Conclusions. This study demonstrated that Simparica Trio (sarolaner, pyrantel, moxidectin) was well tolerated when administered to heartworm-positive dogs at 1× and 3× the maximum recommended dose at 28-day intervals for 3 consecutive months.
SIMPARICA TRIO should be administered at monthly intervals year‑round or at least within one month of the animal's first seasonal exposure to mosquitoes and continuing until at least 1 month after the dog's last seasonal exposure.
Simparica Trio should be used with caution in dogs with a history of seizures. This is because drugs in the isoxazoline class have been associated with neurologic reactions including seizures, tremors, and ataxia in dogs with or without a history of neurologic disorders.
Simparica may cause neurologic signs such as tremors, unsteadiness and/or seizures in dogs with or without a history of neurologic disorders. Simparica has not been evaluated in pregnant, breeding or lactating dogs. The most common adverse reactions in clinical trials were vomiting and diarrhea.
Simparica TRIO should be administered at monthly intervals. It can be given year-round or, at minimum, within one month of the dog's first seasonal exposure to mosquitoes and continued until at least one (1) month after the dog's last seasonal exposure to mosquitoes.
Simparica may cause neurologic signs such as tremors, unsteadiness and/or seizures in dogs with or without a history of neurologic disorders.
As you can see, both Nexgard and Simparica are extremely good and effective flea and tick treatment and they do not have a major difference between them. But that being said, Simparica does kill an additional tick specie and is relatively faster in eliminating fleas and ticks.
The cumulative deaths reported to April 2021 ranged from a high of 2,627 (24%) for fluralaner (Bravecto®) to 726 (2.8%) for afoxolaner (NexGard®) and 412 (12.7%) for sarolaner (Simparica®).
Both products are safe for dogs when following directions and have been approved by the FDA to treat and prevent flea and tick infestations. While Simparica was trialed and not approved, Nexgard has not yet been evaluated for use in breeding, pregnant, or lactating dogs.
Results: Simparica Trio was generally well tolerated. Emesis occurred at low frequency in all groups including control. Abnormal stool occurred occasionally in the 1× and 3× groups throughout the 3-month study.
Simparica Trio provides broad protection against some of the biggest threats to dogs including: Adult fleas. Brown Dog Ticks & Paralysis Ticks. Heartworm.
That same information showed 720 reported seizures for Bravecto in four years and 557 for Simparica in three years. For Credelio, six seizures were reported in the first six months after its approval.
Simparica is an excellent choice for flea and tick protection. The monthly chew also comes with an option for heartworm protection, too, as Simparica Trio. But while Simparica is usually safe flea and tick treatment for dogs, it shouldn't be prescribed to dogs with a history of seizures.
The police dog in question who was given Simparica Trio eventually recovered. It is important to help the animal detox, giving a twice-daily dose of 250-500 mg milk thistle for three to four weeks, plus a few drops of fish oil and a teaspoon of coconut oil daily.
Currently, for Simparica, less than 0.01% of dogs taking this medication have experienced any neurologic side effects. The FDA considers this level to be “very rare”. The isoxazoline class of drugs acts at receptors in the central nervous system of invertebrates like fleas and ticks.
I have read that Simparica may cause side effects including muscle tremors, diarrhea, lethargy, anorexia, otitis externa, hyperactivity, neurological side effects, seizures, convulsions, anxiety and skin irritation.
Both products are safe for dogs when following directions and have been approved by the FDA to treat and prevent flea and tick infestations. However, unlike Bravecto, Simparica has yet to be approved for use in breeding, pregnant, or lactating dogs.
If you give your dog or cat the flea and tick preventatives Bravecto, Nexgard, Simparica, or Credelio, the FDA wants you to be aware that these medications may cause neurological issues like stumbling, seizures, and twitching in your pet.
Simparica is safe and effective in the treatment and prevention of flea infestations.
If you have a breeding dog, a pregnant dog, or a puppy between 6 and 8 weeks old, Heartgard Plus is the safest option. If you're hoping to find a broad-spectrum product that protects against fleas and ticks while it defends against internal parasites, Simparica Trio is the clear winner.
How does Simparica Trio work? Simparica contains three active substances: sarolaner, moxidectin and pyrantel. Sarolaner acts as an 'ectoparasiticide'. This means that it kills parasites present on the skin or in the fur of animals, such as fleas and ticks.
Simparica Trio has not demonstrated efficacy against whipworms or tapeworms in dogs or puppies.
Simparica, NexGard, Bravecto & Credelio may not increase the number of seizures, but the risk is real. Whether you use it will depend on how likely it is that your dog will get a tick and your confidence in other methods of prevention.
If your dog does have a history of seizures, it is advised to use different flea and tick medications than those mentioned above. Topical medications such as Advantage, Vectra, Revolution, or Frontline are good choices. Some dogs may have a localized reaction to topical medications.