Should You Take Vitamin B12 At Night? Ideally, no. While there is no scientific evidence recommending against taking B12 at night, because of its role in energy production, it can elicit a stimulatory effect in some people, as do the other B vitamins.
According to health experts at Click Pharmacy, as a general rule of thumb, take your B vitamins in the morning or with a meal. Vitamin B12, for example, should definitely be taken in the morning. This is because it is important for energy metabolism, which may interrupt your sleep if taken at night.
As our metabolism is boosted by B vitamins, this can have a stimulating effect and cause sleep problems if taken late at night.
No interactions were found between Vitamin B12 and Vitamin D3. However, this does not necessarily mean no interactions exist. Always consult your healthcare provider.
Taking vitamin B-12 with vitamin C might reduce the available amount of vitamin B-12 in your body. To avoid this interaction, take vitamin C two or more hours after taking a vitamin B-12 supplement.
Anticonvulsants. The anticonvulsants phenobarbital and phenytoin (Dilantin, Phenytek) increase the breakdown of vitamin D and reduce calcium absorption. Atorvastatin (Lipitor). Taking vitamin D might affect the way your body processes this cholesterol drug.
Final Thoughts. Although there are no guidelines suggesting the recommended time to take vitamin B12, and there is no clinical evidence showing a link between B12 supplementation at night and sleep disruption, it does have the potential to disrupt sleep.
tl;dr. There's no set time of day that's best to take vitamin D supplements. Some people say taking vitamin D supplements at night is an insomnia risk. There's no research to confirm this, but you might want to take your supplement earlier in the day if you think it's screwing with your sleep.
While Vitamin D can be taken at any time of day, taking your supplement at the same time daily may help you develop a consistent habit of taking it. For some people, this means taking it with their breakfast in the morning, after brushing their teeth, or in the evening before bed.
Our only hard recommendation: Avoid supplementing with vitamin D at night. There's evidence that vitamin D can suppress melatonin—which is bad news for your sleep quality.
Due to its special role, vitamin B12 aids in the prevention of anemia, which mostly leads to fatigue. Even though the research available about the relationship between vitamin B12 and insomnia remains unclear, some studies² show that elevated levels of vitamin B12 do cause sleeplessness.
The association of vitamin B12 (VitB12) with sleep patterns is also not definitive. Some researchers found that VitB12 supplementation is associated with a decrease in sleep duration [15, 21, 22], whereas others found no significant association between VitB12 and sleep duration [23].
Once you begin treating your vitamin B12 deficiency, it can take up to six to 12 months to fully recover. It is also common to not experience any improvement during the first few months of treatment. If you can, it's a good idea to address what's causing the deficiency.
B vitamins are vital for supporting brain function, energy levels and cell metabolism as well as help the body produce melatonin. Research has shown that maintaining sufficient levels of Vitamins B3, B5, B6, B9 and B12 may help achieve good sleep.
You can eat and drink as normal while taking cyanocobalamin. However, it's best to take cyanocobalamin on an empty stomach, at least 30 minutes before meals or 2 hours after eating.
According to the National Institutes of Health, vitamin D promotes calcium absorption in the gut and helps regulate the concentration of calcium and phosphorus in the blood, which supports building and maintaining healthy, strong bones and helps regulate skeletal and neuromuscular function.
B12 also plays a role in the production of melatonin, a hormone that helps regulate our circadian rhythms.
It's best to take vitamin B12 in the morning away from food to maximize absorption, as certain nutrients can inhibit it. However, vitamin B12 can be taken with food. Just ensure you're not dealing with any nutrient interactions.
Vitamin B12 is water-soluble, which means you can take it with or without food. (Water-soluble vitamins don't require fat content to aid absorption.) If you have a sensitive stomach, however, we do recommend taking supplements with food.
Ultimately both vitamin D2 and D3 get converted through enzymatic reactions in the liver and kidneys to the active form of vitamin D and can be taken together [1]. So, in simple terms, the answer is YES! You can take vitamin D and D3 together.
The best time to take fat-soluble vitamins like vitamin D, A, and K is with a meal containing fats. You should take water-soluble vitamins like vitamin C, B12, and B6 in the morning on an empty stomach. Take multivitamins or prenatal vitamins with a meal or snack containing fat and a glass of water.
Can you take vitamin D and magnesium together? Yes. In fact, it's probably best to take both together. Because so many people have low magnesium levels, vitamin D supplements on their own aren't very helpful for a large portion of the population.
Other medications can also interfere with your uptake of vitamin B12, possibly raising your risk for deficiency. These medications include antacids and peptic ulcer medications, cholesterol-lowering drugs, antiseizure medications, chemotherapy medications, the diabetes treatment glucophage (Metformin) and others.