Sarolaner, one of the ingredients in SIMPARICA TRIO, is a member of the isoxazoline class. This class has been associated with neurologic adverse reactions including tremors, ataxia, and seizures. Seizures have been reported in dogs receiving isoxazoline class drugs, even in dogs without a history of seizures.
Side Effects & Warnings
Simparica may cause abnormal neurologic signs such as tremors, unsteadiness, and/or seizures. Simparica has not been evaluated in dogs that are pregnant, breeding or lactating. Simparica has been safely used in dogs treated with commonly prescribed vaccines, parasiticides and other medications.
What Are Potential Simparica Trio Side Effects in Dogs? Side effects are uncommon, but may occur in some cases. In clinical trials, vomiting and diarrhea were the most frequently reported adverse reactions.
If you give your dog or cat the flea and tick preventatives Bravecto, Nexgard, Simparica, or Credelio, the FDA wants you to be aware that these medications may cause neurological issues like stumbling, seizures, and twitching in your pet.
I have read that Simparica may cause side effects including muscle tremors, diarrhea, lethargy, anorexia, otitis externa, hyperactivity, neurological side effects, seizures, convulsions, anxiety and skin irritation.
The cumulative deaths reported to April 2021 ranged from a high of 2,627 (24%) for fluralaner (Bravecto®) to 726 (2.8%) for afoxolaner (NexGard®) and 412 (12.7%) for sarolaner (Simparica®).
That same information showed 720 reported seizures for Bravecto in four years and 557 for Simparica in three years. For Credelio, six seizures were reported in the first six months after its approval.
The police dog in question who was given Simparica Trio eventually recovered. It is important to help the animal detox, giving a twice-daily dose of 250-500 mg milk thistle for three to four weeks, plus a few drops of fish oil and a teaspoon of coconut oil daily.
The most common reason is that the fleas are being killed and the dog is no longer being bitten by them. This can cause the dog to feel itchy and uncomfortable, which may lead to restlessness. Additionally, the chemicals in some flea treatments can be irritating to dogs, leading to discomfort and restlessness.
The most common signs of toxicity from pyrethrum-based flea products are muscle tremors and excessive salivation. Common signs of toxicity from flea products containing organophosphates are diarrhea, vomiting, difficulty breathing, small pupils, muscle tremor, weakness or falling over, and drooling.
Both products are safe for dogs when following directions and have been approved by the FDA to treat and prevent flea and tick infestations. While Simparica was trialed and not approved, Nexgard has not yet been evaluated for use in breeding, pregnant, or lactating dogs.
Monthly Simparica protects dogs from ticks and fleas for 35 days. Have you ever been a few days late giving your dog monthly tick and flea protection?
Simparica. The top three adverse events that have been observed in pets taking Simparica are vomiting, diarrhea and lethargy and the occurrence of these side effects are 1 in 10,000.
Vomiting, lethargy and diarrhea are the most common side effects reported.
Dogs that have ataxia may fall, have difficulty walking, walk in circles, or tilt their heads. You may notice that your dog's eyes flutter side to side or up and down. Vestibular ataxia can make your dog feel dizzy and nauseated and may cause vomiting.
NexGard Chew is also effective in killing adult fleas, so it can help reduce the risk of your dog getting flea bite dermatitis. If you're looking for a safe and effective flea and tick treatment for your dog, NexGard Chew is the way to go.
Symptoms of Pyrethrin and Pyrethroid Toxicity in Dogs
Most of the time, flea and tick medicine poisoning occurs due to the ingestion (whether accidentally or intentionally) of the medicine, as opposed to the application. However, poisoning can occur due to application only.
Out of the ordinary, restless behavior in your dog may indicate some levels of pain, health issues, or anxiety. Most people can determine if the nature of the problem is behavioral or medical. Dogs sometimes develop overly attached bonds to their people, and when you leave your dog, he may become restless.
Pyrethroid-based topical flea and tick preventives, especially “spot-on” formulas, cause symptoms that can develop from 15 minutes to several hours after application to your dog's skin. Clinical signs include: A tingling sensation; dogs will excessively itch or scratch that spot on their skin.
Adverse reactions in dogs treated with SIMPARICA TRIO included diarrhea. In a third field safety and effectiveness study, SIMPARICA TRIO was administered to 120 dogs with roundworms. Adverse reactions in dogs treated with SIMPARICA TRIO included diarrhea and vomiting.
Cedar oil is a good replacement for flea medications for dogs like Bravecto Chews for Dogs, Frontline Plus for Dogs, Revolution for Dogs, Simparica for Dogs, Advantage Multi for Dogs, and more.
For flea or tick infestations, one treatment with Simparica Trio is effective for up to 5 weeks. Further flea or tick treatment should be continued using a different veterinary medicine with a narrower range of action.
Simparica may cause neurologic signs such as tremors, unsteadiness and/or seizures in dogs with or without a history of neurologic disorders. Simparica has not been evaluated in pregnant, breeding or lactating dogs. The most common adverse reactions in clinical trials were vomiting and diarrhea.
Isoxazoline products have been associated with neurologic adverse reactions, including muscle tremors, ataxia, and seizures in some dogs and cats. Although most dogs and cats haven't had neurologic adverse reactions, seizures may occur in animals without a prior history.
Use with caution in dogs with a history of seizures. Simparica Trio contains sarolaner, a member of the isoxazoline class, which has been associated with neurologic adverse reactions including tremors, ataxia, and seizures in dogs with or without a history of neurologic disorders.