Side effects Simparica for dogs is a drug from the isoxazoline class. This class has been linked to neurological signs such as tremors, unsteadiness, and seizures in dogs. However, the FDA considers drugs in the isoxazoline class to be safe and effective for dogs.
Safe for most dogs: Simparica Trio has been tested and found to be safe for use in most dogs, including those with sensitive stomachs and those with certain medical conditions.
Side Effects & Warnings
Simparica is for use only in dogs, 6 months of age and older. Simparica may cause abnormal neurologic signs such as tremors, unsteadiness, and/or seizures. Simparica has not been evaluated in dogs that are pregnant, breeding or lactating.
As you can see, both Nexgard and Simparica are extremely good and effective flea and tick treatment and they do not have a major difference between them. But that being said, Simparica does kill an additional tick specie and is relatively faster in eliminating fleas and ticks.
That same information showed 720 reported seizures for Bravecto in four years and 557 for Simparica in three years. For Credelio, six seizures were reported in the first six months after its approval. The manufacturers said the risk of side effects is rare, less than one in 10,000 doses sold.
The cumulative deaths reported to April 2021 ranged from a high of 2,627 (24%) for fluralaner (Bravecto®) to 726 (2.8%) for afoxolaner (NexGard®) and 412 (12.7%) for sarolaner (Simparica®).
If you give your dog or cat the flea and tick preventatives Bravecto, Nexgard, Simparica, or Credelio, the FDA wants you to be aware that these medications may cause neurological issues like stumbling, seizures, and twitching in your pet.
Side effects are uncommon, but may occur in some cases. In clinical trials, vomiting and diarrhea were the most frequently reported adverse reactions.
Simparica may cause neurologic signs such as tremors, unsteadiness and/or seizures in dogs with or without a history of neurologic disorders.
Simparica is an excellent choice for flea and tick protection. The monthly chew also comes with an option for heartworm protection, too, as Simparica Trio. But while Simparica is usually safe flea and tick treatment for dogs, it shouldn't be prescribed to dogs with a history of seizures.
Simparica is a chewable treatment for fleas, ticks and mites. You simply give one chew every 5 weeks to keep your dog protected.
Sarolaner, one of the ingredients in SIMPARICA TRIO, is a member of the isoxazoline class. This class has been associated with neurologic adverse reactions including tremors, ataxia, and seizures. Seizures have been reported in dogs receiving isoxazoline class drugs, even in dogs without a history of seizures.
This small, chewable tablet kills fleas and ticks for up to 35 days to help prevent illnesses in your dog and eliminate and prevent home infestations.
If chemical products are necessary for additional flea or tick control, NRDC recommends s-methoprene or pyriproxyfen, which are less toxic ingredients—but read the labels carefully because some products use them with other, more harmful pesticides.
I have read that Simparica may cause side effects including muscle tremors, diarrhea, lethargy, anorexia, otitis externa, hyperactivity, neurological side effects, seizures, convulsions, anxiety and skin irritation.
In studies, Simparica was 98.8% effective in killing ticks before the transmission could occur. Protection against infected ticks is important for your canine companion, as well as other family members within the house. Lyme disease is zoonotic meaning it can be transferred between animals and humans.
Sometimes the reactions don't occur until multiple doses of the medication have been given. Other side effects that have been reported include: Liver failure. Kidney failure.
Results: Simparica Trio was generally well tolerated. Emesis occurred at low frequency in all groups including control. Abnormal stool occurred occasionally in the 1× and 3× groups throughout the 3-month study.
Sarolaner, one of the ingredients in SIMPARICA TRIO, is a member of the isoxazoline class. This class has been associated with neurologic adverse reactions including tremors, ataxia, and seizures. Seizures have been reported in dogs receiving isoxazoline class drugs, even in dogs without a history of seizures.
Both products are safe for dogs when following directions and have been approved by the FDA to treat and prevent flea and tick infestations. However, unlike Bravecto, Simparica has yet to be approved for use in breeding, pregnant, or lactating dogs.
The police dog in question who was given Simparica Trio eventually recovered. It is important to help the animal detox, giving a twice-daily dose of 250-500 mg milk thistle for three to four weeks, plus a few drops of fish oil and a teaspoon of coconut oil daily.
Adverse reactions in dogs treated with SIMPARICA TRIO included diarrhea. In a third field safety and effectiveness study, SIMPARICA TRIO was administered to 120 dogs with roundworms. Adverse reactions in dogs treated with SIMPARICA TRIO included diarrhea and vomiting.
Simparica Trio contains sarolaner, a member of the isoxazoline class, which has been associated with neurologic adverse reactions including tremors, ataxia, and seizures in dogs with or without a history of neurologic disorders.
The manufacturers says the risk of side effects is very rare, less than one in 10,000 doses sold. Seizures had been mentioned as a possible side effect of Simparica and the other three drugs, but only in very small print, sometimes on the back of the boxes and in the lengthy product inserts inside the boxes.
Collars such as Seresto will repel fleas and ticks, and even prevent ticks from attaching, but they must be applied tightly enough to have skin contact. Many topical options containing permethrin (e.g. K9 Advantix II, Vectra 3D) will repel and prevent tick attachment.