Generally, the Simparica Trio medication is well-tolerated amongst dogs. Side effects are uncommon but can include vomiting, diarrhea, lethargy, loss of appetite, increased thirst and itching or skin irritation.
Simparica Trio should be used with caution in dogs with a history of seizures. This is because drugs in the isoxazoline class have been associated with neurologic reactions including seizures, tremors, and ataxia in dogs with or without a history of neurologic disorders.
Simparica Trio provides broad protection against some of the biggest threats to dogs including: Adult fleas. Brown Dog Ticks & Paralysis Ticks. Heartworm.
The cumulative deaths reported to April 2021 ranged from a high of 2,627 (24%) for fluralaner (Bravecto®) to 726 (2.8%) for afoxolaner (NexGard®) and 412 (12.7%) for sarolaner (Simparica®).
Simparica for dogs is a drug from the isoxazoline class. This class has been linked to neurological signs such as tremors, unsteadiness, and seizures in dogs. However, the FDA considers drugs in the isoxazoline class to be safe and effective for dogs.
Abnormal neurologic signs such as tremors, decreased conscious proprioception, ataxia, decreased or absent menace, and/or seizures were reported in dogs receiving SIMPARICA (see Animal Safety).
Both products are safe for dogs when following directions and have been approved by the FDA to treat and prevent flea and tick infestations. While Simparica was trialed and not approved, Nexgard has not yet been evaluated for use in breeding, pregnant, or lactating dogs.
But that being said, Simparica does kill an additional tick specie and is relatively faster in eliminating fleas and ticks. Hence, Simparica would be the bigger bet, but Nexgard is just as effective. So before you opt for any oral treatment, consult your vet first.
That same information showed 720 reported seizures for Bravecto in four years and 557 for Simparica in three years. For Credelio, six seizures were reported in the first six months after its approval. The manufacturers said the risk of side effects is rare, less than one in 10,000 doses sold.
Simparica Trio Side Effects
Side effects are uncommon but can include vomiting, diarrhea, lethargy, loss of appetite, increased thirst and itching or skin irritation. If you notice any of these symptoms it is important to contact your veterinarian immediately to prevent any long lasting effects.
Use with caution in dogs with a history of seizures or neurologic disorders. Prior to administration of SIMPARICA TRIO, dogs should be tested for existing heartworm infections. Infected dogs should be treated with an adulticide to remove adult heartworms.
Additionally, the chemicals in some flea treatments can be irritating to dogs, leading to discomfort and restlessness. Finally, some dogs may experience an allergic reaction to the ingredients in flea medicine, which can also lead to restlessness.
I have read that Simparica may cause side effects including muscle tremors, diarrhea, lethargy, anorexia, otitis externa, hyperactivity, neurological side effects, seizures, convulsions, anxiety and skin irritation.
Bravecto Chew is also effective in killing adult fleas, so it can help reduce the risk of your dog getting flea bite dermatitis. If you're looking for a safe and effective flea and tick treatment for your dog, Bravecto Chew is the way to go.
How long does Simparica protection last? Simparica is a monthly chewable that starts protecting in hours* and lasts for 35 days.
Both products are safe for dogs when following directions and have been approved by the FDA to treat and prevent flea and tick infestations. However, unlike Bravecto, Simparica has yet to be approved for use in breeding, pregnant, or lactating dogs.
Choosing between Simparica Trio and Trifexis
For pet parents on the hunt for an effective, safe, and reliable way to protect their pups against heartworms, fleas, hookworms, and roundworms, Trifexis and Simparica Trio are two incredible options.
While Simparica is focused on flea and tick prevention, alternatives like Bravecto, NexGard, and Trifexis offer additional coverage for heartworms and intestinal parasites. It's essential to consider your dog's needs and consult your veterinarian to choose the best option.
felis and C. canis, a single oral dose of Simparica Trio™ reduced live flea counts by ≥ 99.9% within 24 hours of treatment and by 100% within 24 hours of weekly re-infestation for 35 days [17].
Simparica Trio is a veterinary medicine used to treat dogs with flea or tick infestations and roundworm or hookworm infections in the gut. At the same time, Simparica Trio is used to prevent heartworm and lungworm disease (both caused by blood worms that infect the heart and blood vessels supplying the lungs).
Simparica kills both fleas and ticks, while Frontline Plus is effective against fleas, ticks, flea eggs and larvae and lice. Simparica kills fleas within 3 hours and kills ticks within 8 hours. Frontline Plus kills fleas within 12 hours and ticks within 48.
Seizures in dogs are common, but it does appear that the risk increases when using Nexgard, Bravecto and Simparica.
Side effects with Simparica are not common. However, the following side effects are seen in less than 1 dog in 10,000: mild and short-lived vomiting and diarrhoea as well as tremor (shaking), ataxia (inability to coordinate body movements) or convulsions. These signs usually resolve without treatment.
Since these products have obtained their respective FDA approvals, data received by the agency as part of its routine post-marketing activities indicates that some animals receiving Bravecto, Nexgard or Simparica have experienced adverse events such as muscle tremors, ataxia, and seizures.