“When comparing all antidepressants, bupropion [Wellbutrin] is the least likely to cause weight gain and, in most cases, will be weight neutral or cause weight loss over time. Alternatively, mirtazapine [Remeron] is most widely implicated in weight gain as a side effect.”
Both drugs might cause weight changes. However, the main difference between Zoloft and Prozac is that research suggests weight gain might be more pronounced with Prozac than Zoloft weight gain.
A common side effect is Zoloft weight gain. Not everyone experiences sertraline weight gain. Much of the time, research shows that body weight gain is modest or temporary. That said, it's still important to understand the potential side effect and discuss it with your doctor before starting treatment.
Lexapro weight gain can be a common side effect, but it doesn't impact everyone who takes this medication. Multiple studies conclude that SSRIs like Lexapro can result in weight gain. However, it varies from person to person depending on individual factors such as age, lifestyle habits, diet, and activity level.
Several clinical studies suggest that the longer you take SSRI antidepressants (Lexapro), the more likely you are to gain weight – with some studies reporting that possible weight changes may occur following six months or more of treatment [7, 8, 9].
MD. Zoloft is an SSRI medication that may cause weight gain. The extent to which this occurs can vary depending on the individual and other factors. It is important to focus on maintaining a healthy lifestyle to help manage weight, such as eating a balanced diet and getting regular physical activity.
Put simply, weight gain is a fairly common side effect of both SSRIs and other antidepressants -- not an isolated side effect that only occurs with sertraline.
Which antidepressants are less likely to cause weight gain? Fluoxetine (Prozac) and sertraline (Zoloft and Lustral) are two antidepressants often less likely to cause weight gain.
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These include: Bupropion (Wellbutrin; see Important Safety Information) Fluoxetine (Prozac; see Important Safety Information) Duloxetine (Cymbalta; see Important Safety Information)
Share on Pinterest Antidepressants may lead to weight gain as a person regains their appetite. Experts do not fully understand why antidepressants lead to weight gain in some people. One theory is that both metabolism and hunger levels may be affected.
Antidepressants treat mental health conditions but can affect body weight. Although most can cause weight gain, a few antidepressants, including fluoxetine and duloxetine, may decrease appetite and lead to temporary weight loss.
Most antidepressants list weight gain as a potential side effect of use, however not everyone gains weight when taking antidepressants. “Based on my clinical experience, about a third of people typically gain weight when taking an antidepressant,” says Dr. Andrew Morson, a New Orleans-based psychiatrist.”
That being said, a 2015 study published in General Hospital Psychiatry found that both Lexapro and Zoloft—as well as other antidepressant medications—could lead to weight gain. While head-to-head comparisons for Zoloft vs Lexapro are not available, studies suggest that both can cause weight gain when taken long-term.
Bupropion was associated with the least amount of weight gain, close to none. Two others that also appeared to have less weight gain were amitriptyline and nortriptyline. Amitriptyline and nortriptyline are older drugs. Because newer drugs tend to have fewer side effects, those two aren't prescribed as frequently.
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Shorter-term treatment in adults usually does not lead to substantial weight gain, but most patients need to take Zoloft for an extended period of time. In children, weight loss has been reported with Zoloft possibly due to side effects like nausea or loss of appetite.
Sertraline can make you feel more or less hungry than usual, so you may gain or lose weight when you start taking it. If you start to have problems with your weight while taking sertraline, talk to your doctor or pharmacist.
A person taking Lexapro may experience some weight gain, especially with long-term use. That risk may continue for up to six years. 3 There are many reasons why this may occur. One of Lexapro's weight gain mechanisms is that it increases serotonin levels, and serotonin plays a role in weight control.