A positive HPV test means you do have an HPV type that may be linked to cervical cancer. This does not mean you have cervical cancer now. But it could be a warning. The specific HPV type may be identified to determine the next step.
A positive test result means that you have a type of high-risk HPV that's linked to cervical cancer. It doesn't mean that you have cervical cancer now, but it's a warning sign that cervical cancer could develop in the future.
If the HPV test is positive, you may need additional follow-up tests. Atypical glandular cells (AGC): Some glandular cells were found that do not look normal. This can be a sign of a more serious problem up inside the uterus, so your healthcare provider will likely ask you to come back for a colposcopy.
If you got a positive HPV test and your Pap test was abnormal, your doctor will probably follow up with a colposcopy. Try to see a physician who specializes in this procedure. During a colposcopy, your doctor will look more closely at the cervix, vagina or vulva with a special microscope called a colposcope.
About 10% of women with HPV infection on their cervix will develop long-lasting HPV infections that put them at risk for cervical cancer. Similarly, when high-risk HPV lingers and infects the cells of the vulva, vagina, penis, or anus, it can cause cell changes called precancers.
Research has found that it can take 10 to 20 years, or even longer, for HPV-infected cervical cells to develop into a cancerous tumor. Among women whose cervical cells are infected with high-risk HPV, several factors increase the chance that the infection will be long lasting and lead to precancerous cervical cells.
HPV can cause cervical and other cancers, including cancer of the vulva, vagina, penis, or anus. It can also cause cancer in the back of the throat (called oropharyngeal cancer). This can include the base of the tongue and tonsils. Cancer often takes years, even decades, to develop after a person gets HPV.
WHAT CAUSES AN ABNORMAL PAP SMEAR RESULT? HPV, Human Papiloma Virus, causes abnormal Pap smear results because HPV is a virus which infects skin cells. When subclinical HPV infects the skin cells in the cervix (skin cells on the cervix are called squamous cells), it causes the cells to change and become abnormal.
The cervix is numbed with local anesthesia. An electrically charged loop made of thin wire is inserted through the speculum and up to the cervix. As the loop is passed across the cervix, it cuts away a thin layer of surface tissue, removing the abnormal cells.
If you have low grade changes but HPV is found on the sample (HPV positive), you will get an invitation for a colposcopy. This test can show whether you need treatment for the abnormal cells. You also have a colposcopy if you have high grade cell changes.
Most abnormal Pap tests are caused by HPV infections. Other types of infection—such as those caused by bacteria, yeast, or protozoa (Trichomonas)—sometimes lead to minor changes on a Pap test called atypical squamous cells.
HPV infections are very common. Nearly everyone will get HPV at some point in their lives. More than 42 million Americans are currently infected with HPV types that cause disease. About 13 million Americans, including teens, become infected each year.
Anyone who has had sex can get HPV, even if it was only with only one person, but infections are more likely in people who have had many sex partners. Even if a person delays sexual activity until marriage, or only has one partner, they are still at risk of HPV infection if their partner has been exposed.
High-risk HPV doesn't have symptoms
Unfortunately, most people who have a high-risk type of HPV will never show any signs of the infection until it's already caused serious health problems. That's why regular checkups are so important — testing is the only way to know for sure if you're at risk for cancer from HPV.
For 90 percent of women with HPV, the condition will clear up on its own within two years. Only a small number of women who have one of the HPV strains that cause cervical cancer will ever actually develop the disease.
HPV causes
The virus that causes HPV infection is transmitted through skin-to-skin contact. Most people get a genital HPV infection through direct sexual contact, including vaginal, anal, and oral sex. Because HPV is a skin-to-skin infection, intercourse isn't required for transmission to occur.
HPV usually doesn't make you feel sick or cause any symptoms. Your immune system can fight off the infection before you ever know you have it, but you could still spread it to others before that happens. If you do get symptoms, the most common signs of HPV are genital warts.
Most people with HPV do not experience symptoms. However, some types of HPV cause warts or bumps on the skin. They may occur in or around the genitals, anus, tongue, mouth, or lips. Sometimes, HPV also causes warts on other areas of skin, such as the hands or feet.
Patients with HPV-unrelated tumors experienced significantly higher levels of fatigue over the course of the study (p=0.0097, Table 2), especially at pre-IMRT (p=0.001) and three-month post-IMRT (p=0.002), compared to those with HPV-related tumors (Figure 1a).
You're contagious for as long as you have the virus — regardless of whether or not you have symptoms. For example, even if your genital warts have disappeared, you can still spread the HPV that caused them if the virus is still in your body. Once your immune system destroys the virus, you're no longer contagious.
Most of the abnormal cells found during a Pap test are the result of a cervical or vaginal infection and are not cancerous. Abnormal Pap tests are very common. In fact, of the 3 million women with abnormal Pap tests each year, less than 1% (13,240 cases) will be diagnosed with cervical cancer.
Around 90% of HPV infections clear within 2 years. For a small number of women and people with a cervix, their immune system will not be able to get rid of HPV. This is called a persistent infection. A persistent HPV infection causes the cells of the cervix to change.
HPV-related cancers often take years to develop after getting an HPV infection. Cervical cancer usually develops over 10 or more years. There can be a long interval between being infected with HPV, the development of abnormal cells on the cervix and the development of cervical cancer.
Almost all cervical cancer is caused by HPV. Some cancers of the vulva, vagina, penis, anus, and oropharynx (back of the throat, including the base of the tongue and tonsils) are also caused by HPV.