Generally, the Simparica Trio medication is well-tolerated amongst dogs. Side effects are uncommon but can include vomiting, diarrhea, lethargy, loss of appetite, increased thirst and itching or skin irritation.
Simparica for dogs is a drug from the isoxazoline class. This class has been linked to neurological signs such as tremors, unsteadiness, and seizures in dogs. However, the FDA considers drugs in the isoxazoline class to be safe and effective for dogs.
Simparica Trio should be used with caution in dogs with a history of seizures. This is because drugs in the isoxazoline class have been associated with neurologic reactions including seizures, tremors, and ataxia in dogs with or without a history of neurologic disorders.
The cumulative deaths reported to April 2021 ranged from a high of 2,627 (24%) for fluralaner (Bravecto®) to 726 (2.8%) for afoxolaner (NexGard®) and 412 (12.7%) for sarolaner (Simparica®).
But that being said, Simparica does kill an additional tick specie and is relatively faster in eliminating fleas and ticks. Hence, Simparica would be the bigger bet, but Nexgard is just as effective. So before you opt for any oral treatment, consult your vet first.
Both products are safe for dogs when following directions and have been approved by the FDA to treat and prevent flea and tick infestations. While Simparica was trialed and not approved, Nexgard has not yet been evaluated for use in breeding, pregnant, or lactating dogs.
Final Thoughts on Bravecto vs Simparica
Bravecto costs just a little bit more than Simparica but is worth every penny if you value the convenience factor of administering only once every 12 weeks. It's also worth considering that Bravecto will kill any new fleas since administering it.
Side Effects & Warnings
Simparica is for use only in dogs, 6 months of age and older. Simparica may cause abnormal neurologic signs such as tremors, unsteadiness, and/or seizures.
Additionally, the chemicals in some flea treatments can be irritating to dogs, leading to discomfort and restlessness. Finally, some dogs may experience an allergic reaction to the ingredients in flea medicine, which can also lead to restlessness.
That same information showed 720 reported seizures for Bravecto in four years and 557 for Simparica in three years. For Credelio, six seizures were reported in the first six months after its approval. The manufacturers said the risk of side effects is rare, less than one in 10,000 doses sold.
Adverse reactions in dogs treated with SIMPARICA TRIO included diarrhea and vomiting. For a copy of the Safety Data Sheet or to report adverse reactions, call Zoetis Inc. at 1‑888‑963‑8471.
The police dog in question who was given Simparica Trio eventually recovered. It is important to help the animal detox, giving a twice-daily dose of 250-500 mg milk thistle for three to four weeks, plus a few drops of fish oil and a teaspoon of coconut oil daily.
Bravecto Chew is also effective in killing adult fleas, so it can help reduce the risk of your dog getting flea bite dermatitis. If you're looking for a safe and effective flea and tick treatment for your dog, Bravecto Chew is the way to go.
Simparica Trio contains sarolaner, a member of the isoxazoline class, which has been associated with neurologic adverse reactions including tremors, ataxia, and seizures in dogs with or without a history of neurologic disorders.
Use with caution in dogs with a history of seizures or neurologic disorders. Prior to administration of SIMPARICA TRIO, dogs should be tested for existing heartworm infections. Infected dogs should be treated with an adulticide to remove adult heartworms.
I have read that Simparica may cause side effects including muscle tremors, diarrhea, lethargy, anorexia, otitis externa, hyperactivity, neurological side effects, seizures, convulsions, anxiety and skin irritation.
Heartworm Prevention: SIMPARICA TRIO should be administered at monthly intervals year‑round or at least within one month of the animal's first seasonal exposure to mosquitoes and continuing until at least 1 month after the dog's last seasonal exposure.
Simparica is a monthly chewable that protects your dog for 35 days. That means you have a little wiggle room at the end of the month. If you have questions about dosing, talk to your vet.
This small, chewable tablet kills fleas and ticks for up to 35 days to help prevent illnesses in your dog and eliminate and prevent home infestations.
Seizures in dogs are common, but it does appear that the risk increases when using Nexgard, Bravecto and Simparica.
Simparica kills both fleas and ticks, while Frontline Plus is effective against fleas, ticks, flea eggs and larvae and lice. Simparica kills fleas within 3 hours and kills ticks within 8 hours. Frontline Plus kills fleas within 12 hours and ticks within 48.
Simparica resides there, waiting to spring into action. This preventative kills fleas within 3 hours and ticks within 8; this is faster than the 12 hour kill time from its competitors. Another convenient feature is the efficacy.
Simparica is an excellent choice for flea and tick protection. The monthly chew also comes with an option for heartworm protection, too, as Simparica Trio. But while Simparica is usually safe flea and tick treatment for dogs, it shouldn't be prescribed to dogs with a history of seizures.
Simparica wipes out ticks all month long with no risky gaps in protection. In well-controlled laboratory studies, Simparica chewable tablets demonstrated ≥96.9% effectiveness for 35 days against Ixodes scapularis, Amblyomma americanum, Amblyomma maculatum, Dermacentor variabilis, and Rhipicephalus sanguineus.