Zoledronic acid has an average rating of 4.7 out of 10 from a total of 223 reviews for the treatment of Osteoporosis. 32% of reviewers reported a positive experience, while 48% reported a negative experience.
User Reviews for Zoledronic acid for Prevention of Osteoporosis. Zoledronic acid has an average rating of 3.9 out of 10 from a total of 55 reviews for the treatment of Prevention of Osteoporosis. 25% of reviewers reported a positive experience, while 62% reported a negative experience.
Zoledronic acid belongs to a class of drugs known as bisphosphonates. It lowers high blood calcium levels by reducing the amount of calcium released from your bones into your blood. It also works by slowing the breakdown of your bones by cancer to prevent bone fractures.
Zoledronic acid can cause flu-like symptoms such as joint and muscle pain, fatigue, shivering and fever. These can last for a few days. Your treatment team can advise you about taking mild pain relief to help.
EFFECTIVENESS. Zoledronic acid has been shown to decrease spine and hip fractures in two studies. It has been studied in women with a mean age of 73 years who are at high risk of fracture (three-year risk of any fracture of 12.8 percent).
Zoledronate (zoledronic acid) Zoledronate is a drug treatment for osteoporosis. It can help to strengthen bones, making them less likely to break. It is given as an intravenous infusion (IV or 'drip') once a year.
Fosamax is usually the first-choice option for osteoporosis. But Prolia may be preferred in people with very high fracture risk. The most common side effects of Boniva and Fosamax are gastrointestinal symptoms like acid reflux, nausea, and diarrhea.
We have used our recent trial comparing zoledronate and placebo over 6 years in 2000 older osteopenic women to re-examine these questions. Both treatment groups lost body weight during the study (placebo 1.65 kg, zoledronate 1.05 kg), and this was significantly greater in the placebo group (P = 0.01).
May not be suitable for some people including those with kidney disease, pre-existing esophageal or gastrointestinal conditions, low blood calcium levels (hypocalcemia), or dental disease.
Renal deterioration, progression to renal failure and dialysis have been reported in patients after the initial dose or a single dose of 4 mg zoledronic acid.
Zoledronic acid is generally well tolerated. Additional comparative data are required to definitively position zoledronic acid with respect to other agents.
Medicare recipients who are prescribed zoledronic acid as an outpatient treatment, Medicare Part B may cover some of the cost of your care and medication. There may be a copay or coinsurance amount that applies, as well as a deductible amount that must be met before costs are covered by Medicare.
A Link between Poor Dental Health and Risk of Osteonecrosis of the Jaw. Zoledronic acid and similar drugs, known as bisphosphonates, interfere with the breakdown of bone tissue that results when cancer cells grow in the bone.
General Handling: Avoid breathing vapor or mist. Avoid contact with eyes, skin and clothing. Use appropriate personal protective equipment(PPE) while handling (see section 8). Wash hands and any exposed skin after removal of PPE.
Zoledronic acid is associated with a 25% increased risk of atrial fibrillation during its first year of use for osteoporosis compared to treatment with denosumab, shows a US study published in Journal of Bone and Mineral Research.
In addition to its effects on bone cells, ZOL has profound effects on the immune system, including a plethora of immune cell subsets expressing the mevalonate pathway enzymes, leading to a general increase in anti-tumour immunity [65].
Hair loss. Hair loss can occur with Zometa use. Hair loss can also occur with cancer treatments that you may have with Zometa. These treatments include chemotherapy or radiation therapy.
Adverse reactions that have been attributed to zoledronic acid include nausea, fever and itching. Hypocalcaemia will occur in 6% of patients. If this is symptomatic the patient may need to be given calcium gluconate. Renal function should be monitoredas it can be impaired by bisphosphonates.
The majority of the side effects, such as fever and chills, pain in the muscles or joints, and headache, occur within the first three days following the dose of Zoledronic acid 5 mg. The symptoms are usually mild to moderate and go away within three days.
Bisphosphonates. For both men and women at increased risk of fracture, the most widely prescribed osteoporosis medications are bisphosphonates.
Medications and Supplements
And medications alone aren't enough to reverse osteoporosis. Improving your nutrition, exercising, and eliminating unhealthy habits are still necessary to rebuild bone strength even when medication is recommended.