You can take it at any time, but it's best to take it at the same time every day. Rosuvastatin will not usually upset your stomach, so you can take it with or without food.
So, why do people take statins at night? Many statins work more effectively when they are taken at night. This is because the enzyme which makes the cholesterol is more active at night. Also, the half-life, or the amount of time it takes for half the dose to leave your body, of some statins is short.
A systematic review found that short-acting statins worked best when people took them in the evening. The people who took these statins toward the end of the day had lower total cholesterol and LDL cholesterol levels compared with the people who took them in the morning.
Avoid eating foods high in fat or cholesterol, or rosuvastatin will not be as effective. Avoid drinking alcohol. It can raise triglyceride levels and may increase your risk of liver damage. Some antacids can make it harder for your body to absorb rosuvastatin.
The most common side effects may include:
Headache, muscle aches and pains, abdominal pain, weakness, and nausea. Additional side effects that have been reported with CRESTOR include memory loss and confusion. Tell your doctor if you have any side effect that bothers you or that does not go away.
However, many doctors do hear complaints of insomnia and sleep disturbance from patients taking statins. The best explanation is the 'nocebo' effect – the opposite of the placebo effect.
Background: Adenosine receptor activation is essential for mediating the IS-limiting effects of statins. Caffeine is a nonspecific adenosine receptor blocker, and thus drinking CC may block the myocardial protective effects of statins.
How long does rosuvastatin take to work? Rosuvastatin starts to work within a week to reduce cholesterol, but it can take up to a month to achieve its full effect. Your cholesterol levels should drop within 4 weeks if you take your medicine regularly, as prescribed.
The top-selling statins are atorvastatin (Lipitor), lovastatin (Mevacor), rosuvastatin (Crestor) and simvastatin (Zocor). How they can cause insomnia: The most common side effect of all types of statins is muscle pain, which can keep people who take them awake at night and unable to rest.
Weight gain and weight loss are not known side effects of rosuvastatin. People taking the drug in clinical trials did not report weight changes. Sometimes, your doctor may recommend taking rosuvastatin along with changes in diet, such as limiting saturated fat.
As you are aware, on March 4th of this year, we petitioned the FDA to ban the recently-marketed cholesterol-lowering drug rosuvastatin (Crestor/AstraZeneca) because of seven post-marketing cases of life-threatening rhabdomyolysis and nine cases of renal failure or renal insufficiency, both of which problems had also ...
After a single oral dose the peak plasma concentration is reached at 5 hours. This is longer than other HMG-CoA inhibitors which achieve maximum plasma concentrations in less than 3 hours.
We often tell patients to take statins in the evening because most cholesterol is produced at night. But this isn't always necessary. Lipitor, Crestor, and Pravachol can be taken at ANY time of the day.
If you've made lifestyle changes through diet and exercise that have lowered your cholesterol levels, you may not need to continue taking a statin. These changes can help reduce your risk of heart attack, stroke, or blocked arteries while allowing you to take one less medication.
Grapefruit juice can affect some statins and increase your risk of side effects. A doctor may advise you to avoid it completely or only consume small quantities. The doctor will also ask you how much alcohol you drink before prescribing statins.
Grapefruit juice is the only food or drink that has a direct interaction with statins. Statins do not directly interact with any food but people taking statins should moderate their intake of saturated fats to help lower their LDL cholesterol and overall risk of cardiovascular disease.
While coffee does not contain cholesterol, it can affect cholesterol levels. The diterpenes in coffee suppress the body's production of substances involved in cholesterol breakdown, causing cholesterol to increase. Specifically, coffee diterpenes may cause an increase in total cholesterol and LDL levels.
Other statins don't last as long in your body. If you take them in the morning, they may not be as effective in the evening. So it's recommended to take these statins in the evening: Fluvastatin (IR capsules)
5. The cholesterol-lowering action of alternate-day statins is as effective as daily dosing in many individuals.
Statin use is associated with increased calorie intake and consequent weight gain. It is speculated that statin‐dependent improvements in lipid profile may undermine the perceived need to follow lipid‐lowering and other dietary recommendations leading consequently to increased calorie intake.
The use of statins may be connected to weight gain, but there's no clinical evidence as to why this weight gain occurs.
Muscle and Kidney Damage
The most common side effects for statin patients affect the muscles. Myalgia is the most common of the muscle-related side effects. The risk increases in patients 65 years and older. Patients with kidney impairment are also at an increased risk for myalgia.
Some statins, like rosuvastatin (Crestor), can lower your cholesterol levels more than other statins (if you compare them milligram to milligram). For example, rosuvastatin (Crestor) is considered a moderate-to-high intensity statin.