Decades of research has proven that statins and other lipid-lowering therapies are very effective in reducing the risk for major vascular events, such as death from cardiovascular causes, heart attack, stroke, or needing a coronary stent or bypass surgery.
Everyone with high cholesterol should start with heart-healthy lifestyle changes like diet, exercise, quitting smoking, and weight loss. But if your cardiac risk is high, you may need treatment with medications, too.
Statins are effective, accessible, and affordable. However, well-known side effects like muscle pain keep some people from taking them.
Your health care team may prescribe medicine if: You have already had a heart attack or stroke or have peripheral arterial disease. Your LDL cholesterol level is 190 mg/dL or higher. You are 40–75 years old and have diabetes and an LDL cholesterol level of 70 mg/dL or higher.
Statins are effective at lowering cholesterol and protecting against a heart attack and stroke, although they may lead to side effects for some people. Health care professionals often prescribe statins for people with high cholesterol.
It's important to know that stopping statins cold turkey, or even gradually, can cause serious health problems and you should talk to your doctor before doing so.
Statin use has been linked to a higher risk of developing diabetes because the medication can fuel mild glucose elevations in predisposed individuals — an effect that can often be countervailed by exercise and losing as little as a few pounds.
High cholesterol levels are considered: too high: between 5 and 6.4mmol/l. very high: between 6.5 and 7.8mmol/l. extremely high: above 7.8mmol/l.
Statins can stabilize cholesterol plaque already attached to artery walls, making it less likely to get worse or rupture, causing a heart attack or stroke. "Statins also help remove cholesterol from you blood by causing the liver to express more LDL cholesterol receptors that take cholesterol out of your blood," Dr.
Statin use is associated with increased calorie intake and consequent weight gain. It is speculated that statin‐dependent improvements in lipid profile may undermine the perceived need to follow lipid‐lowering and other dietary recommendations leading consequently to increased calorie intake.
Early on, plaque build-up can be controlled by healthy lifestyle choices, such as switching to a heart-healthy diet, exercising and not smoking. If those efforts are unsuccessful over time, doctors will introduce treatment with statins to benefit the arteries and prevent further damage.
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There is no reason to be afraid of taking statins if you are at high risk for heart attack or stroke.
You usually have to continue taking statins for life because if you stop taking them, your cholesterol will return to a high level. If you forget to take your dose, do not take an extra one to make up for it.
Statins work to lower cholesterol levels and can reduce the risk of heart disease, heart attack, stroke, and even cardiovascular disease deaths by 25% or more. It's important to note that if you stop taking them, these improved effects on your cholesterol will taper off after several months.
Statins should be taken with caution if you're at an increased risk of developing a rare side effect called myopathy, which is where the tissues of your muscles become damaged and painful. Severe myopathy (rhabdomyolysis) can lead to kidney damage. Things that can increase this risk include: being over 70 years old.
Bempedoic Acid: A Statin Alternative to Reduce Cholesterol
Bempedoic acid is sold under the brand name Nexletol on its own and as a combination drug with ezetimibe called Nexlizet.
Low-density lipoprotein (LDL) is the "bad cholesterol" in terms of its potential for harming the heart and brain. It is a major contributor to arterial plaque development. Levels of LDL cholesterol higher than 130 milligrams per deciliter (mg/dL) are linked to an increased risk for ischemic stroke.
LDL -cholesterol levels greater than 3.5 mmol/L are considered elevated for some people at low cardiovascular risk and most individuals at intermediate risk and may need behavior modifications and/or pharmacological treatment Note 5 (see About cholesterol).
Total cholesterol levels should be lower than 5.5 mmol/L, if you have no other risk factors. If you have cardiovascular risk factors such as high blood pressure, pre-existing cardiovascular (heart) disease or diabetes, or you smoke, the aim for LDL cholesterol levels would be less than 2 mmol/L.
A new study in JAMA Network Open, found that roughly 20% of high-risk patients don't take statins, even when their doctor recommends them. Statins are a group of cholesterol-lowering medications, taken as a daily pill, that have been shown to protect against heart attacks and strokes.
Fear of side effects and perceived side effects are the most common reasons for declining or discontinuing statin therapy. Willingness to take a statin is high, among both patients who have declined statin therapy and those who have never been offered one.