain in the bladder, lower abdomen, and pelvic area. Symptoms vary from person to person, may be mild or severe, and can even change in each person as time goes on.
There is no definitive test to make the diagnosis of IC. It is a diagnosis of exclusion. Evaluation usually involves a detailed history, review of old medical records/ urine culture results, physical exam, urine tests, and voiding diary. Abdominal/pelvic imaging studies such as ultrasound or CT may be used.